Preparation and Evaluation of Glibenclamide-Loaded Biodegradable Nanoparticles

Behera, Amulyaratna; Sahoo, Sabuj

doi:10.4314/tjpr.v11i3.2

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…These outcomes may be attributed to the lower proportion of the polymer with increasing the drug polymer ratio resulted in augmented drug diffusion to the dissolution medium [ 37 ]. These results are in full concordance with those obtained by Behera et al [ 38 ], who prepared glibenclamide NPs and found that the release rate increases by increasing the drug polymer ratio.…”

Section: Discussionsupporting

confidence: 92%

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

et al. 2020

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Objectives: The aim of this study was to prepare doxycycline polymeric nanoparticles (DOXY-PNPs) with hope to enhance its chemotherapeutic potential against solid Ehrlich carcinoma (SEC). Methods: Three DOXY-PNPs were formulated by nanoprecipitation method using hydroxypropyl methyl cellulose (HPMC) as a polymer. The prepared DOXY-PNPs were evaluated for the encapsulation efficiency (EE%), the drug loading capacity, particle size, zeta potential (ZP) and the in-vitro release for selection of the best formulation. PNP number 3 was selected for further biological testing based on the best pharmaceutical characters. PNP3 (5 and 10 mg/kg) was evaluated for the antitumor potential against SEC grown in female mice by measuring the tumor mass as well as the expression and immunohistochemical staining for the apoptosis markers; caspase 3 and BAX. Results: The biological study documented the greatest reduction in tumor mass in mice treated with PNP3. Importantly, treatment with 5 mg/kg of DOXY-PNPs produced a similar chemotherapeutic effect to that produced by 10 mg/kg of free DOXY. Further, a significant elevation in mRNA expression and immunostaining for caspase 3 and BAX was detected in mice group treated with DOXY-PNPs. Conclusions: The DOXY-PNPs showed greater antitumor potential against SEC grown in mice and greater values for Spearman’s correlation coefficients were detected when correlation with tumor mass or apoptosis markers was examined; this is in comparison to free DOXY. Hence, DOXY-PNPs should be tested in other tumor types to further determine the utility of the current technique in preparing chemotherapeutic agents and enhancing their properties.

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Section: Discussionsupporting

confidence: 92%

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

et al. 2020

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“…The findings of saturation solubility have been assured with the results of GB release, where only up to 35% of GB has been released from PEG 6000 free GB nanoparticles, while the inclusion of PEG 6000 resulted in the release of 99% of GB. No animal study has been conducted in this research work 72 .…”

Section: H-nano-particlesmentioning

confidence: 99%

Strategies Adopted to Improve Bioavailability of Glibenclamide: Insights on Novel Delivery Systems

Nadeem

Abo‐zeid

Sakran

2023

Journal of Advanced Pharmacy Research

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Objectives: Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. According to the statistics declared in 2020 by the World Health Organization [WHO], in the year of 1980, 108 million people have been diagnosed with diabetes mellitus worldwide, then, in 2014, that number had increased to 422 million. In 2020, International Diabetes Federation [IDF] has highlighted that; there will be nearly 700 million adults all over the world to be diagnosed with diabetes by the year of 2045. DM is sub-categorized into Type 1 and Type 2 DM. The former is considered as an autoimmune disorder, in which pancreatic β-cells are destructed, impairing insulin production. While Type 2 DM occurs due to loss of cells sensitivity to insulin. Both are associated with a marked increase in the blood glucose level (BGL) and hence, patients need for pharmacological treatment. T2DM is the most common among diabetic patients and its treatment involves the use of different classes like sulphonylureas, miglitinides and thiazolidinediones. Glibenclamide (GB) belongs to sulphonylureas, its low water solubility accompanied with lower bioavailability demands the use of a higher dose to assure proper management of diabetes. However, this is accompanied in some cases by a severe hypoglycemia that might be lethal in some cases. Therefore, finding a proper delivery system that could improve GB solubility is highly recommended. Nano-medicine could be considered as a promising strategy to improve the solubility and hence, bioavailability of GB. This review is exploring and presenting the recent studies performed to either to encapsulate GB into NPs or reduction of its size to the nano-size level, in order to improve its bioavailability. The review also points to the various obstacles facing nano-medicine clinical application and lack of human studies and sufficient long term safety studies suggesting that future work is needed to make a clearer conclusion about the clinical applicability of the nanodelivery of GB. Methods: This review reports a collection of research articles that investigated the use of several nanodelivery approaches for the delivery of GB up to 2022, using internationally accepted scientific journals and databases. Results: This review shows that the delivery of GB using nano-medicine strategy improves the GB aqueous solubility and hence, improves its oral bioavailability. It also shows that nano-medicine approach could sustain/control the release of GB, therefore, maintaining stable plasma drug concentration and avoiding any undesired fluctuation. Conclusion: The results of the collected articles show that the use of the different nano-medicine categories could be promising to overcome the poor bioavailability of GB. The successful clinical application of the liposomal delivery of certain drugs renders liposomes promising carrier for GB, however, because of the several advantages of the niosomes over liposomes, they seem to be a

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“…-Stable dosage forms of drugs which are either unstable (Alai and Lin, 2015;Bhadra et al, 2016) or have unacceptably low bioavailability in nonnanoparticulate dosage forms (Madgulkar et al, 2016;Ramalingam and Ko, 2016). (2) they control and sustain release of the drug during the transportation and at the site of localization (Behera and Sahoo, 2012), altering organ distribution of the drug and subsequent clearance of the drug so as to achieve increase in drug therapeutic efficacy and reduction in side effects (Kadam et al, 2012).…”

Section: The Advantages Of Using Nanoparticles As Drug Delivery System Includementioning

confidence: 99%

Review article on nanoemulsions and nanostructured lipid carriers

Faheim

Gardouh

Nouh

et al. 2018

Records of Pharmaceutical and Biomedical Sciences

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Lipid nanoparticles, including nanoemulsions (NEs) and nanostructured lipid carriers (NLCs) are colloidal carriers with a lipid matrix that is solid at body temperature. These colloidal carriers have attracted increasing interest for their use in therapeutic and cosmetic applications. The performance of lipid nanoparticle formulations is greatly influenced by their composition and structure. Lipid nanoparticles are generally composed of lipids, surfactants and co-surfactants. The lipid materials used in the production of lipid nanoparticles are usually solid at room temperature. Being well-tolerated in physiological conditions, lipid nanoparticles are typically biocompatible. Liquid lipids, or oils, are specifically used for production of NLCs. In most cases, lipid nanoparticles are produced as dispersions and surface-tailored with surfactants to improve dispersion stability. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery.

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Preparation and Evaluation of Glibenclamide-Loaded Biodegradable Nanoparticles

Abstract: Purpose: To formulate and evaluate glibenclamide (GB)-loaded poly (lactic-co-glycolic)

Cited by 6 publications

References 12 publications

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

Strategies Adopted to Improve Bioavailability of Glibenclamide: Insights on Novel Delivery Systems

Review article on nanoemulsions and nanostructured lipid carriers

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