Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim, Seng Han; Chia, Samuel Ming Yuan; Kang, Lifeng; Yap, Kevin Yi-Lwern

doi:10.1016/j.xphs.2016.04.031

Cited by 46 publications

(17 citation statements)

References 43 publications

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“…15,16 The first limitation has been the lack of suitable polymers for successful development of FDM 3D printed tablets. Some of the polymers that have been tested as carriers or matrices for drugs in 3D printing are poly(lactic acid), [17][18][19][20] poly(vinyl alcohol), 2,7,[21][22][23] polyvinylpyrrolidone, 24 methacrylate, 5 hydroxypropyl cellulose, 5 hydroxypropyl methylcellulose acetate succinate (HPMCAS), 25 mixtures of polymers, 26 acrylonitrile butadiene styrene, 27 poly(ε-caprolactone), 28 ethyl cellulose, 29 and ethylvinyl acetate. 30 Filaments with optimum mechanical properties, flexibility, and melt viscosity to pass through the printer nozzle and thermal stability are required for successful 3D printing.…”

Section: Introductionmentioning

confidence: 99%

“…As a consequence, such tablets appear to be more suitable for modified release rather than immediate release of drugs. 27,34 However, the majority of the oral dosage forms currently available in the market are immediate release tablets, and, in particular, immediate release dosage forms are necessary for drugs requiring rapid onset of action after oral administration. 40 There are a few reports on FDM 3D printing where the fabrication of immediate release tablets has been explored.…”

Section: Introductionmentioning

confidence: 99%

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Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability

Solanki

Tahsin

Shah

et al. 2018

Journal of Pharmaceutical Sciences

235

117

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The primary aim of this study was to identify pharmaceutically acceptable amorphous polymers for producing 3D printed tablets of a model drug, haloperidol, for rapid release by fused deposition modeling. Filaments for 3D printing were prepared by hot melt extrusion at 150°C with 10% and 20% w/w of haloperidol using Kollidon VA64, Kollicoat IR, Affinsiol15 cP, and HPMCAS either individually or as binary blends (Kollidon VA64 + Affinisol 15 cP, 1:1; Kollidon VA64 + HPMCAS, 1:1). Dissolution of crushed extrudates was studied at pH 2 and 6.8, and formulations demonstrating rapid dissolution rates were then analyzed for drug-polymer, polymer-polymer and drug-polymer-polymer miscibility by film casting. Polymer-polymer (1:1) and drug-polymer-polymer (1:5:5 and 2:5:5) mixtures were found to be miscible. Tablets with 100% and 60% infill were printed using MakerBot printer at 210°C, and dissolution tests of tablets were conducted at pH 2 and 6.8. Extruded filaments of Kollidon VA64-Affinisol 15 cP mixtures were flexible and had optimum mechanical strength for 3D printing. Tablets containing 10% drug with 60% and 100% infill showed complete drug release at pH 2 in 45 and 120 min, respectively. Relatively high dissolution rates were also observed at pH 6.8. The 1:1-mixture of Kollidon VA64 and Affinisol15 cP was thus identified as a suitable polymer system for 3D printing and rapid drug release.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability

Solanki

Tahsin

Shah

et al. 2018

Journal of Pharmaceutical Sciences

235

117

View full text Add to dashboard Cite

show abstract

“…The components that can be extruded are molten polymers, suspensions, semisolids, pastes. 23,24 Zip dose Zip dose is the world's initial and only FDA-approved, commercial-scale 3DP in current therapeutic areas for pharmaceutical manufacturing areas. It has a distinctive digitally coded layering and zero compression practices, used for tablet formulation with large dosage and prompt disintegration.…”

Section: Extrusion 3d Printingmentioning

confidence: 99%

3D Printing in Pharmaceutical Technology – A Review

Ponni

Swamivelmanickam

Sivakrishnan

2020

IJPI

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Three-dimensional printing is a revolutionary technique that uses computer aided design software and programming to create three dimensional objects by placing material on a substrate. 3D printing is an additive layer manufacturing techniques, where consecutive layers of material are deposited or solidified to form a 3D structure. Medicinal substances is configured in three dimensional with computer assisted design module and transformed to a machine legible form which suggests the exterior emerge of the 3D dose form, then it sliced this surface into number of different printable coats and convey these layers to the machine. The different 3D printing techniques has been developing and developed to fabricate novel solid dosage forms, which are among the most well-known and discrete products today. The 3D printing process desires to be espoused by pharmaceutical sector and capable of exploring the marvels fetched by the approach. 3D printing can include a very new possibilities to optimized medicine. The current review is an effort of briefing various methods

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“…Moreover, 3D printing was employed to fabricate cylindrical-shaped ABS containers, having two holes placed in different positions, to be filled with a drug formulation. By these systems, zero-order release kinetics would be attained avoiding the typical initial burst effect 28 .…”

Section: D Printing Of Drug Productsmentioning

confidence: 99%

Three-Dimensional Printing of Medicinal Products and the Challenge of Personalized Therapy

Zema

Melocchi

Maroni

et al. 2017

Journal of Pharmaceutical Sciences

142

107

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By 3-dimensional (3D) printing, solid objects of any shape are fabricated through layer-by-layer addition of materials based on a digital model. At present, such a technique is broadly exploited in many industrial fields because of major advantages in terms of reduced times and costs of development and production. In the biomedical and pharmaceutical domains, the interest in 3D printing is growing in step with the needs of personalized medicine. Printed scaffolds and prostheses have partly replaced medical devices produced by more established techniques, and more recently, 3D printing has been proposed for the manufacturing of drug products. Notably, the availability of patient-tailored pharmaceuticals would be of utmost importance for children, elderly subjects, poor and high metabolizers, and individuals undergoing multiple drug treatments. 3D printing encompasses a range of differing techniques, each involving advantages and open issues. Particularly, solidification of powder, extrusion, and stereolithography have been applied to the manufacturing of drug products. The main challenge to their exploitation for personalized pharmacologic therapy is likely to be related to the regulatory issues involved and to implementation of production models that may allow to efficiently turn the therapeutic needs of individual patients into small batches of appropriate drug products meeting preset quality requirements.

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Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Cited by 46 publications

References 43 publications

Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability

Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability

3D Printing in Pharmaceutical Technology – A Review

Three-Dimensional Printing of Medicinal Products and the Challenge of Personalized Therapy

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