Preparation and characterizations of all-biodegradable supramolecular hydrogels through formation of inclusion complexes of amylose

Kadokawa, Jun‐ichi; Nomura, Shintaro; Kyutoku, Tsuyoshi

doi:10.1007/s00289-017-1972-8

Cited by 6 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amylose as a linear polysaccharide offers interesting properties due to its helical conformation which enables amylose to act as a host molecule. The guest molecules range from small molecules such as iodine to big molecules such as polymers . The complexation between amylose and polymer leads to a versatile approach to prepare block copolymers with the capability of self‐organizing.…”

Section: Introductionmentioning

confidence: 99%

Inclusion Complexes Between Polytetrahydrofuran‐b‐Amylose Block Copolymers and Polytetrahydrofuran Chains

Rachmawati

Woortman

Kumar

et al. 2015

Macromolecular Bioscience

View full text Add to dashboard Cite

Amylose inclusion complexes are prepared by complexation of synthetic amylose having a covalently attached PTHF block (PTHF-b-amylose) with guest polytetrahydrofuran of molecular weights of 650 and 1000 g · mol(-1) (PTHF650 and PTHF1000). Differential Scanning Calorimetry (DSC) analysis of the products shows a characteristic melting peak of the complexes at 140 °C. Compared to PTHF650, the PTHF1000 displays lower complexing ability with PTHF-b-amylose which is indicated by visible amylose retrogradation. The possible structures of the resulting products are estimated from Thermo Gravimetric Analysis (TGA) which reveals differences between PTHF-b-amylose and the corresponding complexes. In addition, X-Ray Diffraction (XRD) analysis demonstrates that the resulting structures of the complexes consist of 6-fold V-amylose helices. The results are confirmed further with Small Angle X-Ray Scattering (SAXS) diffractions which show that formation of inclusion complexes increases the crystalline size and regularity of the complex. There is a strong indication that the covalently attached PTHF block also induces the formation of V-amylose by residing in between the amylose blocks. In this case, the resulting structure of the complex is likely affected by both the complexation between amylose block and the added PTHF and by the in situ self-assembly of the block copolymers.

show abstract

Section: Introductionmentioning

confidence: 99%

Inclusion Complexes Between Polytetrahydrofuran‐b‐Amylose Block Copolymers and Polytetrahydrofuran Chains

Rachmawati

Woortman

Kumar

et al. 2015

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…To fabricate amylosic supramolecular soft materials comprising V-amylose segments, such as gels and films, by vine-twining polymerization, we have employed immobilized primers (maltoheptaose, G 7 ) or guest polymers as graft chains, which are covalently attached on suitable polymeric main chains. − With the progress of the vine-twining polymerization, amylosic inclusion complexes are formed with the graft chains among the main-chain polymers, which act as cross-linking points to construct supramolecular network structures, resulting in the formation of soft materials.…”

Section: Introductionmentioning

confidence: 99%

Formation of Supramolecular Soft Materials from Amylosic Inclusion Complexes with Designed Guest Polymers Obtained by Vine-Twining Polymerization

et al. 2019

Self Cite

View full text Add to dashboard Cite

Amylose forms supramolecular inclusion complexes with polymeric guests in the phosphorylase-catalyzed enzymatic polymerization field, so-called “vine-twining polymerization”. However, such inclusion complexes have not exhibited specific properties and processability as functional supramolecular materials. In this study, we found that amylosic inclusion complexes, which were obtained by vine-twining polymerization using a designed guest polymer, that is, an amphiphilic triblock copolymer poly(2-methyl-2-oxazoline- block -tetrahydrofuran- block -2-methyl-2-oxazoline), exhibited gel and film formation properties. The characterization results of the products suggested that enzymatically elongated amylose chains complexed with the polytetrahydrofuran block in the triblock copolymer. Accordingly, the outer poly(2-methyl-2-oxazoline) blocks constructed hydrophilic spaces among the inclusion complex segments. Furthermore, the presence of such outer blocks affected the lower regularity of crystalline alignment among the inclusion complex segments in the products. Such higher-order structures probably induced the formation of supramolecular soft materials, such as gels and films.

