Preparation and evaluation of microporous organogel scaffolds for cell viability and proliferation

Lukyanova, Lyubov; Franceschi‐Messant, Sophie; Vicendo, Patricia; Pérez, Emile; Rico‐Lattes, Isabelle; Weinkamer, Richard

doi:10.1016/j.colsurfb.2010.03.044

Cited by 20 publications

(9 citation statements)

References 60 publications

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“…[11] These organogelators form fibers, strands, tapes or helix via unidimensional growth of the molecules. [2,8,11] Liquid paraffin [23] Sorbitan tristearate + Lecithin Sunflower oil [24] Phytosterol + Oryzaznol Various edible oils [25] TAG, DAG, MAG, FA, Waxes Various edible oils [25] 12-Hydroxystearic acid (12-HAS) Soyabean oil or capric/ caprylic triglyceride [26] ß-Cyclodextrin (ß-CD) Para substituted anilines (ps-An) Lithium chloride in N, N-dimethyl formamide [27] Triazine functionalized with a-amino acidic appendages Haloalkanes, and aromatic solvents [28] Figure 2: Method of formation of organogels by fluid-filled fiber mechanism [8,31] Figure 3: Method of formation of organogels by solid fiber mechanism [8,31] In case of cinnamic acid salt gelators it has been investigated that, prerequisite for the one-dimensional (1D) growth of the gel fibrils is mainly governed by the 1D hydrogen-bonded networks involving the ion pair. Whereas all the non-gelators show either two-(2D) or zero-dimensional (0D) hydrogen bonded assemblies involving the ion pair.…”

Section: Mechanism Of Gel Formationmentioning

confidence: 99%

Oleogel: A promising base for transdermal formulations

Balasubramanian¹,

Damodar²,

Sughir³

2012

Asian J Pharm

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S ince last two decades the work on oleogels is being exploited in pharmaceutical, cosmetics, and nutraceutical industries for their desired rheological, physical, and chemical stabilities in semisolid formulations. Recently, we had developed a stable and efficacious oleogel containing diclofenac diethylamine for topical application. The present review article deals with the literature of oleogels including its application in various fields from last few decades till date. The literature reveals that the oleogels have simplicity in manufacturing, high physical, chemical, and mechanical stability and better invivo efficacy, which make them appropriate to employ as bases for topical formulations.

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Section: Mechanism Of Gel Formationmentioning

confidence: 99%

Oleogel: A promising base for transdermal formulations

Balasubramanian¹,

Damodar²,

Sughir³

2012

Asian J Pharm

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“…Such gels are normally obtained by directly dissolving the gelator in oil at high temperature, followed by cooling of the solution to a temperature below the gelation transition temperature (T gel ). At T gel , the oil flow is no longer observed over long periods [10,11]. Ogg are interesting drug delivery systems for different administration routes [12,13], and their potential as hydrophobic reservoirs has been demonstrated [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Gelled oil particles: A new approach to encapsulate a hydrophobic metallophthalocyanine

Siqueira-Moura

Franceschi‐Messant

Blanzat

et al. 2013

Journal of Colloid and Interface Science

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Chloroaluminum phthalocyanine (ClAlPc) is a promising sensitizer molecule for photodynamic therapy, but its hydrophobicity makes it difficult to formulate. In this study, we have efficiently encapsulated ClAlPc into gelled soybean oil particles dispersed in water. 12-Hydroxystearic acid (HSA) and polyethyleneimine (PEI) were the gelling and stabilizing agents, respectively. The preparation process involved hot emulsification above the gelation temperature (Tgel), followed by cooling to room temperature, which gave a colloidal dispersion of gelled particles of oil in aqueous medium. The gelled particles containing ClAlPc had a medium diameter of 280 nm, homogeneous size distribution (polydispersity index ≈0.3) and large positive zeta potential (about +50 mV) and showed a spherical morphology. The gelled oil particle formulations exhibited good physical stability over a 6-month period. ClAlPc interfered with the HSA self-assembly only slightly, and decreased the gelation temperature to a small extent; however it did not affect gelation process of the oil droplets. The amounts of PEI and HSA employed during the preparation allowed us to control particle size and the dispersion stability, a phenomenon that results from complex electrostatic interactions between the positively charged PEI and the negatively charged HSA fibers present on the gelled particles surface. In summary, by using the right ClAlPc, HSA, and PEI proportions, we prepared very stable dispersions of gelled soybean oil particles with excellent ClAlPc encapsulation efficiency. The obtained colloidal formulation of gelled oil particles loaded with ClAlPc shall be very useful for photodynamic therapy protocols.

