Preparation and evaluation of microparticles from thiolated polymers via air jet milling

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

“…33 Future studies could eliminate this confounder by using a standardized size reduction method, such as jet milling, to produce powders of narrow size distributions. 34 The excipients in the Tegretol 200 tablet could potentially play a role in its drug release profile. Microcrystalline cellulose swells in contact with water through the capillary action of water into the pores, which can force the drug out of the scaffold through the holes.…”

Preparation and graft copolymerisation of thiolated β-chitin and chitosan derivatives

“…Thiolated chitosan polymers have been investigated for their metal binding capacity and selectivity (Cárdenas, Orlando, & Edelio, 2001;Lasko, Pesic, & Oliver, 1993), as macroinitiators for graft copolymerisation (Kurita, Hashimoto, Ishii, & Mori, 1996;Kurita, Hashimoto, Yoshino, Ishii, & Nishimura, 1996;Kurita, Inoue, & Harata, 2002) and for drug delivery and wound healing (Bernkop-Schnürch, Hornof, & Guggi, 2004;Guggi, Langoth, Hoffer, Wirth, & Bernkop-Schnürch, 2004;Hornof, Kast, & Bernkop-Schnürch, 2003;Hoyer, Schlocker, Krum, & Bernkop-Schnürch, 2008;Krauland, Guggi, & Bernkop-Schnürch, 2006;Masuko et al, 2005;Matsuda, Kobayashi, Itoh, Kataoka, & Tanaka, 2005;Werle & BernkopSchnürch, 2008). The thiol functional groups (R-SH) in the polymer can enhance the mucoadhesive properties of chitosan by forming disulfide bonds (RASASAR 0 ) with cysteine residues in proteins .…”

Physico-mechanical and Stability Evaluation of Carbamazepine Cocrystal with Nicotinamide

“…Techniques for physical and chemical alteration for enhanced drug dissolution profiles include complexation of poorly soluble drugs with β-cyclodextrans (8), jet milling to create microparticles (9), high-pressure homogenization to form nanoparticles (10), co-precipitation (11), and co-crystallization (12). Cocrystals are a multicomponent system in which two or more components crystallize into the same crystal lattice with distinctive physicochemical properties from the individual parent compounds.…”