Preparation and <i>in-vitro</i>/<i>in-vivo</i> evaluation of curcumin nanosuspension with solubility enhancement

Li, Xin; Yuan, Huiling; Zhang, Caiyun; Chen, Weidong; Cheng, Weiye; Chen, Xin; Yang, Xi

doi:10.1111/jphp.12575

Cited by 40 publications

(15 citation statements)

References 40 publications

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“…High cumulative release concentration is obviously essential in increasing the bioavailability of Curcumin. The release behavior may be induced by improved solubility of Curcumin in water, consistent with the findings of Li [24] and Kumar [25]. …”

Section: Discussionsupporting

confidence: 87%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

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Renal ischemia-reperfusion injury (IRI) is a major complication in clinical practice. However, despite its frequency, effective preventive/treatment strategies for this condition are scarce. Curcumin possesses antioxidant properties and is a promising potential protective agent against renal IRI, but its poor water solubility restricts its application. In this study, we constructed curcumin-carrying distearoylphosphatidylethanolamine-polyethylene glycol nanoparticles (Cur-NPs), and their effect on HK-2 cells exposed to IRI was examined in vitro. Curcumin encapsulated in NPs demonstrated improved water solubility and slowed release. Compared with the IRI and Curcumin groups, Cur-NP groups displayed significantly improved cell viability, downregulated protein expression levels of caspase-3 and Bax, upregulated expression of Bcl-2 protein, increased antioxidant superoxide dismutase level, and reduced apoptotic rate, reactive oxygen species level, and malondialdehyde content. Results clearly showed that Cur-NPs demonstrated good water solubility and slow release, as well as exerted protective effects against oxidative stress in cultured HK-2 cells exposed to IRI.

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Section: Discussionsupporting

confidence: 87%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

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“…However, there was no exothermic peak appeared in the thermogram of GNA‐ZN‐NPs, meaning that GNA might transform to an amorphous form after the preparation of nanoparticles. The reason may be that GNA could not rapidly combine into the developing crystal lattice within a limited time in the presence of stabilizers . The degree of the amorphization in GNA‐ZN‐NPs was significantly higher than GNA, which resulted in the reduced crystallinity and the increased solubility.…”

Section: Resultsmentioning

confidence: 99%

“…The reason may be that GNA could not rapidly combine into the developing crystal lattice within a limited time in the presence of stabilizers. [36] The degree of the amorphization in GNA-ZN-NPs was significantly higher than GNA, which resulted in the reduced crystallinity and the increased solubility.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

Cheng

Wang

Zhang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Gambogenic acid (GNA), one of the main active ingredients isolated from Garcinia cambogia, has shown diverse antitumour activities. However, short biological half‐life and low oral bioavailability severely limit its clinical application. Here, we developed GNA‐loaded zein nanoparticles (GNA‐ZN‐NPs) based on phospholipid complex and zein nanoparticles to prolong the circulation time and enhance oral bioavailability of GNA. Methods The physicochemical properties of GNA‐ZN‐NP were characterized in details. The in vitro release profile, in vivo pharmacokinetic experiments and tissue distribution of GNA‐ZN‐NPs were also evaluated. Key findings The particle size, PDI and encapsulation efficiency of GNA‐ZN‐NPs were 102.90 nm, 0.027 and 76.35 ± 0.64%, respectively. The results of SEM, FTIR, DSC and XRD demonstrated that GNA‐ZN‐NPs were prepared successfully. The in vitro dissolution of GNA‐ZN‐NPs exhibited controlled release compared with raw GNA solution. The pharmacokinetic study showed that the AUC of GNA‐ZN‐NPs was significantly increased, and the t1/2 and MRT values of GNA‐ZN‐NPs were 3.21‐fold and 2.19‐fold higher than that of GNA solution. Tissue distribution results illustrated that GNA‐ZN‐NPs showed hepatic‐targeting properties. Conclusion GNA‐ZN‐NPs significantly enhanced the oral bioavailability and prolonged half‐life of GNA, providing a promising oral drug delivery system to improve in vivo pharmacokinetic behaviour of GNA.

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“…Curcumin nanosuspension was prepared with solvents of PVPK30 and SDS and curcumin released 84% within 34 h and it showed higher toxicity as well. Pharmacokinetic studies showed that CU-NS quickly reached the tissue organs, suggesting that the formulation is effective; however, toxicity of SDS remains questionable when translated [65]. No other study showed about the toxicity of curcumin or its derivative molecules with or without other compounds and hence further studies is needed to confirm the previous findings.…”

Section: Toxicity Study Of Curcumin Nanocomplexmentioning

confidence: 94%

Augmentation of therapeutic potential of curcumin using nanotechnology: current perspectives

Sivasami

Hemalatha

2018

Artificial Cells, Nanomedicine, and Biotechnology

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Curcumin, an active principle of Curcuma longa, is extracted from the rhizome. Its therapeutic efficiency has been proved using various in vitro and in vivo models. Inflammatory, neoplastic and preneoplastic diseases are the major targets using curcumin as therapeutic agent. Feasible clinical formulations could not be obtained because of its lack of solubility, stability and higher degradation rate. Recently, many techniques have been evolved to improve the physicochemical properties of pharmacological compounds, thereby increasing their biological activity. Curcumin has been developed using various techniques, particularly micro and nanotechnology to improve its stability and bioavailability. This review focuses on the studies pertaining to the delivery of curcumin in the form of micro and nanosize formulations for the treatment of a variety of diseases.

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Preparation and in-vitro/in-vivo evaluation of curcumin nanosuspension with solubility enhancement

Abstract: The Cur-NS significantly increased the water solubility and half-time of Cur, suggesting its potential as a nanocarrier in the delivery of Cur for future clinical application.

Cited by 40 publications

References 40 publications

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

Augmentation of therapeutic potential of curcumin using nanotechnology: current perspectives

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