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“…Lukyanova et al explored cell proliferation in 12‐hydroxystearic acid structured soybean oil or caprylic/capric triglyceride oleogels . While dynamic moduli versus amplitude or frequency were not reported, the cytocompatibility of these systems was found to be excellent.…”

Section: Macromolecule‐ and Drug‐structured Oleogelsmentioning

confidence: 99%

Gels without Vapor Pressure: Soft, Nonaqueous, and Solvent‐Free Supramolecular Biomaterials for Prospective Parenteral Drug Delivery Applications

Tabet

Wang

2018

Adv Healthcare Materials

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now making up 90% of the drugs in development. [9] Since hydrogel matrices are predominantly hydrophilic with high water content, there may be limits in loading clinically relevant concentrations of poorly water-soluble APIs and achieving bolus-free, prolonged, zero or first-order release kinetics of these drugs over several weeks. [11] Further challenges include the mechanical fragility of many biodegradable hydrogels, dehydration over time, and nonideal drug release due to leakage or phase separation. [12] Although mechanical weaknesses of hydrogels may be overcome by several approaches such as introducing a second interpenetrating supramolecular or covalent network within the primary hydrogel matrix, [13] other problems due to the inherent presence of water have no straightforward remedy.Given these current limitations in hydrogel technology, in particular those associated with the incompatibility of aqueous matrices with controlled release of poorly soluble drugs, some groups have explored whether nonaqueous matrices can overcome these challenges. [14,15] One alternative class of materials to hydrogels is organogels. A typical organogel is composed of a hydrophobic or amphiphilic gelator and an organic solvent, such as N-methyl-2-pyrrolidone (NMP) or dimethyl sulfoxide (DMSO). [3] A common strategy for the use of organogels in parenteral drug delivery is direct injection of polymer mixed with drug and added organic solvent for solubilization and viscosity reduction. Subsequent solvent leeching results in the formation of an implant in situ to release the drug over time. [14] However, compelling reasons against the clinical adoption of such materials exist, including the concern over safety of injecting organic-solvent loaded materials into patients with potentially harmful or unknown biological consequences. [3,16] A highly promising subset of organogels that has seen limited adoption into drug delivery is called oleogels, which do not contain organic solvents, such as NMP, and consist of oligomers or polymer oils/melts. [8] These materials are supramolecular analogues to soft, covalent elastomers. A key advantage of such polymer melt-based gels is their lack of any appreciable vapor pressure. [17] Such stability and lack of evaporation over time makes these materials quite distinct from hydrogels or organic solvent-based organogels. Whereas hydrogels can be left sealed on the benchtop or in the fridge and remain unaltered due to evaporation on the order of days, solvent-free gels are potentially stable for months to years. While the application of these The engineering advantages of soft, nonaqueous, solvent-free supramolecular materials have resulted in their emerging transition and adoption from a predominantly food, cosmetics, and paint industry-driven technology to biocompatible matrices for parenteral drug delivery. Factors that have contributed to this trend are the drastic increase of hydrophobic and combination drugs in the pharmaceutical pipeline and the limitations of hydrated drug delivery materia...

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Preparation and evaluation of microporous organogel scaffolds for cell viability and proliferation

Cited by 20 publications

References 60 publications

Oleogel: A promising base for transdermal formulations

Oleogel: A promising base for transdermal formulations

Gelled oil particles: A new approach to encapsulate a hydrophobic metallophthalocyanine

Gels without Vapor Pressure: Soft, Nonaqueous, and Solvent‐Free Supramolecular Biomaterials for Prospective Parenteral Drug Delivery Applications

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