Preparation and characterization of vanillin-crosslinked chitosan therapeutic bioactive microcarriers

Zou, Qin; Li, Junfeng; Li, Yubao

doi:10.1016/j.ijbiomac.2015.05.037

Cited by 56 publications

(40 citation statements)

References 45 publications

(51 reference statements)

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“…TED-loaded chitosan microspheres (10 mg) were added into 100 mL anhydrous alcohol and heated with reflux condensation at 80°C for 1 hour under magnetic stirring (15× g ). 24 After cooling down to room temperature and centrifugation, the amount of TED released in the solution was analyzed by means of HPLC analysis’. Drug loading (DL%) and entrapment efficiency (EE%) of drug-loaded microspheres were calculated according to equations (1) and (2) : 25

where W P , W M , and W F represent the weight of initial throwing in polymer, the weight of drug incorporated into microspheres, and the weight of initial throwing in drug, respectively.…”

Section: Methodsmentioning

confidence: 99%

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

Guo

Cang

2016

DDDT

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In this study, novel tetrandrine-loaded chitosan microspheres were prepared by the emulsion cross-linking method. The systems were then characterized for physicochemical properties and in vitro drug release. In addition, the pharmacokinetics and tissue distribution of microspheres were further verified in animal models. Particle-size distribution indicated that the size of microspheres was within the range of 7–15 μm, with a median diameter of 12.4 μm. The drug loading and entrapment efficiency of the formulation were 34.6%±12.5% and 87.3%±9.7% (mean ± SD), respectively. In vitro release showed a typical sustained and long-term drug release behavior. The Higuchi equation was the model that fit best with release data. Maintaining a relatively constant plasma concentration in the long-term drug treatment is an outstanding pharmacokinetic advantage of tetrandrine microspheres in vivo. Moreover, compared with tetrandrine solution, tetrandrine microspheres produced a lower drug concentration in the heart, liver, and kidneys. This indicated that the microspheres used in this study were preferable for targeting lung tissue versus other tissues. No damage to the tissues of the lung was found in histopathological examination.

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where W P , W M , and W F represent the weight of initial throwing in polymer, the weight of drug incorporated into microspheres, and the weight of initial throwing in drug, respectively.…”

Section: Methodsmentioning

confidence: 99%

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

Guo

Cang

2016

DDDT

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“…Vanillin is applied as the cross‐linker. The vanillin‐cross‐linked chitosan microspheres and beads could sustain the release of encapsulated active compounds such as drugs and EOs . The aldehyde groups in vanillin interact with the amino groups of chitosan and undergo a Schiff base reaction to form a strong network structure.…”

Section: Resultsmentioning

confidence: 99%

Effect of chitosan and alginate beads incorporated with lavender, clove essential oils, and vanillin against Botrytis cinerea and their application in fresh table grapes packaging system

Sangsuwan

Sutthasupa

2019

Packag Technol Sci

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Encapsulation of clove, lavender essential oils (EOs)m and vanillin into chitosan (CH) and alginate (AL) beads was prepared using a simple oil‐entrapped emulsion to inhibit Botrytis cinerea in table grapes. The overall encapsulation efficiency of AL beads was observed to be higher than that of CH beads. The release of EO from beads depended mostly on surrounding relative humidity. The inhibition efficiency of the beads was investigated with grapes packed in a clamshell by placing a permeable sachet containing beads inside and storing at 5°C for 28 days. Visible mould growth on the control grapes and grapes packed with CH beads containing clove EO was observed on Days 21 and 28, respectively. The grapes packed with AL beads containing clove EO were free from mould until Day 28. The qualities of the grapes during storage, including the CO2 and O2 concentration in the packaging, firmness, total soluble solids, titratable acidity, ascorbic acid content, and acceptability of grapes, were evaluated. The use of CH or AL beads releasing clove EO maintained the freshness, firmness, flavour, odour, and overall acceptability of the grapes better than the control.

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“…Previous studies have confirmed that vanillin, as an antimicrobial and an antioxidant, enhances the antibacterial effect in chitosan membranes and inhibits spoilage bacterial growth (Cava-Roda et al, 2012;Zou et al, 2015). Due to its special aromatic structure, vanillin has been successfully incorporated into other new polymers to expand its application (Li et al, 2016;Kamaraj et al, 2018).…”

Section: Introductionmentioning

confidence: 94%

Effect of the Combination of Vanillin and Chitosan Coating on the Microbial Diversity and Shelf-Life of Refrigerated Turbot (Scophthalmus maximus) Filets

Sun

Chen

et al. 2020

Front. Microbiol.

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The effect of the combination of vanillin and chitosan (VC) coating on the microbiota composition and shelf-life of turbot (Scophthalmus maximus) filets during a 15day storage period at 4 ± 1 • day was investigated in this study. The control and coated fish samples were analyzed periodically for sensory and chemical attributes [total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), and pH] and the presence of dominant spoilage microbiota. The results suggested that the sensory and the chemical quality of turbot filets effectively improved after treatment with vanillin (final concentration 2 mg/ml) combined with 1% chitosan, and the shelf-life was prolonged for 6 to 7 days compared with the control group. Furthermore, high-throughput sequencing showed that Proteobacteria (52.2%) and Firmicutes (29.8%) were the dominant bacteria at the phylum level in fresh turbot filets, while Pseudomonadaceae (40.2%) and Lactobacillaceae (39.4%) were the dominant bacteria at the family level in deteriorated turbot filets. However, after VC treatment, the relative abundance of Pseudomonadaceae and Lactobacillaceae decreased significantly due to the growth inhibition of potential bacteria, specifically spoilage bacteria, along with the rich bacterial diversity at the end of storage. Therefore, our data indicated that VC treatment might be effective in decreasing bacteria-induced quality deterioration and in extending the shelf-life of refrigerated turbot filets.

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Preparation and characterization of vanillin-crosslinked chitosan therapeutic bioactive microcarriers

Cited by 56 publications

References 45 publications

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

Effect of chitosan and alginate beads incorporated with lavender, clove essential oils, and vanillin against Botrytis cinerea and their application in fresh table grapes packaging system

Effect of the Combination of Vanillin and Chitosan Coating on the Microbial Diversity and Shelf-Life of Refrigerated Turbot (Scophthalmus maximus) Filets

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