Preparation and evaluation of a liposomal formulation of sodium cromoglicate

Nagarsenker, Mangal S.; Londhe, Vaishali

doi:10.1016/s0378-5173(02)00583-5

Cited by 41 publications

(24 citation statements)

References 10 publications

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“…Similarly, Nagarsenker and Londhe, [43] Peschka et al, [44] and Vyas et al [41] reported that the inclusion of CHOL in the composition of the lipid bilayer diminished the release rate of drugs from the liposomes.…”

Section: Encapsulation Efficiencymentioning

confidence: 88%

Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

Chorilli

Calixto

Rimério

et al. 2013

Journal of Dispersion Science and Technology

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Liposomes containing hydrogenated soy phosphatidylcholine (PCH), with or without cholesterol (CHOL) and caffeine (CAF), were prepared by sonication and characterized for encapsulation efficiency and mean diameter. Dynamic light scattering assay showed that the incorporation of CHOL decreased significantly the size of the liposomes and led to a more heterogeneous distribution of size raising the CAF encapsulation efficiency. The in vitro drug release studies showed that the encapsulation of the CAF in liposomes produced a reduction in the release rate and the inclusion of CHOL in the liposome formulation delayed still further the release of the CAF.

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Section: Encapsulation Efficiencymentioning

confidence: 88%

Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

Chorilli

Calixto

Rimério

et al. 2013

Journal of Dispersion Science and Technology

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“…The time required for 75% ciprofloxacin release is 6 h in comparison with 2 h for 75% release from 0.3% aqueous solution. This result can explained by the presence of cholesterol in bilayer above the phospholipids, which modulates fluidity by restricting the movement of ciprofloxacin, reducing bilayer permeability, and decreasing the efflux of the encapsulated drug, resulting in prolonged drug retention (38,39). It is also clear that ciprofloxacin release was retarded and more extended by the presence of the carbopol coat, about 10 h required for 75% release of ciprofloxacin.…”

Section: Morphology and Size Analysis Of Liposomesmentioning

confidence: 99%

Ciprofloxacin as Ocular Liposomal Hydrogel

Hosny

2010

AAPS PharmSciTech

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Abstract. The purpose of this study was to prepare and characterize an ocular effective prolonged-release liposomal hydrogel formulation containing ciprofloxacin. Reverse-phase evaporation was used for preparation of liposomes consisting of soybean phosphatidylcholine (PC) and cholesterol (CH). The effect of PC/CH molar ratio on the percentage drug encapsulation was investigated. The effect of additives such as stearylamine (SA) or dicetyl phosphate (DP) as positive and negative charge inducers, respectively, were studied. Morphology, mean size, encapsulation efficiency, and in vitro release of ciprofloxacin from liposomes were evaluated. For hydrogel preparation, Carbopol 940 was applied. In vitro transcorneal permeation through excised albino rabbit cornea was also determined. Optimal encapsulation efficiency of 73.04±3.06% was obtained from liposomes formulated with PC/CH at molar ratio of 5:3 and by increasing CH content above this limit, the encapsulation decreased. Positively charged liposomes showed superior entrapment efficiency (82.01±0.52) over the negatively charged and the neutral liposomes. Hydrogel containing liposomes with lipid content PC, CH, and SA in molar ratio 5:3:1, respectively, showed the best release and transcorneal permeation with the percentage permeation of 30.6%. These results suggest that the degree of encapsulation of ciprofloxacin into liposomes and prolonged in vitro release depend on composition of the vesicles. In addition, the polymer hydrogel used in preparation ensure steady and prolonged transcorneal permeation. In conclusion, ciprofloxacin liposomal hydrogel is a suitable delivery system for improving the ocular bioavailability of ciprofloxacin.

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“…These obtained results can be explained by the ability of cholesterol to modulate the membrane fluidity by restricting the movement of the relative mobile hydraocarbone chains , reducing bilayer permeability 14 and decreasing the efflux of the encapsulated drug, resulting in prolonged drug retention 15 .…”

Section: Table 2 : Particle Size Of Diclofenac Sodium Large Unilamellmentioning

confidence: 97%

Untitled

2013

IJPSR

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The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area. Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7) with or without stearylamine (SA) or dicetylphosphate (DP) were prepared using reversed-phase evaporation and lipid film hydration methods respectively. The prepared liposomal systems were evaluated for their entrapment efficiency, morphological characters, physical stability, particle size and drug release rate .LUVs entrapped greater amount of drug than MLVs. Drug loading was increased by increasing CH content as well as by inclusion of SA into the lipid bilayer. Drug release rate showed an order of negatively > neutral > positively charged liposomes, which is the reverse of results of drug loading efficiency. Physical stability study indicated that 92. 56%, 84.11%, 76.41% and 91.1%, 82.19% and 75.54% of diclofenac sodium was retained in positive, negative, and neutral MLVs and LUVs respectively after storing for 120 days at refrigeration temperature. The in vivo anti-inflammatory activity was evaluated using a thermal technique , results showed that the percentage of healed ulcers were 12.5%, 35%, 67.5%, 82.5%, 85%, 87.5% and 95% for negative control, positive control, 0.5% carbopol 934 gel, LUVs liposomes suspension, MLVs liposomes suspension, LUVs and MLVs gels, respectively.

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Preparation and evaluation of a liposomal formulation of sodium cromoglicate

Cited by 41 publications

References 10 publications

Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

Ciprofloxacin as Ocular Liposomal Hydrogel

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