show abstract

“…The hydrogel is disrupted and reproduced through the β-amylase-catalyzed hydrolysis of amylose and the reformation of amylose through GP-catalyzed polymerization, respectively. Chitosan-graft-poly(ε-caprolactone) (chitosan-g-PCL) has also been used for the same approach to fabricate the amylosic supramolecular network at the nanoscale (Figure 7) [47]. Because the hydrogel produced entirely comprises biodegradable components, that is, amylose, PCL, and chitosan, it can be disrupted through the enzymatic hydrolysis of Chitosan-graft-poly(ε-caprolactone) (chitosan-g-PCL) has also been used for the same approach to fabricate the amylosic supramolecular network at the nanoscale (Figure 7) [47].…”

Section: Hierarchical Nanoarchitecture Of Amylosic Supramolecular Net...mentioning

confidence: 99%

“…Chitosan-graft-poly(ε-caprolactone) (chitosan-g-PCL) has also been used for the same approach to fabricate the amylosic supramolecular network at the nanoscale (Figure 7) [47]. Because the hydrogel produced entirely comprises biodegradable components, that is, amylose, PCL, and chitosan, it can be disrupted through the enzymatic hydrolysis of Chitosan-graft-poly(ε-caprolactone) (chitosan-g-PCL) has also been used for the same approach to fabricate the amylosic supramolecular network at the nanoscale (Figure 7) [47]. Because the hydrogel produced entirely comprises biodegradable components, that is, amylose, PCL, and chitosan, it can be disrupted through the enzymatic hydrolysis of respective components, catalyzed by β-amylase, lipase, and chitosanase.…”

Section: Hierarchical Nanoarchitecture Of Amylosic Supramolecular Net...mentioning

confidence: 99%

Fabrication of Nanostructured Supramolecules through Helical Inclusion of Amylose toward Hydrophobic Polyester Guests, Biomimetically through Vine-Twining Polymerization Process

Kadokawa

2023

Biomimetics

Self Cite

View full text Add to dashboard Cite

This review article presents the biomimetic helical inclusion of amylose toward hydrophobic polyesters as guests through a vine-twining polymerization process, which has been performed in the glucan phosphorylase (GP)-catalyzed enzymatic polymerization field to fabricate supramolecules and other nanostructured materials. Amylose, which is a representative abundant glucose polymer (polysaccharide) with left-handed helical conformation, is well known to include a number of hydrophobic guest molecules with suitable geometry and size in its cavity to construct helical inclusion complexes. Pure amylose is prepared through enzymatic polymerization of α-d-glucose 1-phosphate as a monomer using a maltooligosaccharide as a primer, catalyzed by GP. It is reported that the elongated amylosic chain at the nonreducing end in enzymatic polymerization twines around guest polymers with suitable structures and moderate hydrophobicity, which is dispersed in aqueous polymerization media, to form amylosic nanostructured inclusion complexes. As the image of this system is similar to how vines of a plant grow around a support rod, this polymerization has been named ‘vine-twining polymerization’. In particular, the helical inclusion behavior of the enzymatically produced amylose toward hydrophobic polyesters depending on their structures, e.g., chain lengths and substituents, has been systematically investigated in the vine-twining polymerization field. Furthermore, amylosic supramolecular network materials, such as hydrogels, are fabricated through vine-twining polymerization by using copolymers, where hydrophobic polyester guests or maltooligosaccharide primers are covalently modified on hydrophilic main-chain polymers. The vine-twining polymerization using such copolymers in the appropriate systems induces the formation of amylosic nanostructured inclusion complexes among them, which act as cross-linking points, giving rise to supramolecular networks at the nanoscale. The resulting materials form supramolecular hydrogels, films, and microparticles.

show abstract

Preparation and characterizations of all-biodegradable supramolecular hydrogels through formation of inclusion complexes of amylose

Cited by 6 publications

References 36 publications

Inclusion Complexes Between Polytetrahydrofuran‐b‐Amylose Block Copolymers and Polytetrahydrofuran Chains

Inclusion Complexes Between Polytetrahydrofuran‐b‐Amylose Block Copolymers and Polytetrahydrofuran Chains

Formation of Supramolecular Soft Materials from Amylosic Inclusion Complexes with Designed Guest Polymers Obtained by Vine-Twining Polymerization

Fabrication of Nanostructured Supramolecules through Helical Inclusion of Amylose toward Hydrophobic Polyester Guests, Biomimetically through Vine-Twining Polymerization Process

Contact Info

Product

Resources

About