Preparation and encapsulation techniques of chitosan microsphere for enhanced bioavailability of natural antioxidants

Nah, Jae‐Woon; Jeong, Gyu-Seob

doi:10.1016/j.carres.2020.108218

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…CS is a biopolymer of biological origin naturally occurring in animals and plants (such as shrimp shells), which is obtained by the deacetylation reaction of chitin, and it is the only basic polysaccharide that exists in large quantities in the biological world [ 90 , 91 , 92 ]. It has naturally excellent antibacterial properties due to its functional group (amino group) [ 93 ].…”

Section: The Materials For Microspheresmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.

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Section: The Materials For Microspheresmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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“…They are produced continuously during normal physiological activities, but the overproduction can lead to cell damage, which in turn causes serious diseases such as cancer, hypertension, aging, atherosclerosis, and Alzheimer's disease. [35,36] Antioxidants can significantly reduce the accumulation of the free radicals and protect the body from damage. Chitosan oligosaccharide and its derivatives show certain radical scavenging activity and can serve as antioxidants to prevent various diseases caused by free radicals.…”

Section: Antioxidant Activitymentioning

confidence: 99%

The Antioxidant and Antibacterial Activities of the Pyridine‐4‐Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives

Zhang

Wang

et al. 2022

Starch Stärke

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As a reactive intermediate, chloracetyl chitosan oligosaccharide (CACS) can be nucleophilic substituted by some bioactive groups to give novel derivatives of chitosan oligosaccharide (COS). The Schiff bases of pyridine‐4‐aldehyde are grafted onto CACS to give four COS derivatives in this paper. Specific structural characterization is implemented by fourier‐transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). The degree of substitution (DS) of COS derivatives is quantitatively calculated by ratio of hydrogen proton integral. Their antioxidant property is evaluated using free radical scavenging assay towards 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and superoxide anion radicals, and the antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) is also investigated. The results revealed that the pyridine‐4‐aldehyde Schiff bases grafted chloracetyl chitosan oligosaccharide derivatives showed better antioxidant activity as well as antibacterial activity than COS and CACS, which may be related to the positive charge of these derivatives. Among all final products, derivative BPCACS with the highest DS has the best bioactivity with scavenging rate of 91.49% for the DPPH assay and inhibition diameter of 39.25 mm for S. aureus inhibitory assay, respectively. These results indicated that COS derivatives with enhanced biological activities could serve as potential biomaterial for antioxidant and antibacterial applications.

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“…• Bioactive oligosaccharides improve resistance to pathogens and overall antimicrobial properties of the capsule (Estevinho et al, 2013;Berger et al, 2014;Muxika et al, 2017;Nah and Jeong, 2021) Humic acid • Enhance nutrient uptake by encapsulated cells • Bio-stimulants • Improved encapsulation rates • Improved linkage between microorganisms and exopolysaccharides (Nesterenko et al, 2013;Elzoghby, Elgohary and Kamel, 2015;Colla et al, 2017;Casadesús, Polo and Munné-Bosch, 2019;Vejan et al, 2019;Valdivia-Rivera et al, 2021) Frontiers in Built Environment frontiersin.org…”

Section: Additive Encapsulation Advantages Referencesmentioning

confidence: 99%

Novel biodesign enhancements to at-risk traditional building materials

Booth

Jankovic²

2022

Front. Built Environ.

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Extreme weather conditions increase the frequency of regular maintenance on heritage buildings and cause erosion of traditional materials. Developments in bio-enhanced self-repair materials provide an opportunity to improve building performance and reduce the frequency of costly maintenance schedules. The microbial sequestration of carbon by bacteria, encapsulated and layered into several limewash coats, facilitates capturing atmospheric carbon and reduces carbon-generating maintenance regimes. The use of hydrogels, alginates and biofilm derived biopolymers as novel bacterial encapsulation and nutrient delivery vehicles is discussed and the opportunity to develop self-healing sacrificial limewash as a future research project. Microbial enhanced carbon-fixing limewash may also offer a broader application to improve the performance of sustainable materials such as hemp-lime bio-composites as a fast-forward projection of problems and solutions with these materials in the future.

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Preparation and encapsulation techniques of chitosan microsphere for enhanced bioavailability of natural antioxidants

Cited by 6 publications

References 42 publications

Application of Biomedical Microspheres in Wound Healing

Application of Biomedical Microspheres in Wound Healing

The Antioxidant and Antibacterial Activities of the Pyridine‐4‐Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives

Novel biodesign enhancements to at-risk traditional building materials

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