Preparation and in vitro evaluation of plasma-sprayed bioactive akermanite coatings

Abstract

Bioactive ceramic coatings on titanium (Ti) alloys play an important role in orthopedic applications. In this study, akermanite (Ca(2)MgSi(2)O(7)) bioactive coatings are prepared through a plasma spraying technique. The bonding strength between the coatings and Ti-6Al-4V substrates is around 38.7-42.2 MPa, which is higher than that of plasma sprayed hydroxyapatite (HA) coatings reported previously. The prepared akermanite coatings reveal a distinct apatite-mineralization ability in simulated body fluid. Furthermore, akermanite coatings support the attachment and proliferation of rabbit bone marrow mesenchymal stem cells (BMSCs). The proliferation rate of BMSCs on akermanite coatings is obviously higher than that on HA coatings.

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

“…This was more than twice the bonding strength of HA coatings (23.5 MPa)-a material that is already is in clinical use-and stronger than other reported silicate-based bioceramic coatings, such as akermanite coating (42.2 MPa), [24] forsterite coating (41.5 MPa) [46], diopside coating (32.5 MPa) [47] and sphene coating (33.2 MPa) [15]. We believe there are two major factors contributing to the CLT coatings' greatly improved bonding strength.…”

“…Silicate-based ceramics has a thermal expansion coefficient similar to Ti-6Al-4V [24,25] and offers some clues as to the high bonding strength CLT coatings have with Ti-6Al-4V. Magnesium (Mg) plays an essential role in bone metabolism and its depletion can adversely affect all stages of skeletal metabolism, resulting in retardation of bone growth and abnormal osteoblastic and osteoclastic cells behaviors [26,27].…”

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

“…Along with calcium silicate, a range of DCSCs have been coated onto titanium alloys and exhibited significant increases in bonding strength compared to hydroxyapatite coatings. The bonding strength of DCSC coatings to the titanium substrate was generally within the range of 25–45 MPa, including akermanite (42.2 MPa) [143], diopside (32.5 MPa) [144], sphene (33.2 MPa) [145], baghdadite (28 MPa) [146], hardystonite (~26 MPa) [141], and Sr-hardystonite (~35 MPa) [141]. In comparison, calcium silicate coatings on titanium showed bonding strength of 24–43 MPa [147,148], while hydroxyapatite coatings were within the range of 10–20 MPa [146,149].…”

Functional Polyethylene Terephthalate with Nanometer‐Sized Bioactive Glass Coatings Stimulating In Vitro and In Vivo Osseointegration for Anterior Cruciate Ligament Reconstruction

“…Akermanite (AKT), as a Ca‐, Mg‐ and Si‐containing bioceramic, has recently received significant attention for bone regeneration application due to its excellent osteostimulation property . Our previous studies showed that AKT bioceramics significantly stimulated the osteogenic differentiation of BMSCs and human periodontal ligament cells (hPDLCs) as compared to β‐TCP bioceramics .…”