Preparation and <i>in Vitro</i> Antitumor Study of Two-Dimensional Muscovite Nanosheets

Xia, Tian; Lei, Can; Xu, Chi; Peng, Na; Li, You; Yang, Xiaoyan; Cheng, Zhengzai; Gauthier, Mario; Gu, Huazhi; Zou, Tao

doi:10.1021/acs.langmuir.0c02393

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…The biosafety of the graft material is a relevant issue (Rohaizad et al, 2020). After being transplanted into the body, the material degrades, enters the circulatory system, and is metabolized in various tissues, a process that may produce toxic effects (Xia et al, 2020). In the present study, we collected blood and serum from rats to evaluate the toxicological characteristics of Mg-HA.…”

Section: Discussionmentioning

confidence: 98%

Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16

Hua

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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The hydroxyapatite (HA) coating on carbon/carbon (C/C) is reasonable and feasible to obtain bone graft materials with appropriate mechanical and biological properties. However, improvement of the physical and chemical properties of HA-C/C composites to promote bone regeneration and healing remains a challenge. In our present study, the HA coatings on C/C with magnesium (Mg) (Mg-HA-C/C) composites were synthesized that Ca (NO3)2, Mg (NO3)2, and NH4H2PO4 were mixed and coatings were made by electromagnetic induction deposition’s heating. As determined with in vitro experiments, Mg-HA-C/C composites containing 10 and 20% Mg decreased miR-16 levels, increased cell viability, elevated the levels of osteogenesis-related genes, and promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) seeded on their surfaces. In a rat model of skull defects, compared to the control group, at 4 and 12 weeks after the operation, the bone volume fraction (BV/TV) of Mg-HA-C/C composite group was increased by 8.439 ± 2.681% and 23.837 ± 7.845%, as well as the trabecular thickness (Tb.Th) was 56.247 ± 24.238 μm and 114.911 ± 34.015 μm more. These composites also increased the levels of ALP and RUNX2 in skull. The Mg-HA-C/C composite-enhanced bone regeneration and healing were blocked by in situ injection of an miR-16 mimic lentivirus vector. Thus, Mg-HA-C/C composites promote osteogenic differentiation and repair bone defects through inhibiting miR-16.

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Section: Discussionmentioning

confidence: 98%

Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16

Hua

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…This notion has been veried adequately, as exfoliation, intercalation and ion-exchange mainly occurring in this direction. [13][14][15][16][17][18][19][20][21][22][23][24][25][26] These descriptions probably explain the observed discrepancy. Normally, discrepancy can be amplied by factor elevation; thus, the ratio seems to increase greatly.…”

Section: Lattice Stability Analysismentioning

confidence: 92%

Remarkable damage in talc caused by electron beam irradiation with a dose of up to 1000 kGy: lattice shrinkage in the Z- and Y-axis and corresponding intrinsic microstructural transformation process speculation

Huang

et al. 2021

RSC Adv.

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“…[92] Moreover, white mica sheets were prepared by polyamine intercalation method, and mainly promoted immunostimulatory M1 polarization of RAW 264.7 macrophages, providing the basis for chemo-combined immune cancer therapy. [93]…”

Section: Other 2d Materialsmentioning

confidence: 99%

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Bianco

2021

Small

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metal carbides or nitrides. [3][4][5][6][7][8] Based on their different properties, such 2D materials could be used as efficient means for drug delivery, photothermal therapy (PTT, which utilizes photothermal agents to convert light energy into hyperthermia, leading to the thermal ablation of cancer cells), photodynamic therapy (PDT, which uses photosensitizers to transfer photon energy into reactive oxygen species, provoking cancer cell death), chemodynamic therapy (CDT, which is based on Fenton or Fenton-like reactions to convert H 2 O 2 into hydroxyl radicals triggering apoptosis and inhibiting tumor growth), radiotherapy (RT, which uses high-dose radiation to kill cancer cells and eliminate tumors), radiodynamic therapy (RDT, which utilizes ionizing radiation to excite photosensitizers to generate 1 O 2 against cancer), and specific combination thereof. [8][9][10] In the years, cancer immunotherapy gets exceptional growing progress, especially after ipilimumab obtained the approval from FDA. [11] Ipilimumab is a monoclonal antibody directed towards cytotoxic T-lymphocyte-associated protein 4 (CTLA4) showing a significant increase in the survival of patients with metastatic melanoma. It is well known that cancer immunotherapy is based on immune system activation to target and eradicate cancer cells with durable antitumor responses and less metastasis and recurrence than other therapeutic strategies. [12,13] Immune biochemical factors, vaccines, checkpoint inhibitors, monoclonal antibodies, and other molecules have been widely utilized as efficient modulators to activate the immune system. Checkpoint blockade immunotherapy is a recently developed strategy based on the use of checkpoint inhibitors to arrest the immunosuppressive pathways promoting antitumor T cell activation and maintaining the antitumor T cell effector function. [14,15] However, the cancer immunotherapy efficiency is still not satisfactory. Indeed, the overall patient response rates are usually below 40% by checkpoint inhibitor therapy. [16] Meanwhile, immunotherapy can trigger mild to serious side effects, such as nausea, vomiting, lung/skin/gastrointestinal/renal toxicities, hypothyroidism, arthralgia, vasculitis, autoimmune hepatitis, and other dysfunctions. [17,18] To reduce or to overcome the side effects caused by immunotherapy, and further enhance its efficiency, 2D materials provide incomparable advantages, including high specific surface area, biocompatibility, chemical surface modification, targeting possibility, tumor accumulation, and unique physicochemical In the last years, cancer immunotherapy has started to attract a lot of attention, becoming one of the alternatives in the clinical treatment of cancer. Indeed, one of the advantages of immunotherapy is that both primary and distant tumors can be efficiently eradicated through a triggered immune response. Due to their large specific surface area and unique physicochemical properties, 2D materials have become popular in cancer immunotherapy, especially as efficient drug carriers. ...

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Preparation and in Vitro Antitumor Study of Two-Dimensional Muscovite Nanosheets

Cited by 10 publications

References 35 publications

Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16

Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16

Remarkable damage in talc caused by electron beam irradiation with a dose of up to 1000 kGy: lattice shrinkage in the Z- and Y-axis and corresponding intrinsic microstructural transformation process speculation

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

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