Preparation and characterization of triclosan nanoparticles for periodontal treatment

Piñón-Segundo, Elizabeth; Ganem-Rondero, Adriana; Alonso-Pérez, V; Quintanar‐Guerrero, David

doi:10.1016/j.ijpharm.2004.11.010

Cited by 146 publications

(80 citation statements)

References 29 publications

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“…Better penetration of the active moiety into the junctional epithelium (site of action) combined with optimal drug release profiles are among the important benefits of this approach. Drug concentration in the periodontal tissue can be improved by incorporating the drug into controlled release delivery systems that can be placed locally in the periodontal pockets (Piñón-Segundo et al, 2005;Schwach-Abdellaoui et al, 2000). The local delivery of antimicrobial agents to the periodontal pockets has the benefit of the drug reaching the target site at low dose thus minimizing exposure of the drug in the entire body (Hau et al, 2014;Pragati et al, 2009).…”

Section: In Drug Deliverymentioning

confidence: 99%

“…Drug concentration in the periodontal tissue can be improved by incorporating the drug into controlled release delivery systems that can be placed locally in the periodontal pockets (Piñón-Segundo et al, 2005;Schwach-Abdellaoui et al, 2000). The local delivery of antimicrobial agents to the periodontal pockets has the benefit of the drug reaching the target site at low dose thus minimizing exposure of the drug in the entire body (Hau et al, 2014;Pragati et al, 2009). Local delivery systems with sustain release effect might also be applicable for areas with accessibility difficulties due to anatomical complexity or depth, as in furcation defects (Kornman, 1993).…”

Section: In Drug Deliverymentioning

confidence: 99%

“…Local delivery systems with sustain release effect might also be applicable for areas with accessibility difficulties due to anatomical complexity or depth, as in furcation defects (Kornman, 1993). Several studies have shown that an effective approach to optimize the targeting or to enhance the action of drugs is to associate the active moiety with a carrier system (Pramod et al, 2014). Some of the secarrier systems and their roles in periodontal disease therapy are summarized in Table 1.…”

Section: In Drug Deliverymentioning

confidence: 99%

“…The disease starts with anaerobic gram-negative bacterial invasion around the gingival sulcus (Kesavalu et al, 2007), which is a region between the teeth and the gums. Then the epithelium of the gingivae migrates along the tooth surface forming periodontal pockets, which if left untreated can lead to deposition of tar and calculus by the microbes and consequently results in the destruction of the tooth neighboring structures and loss of teeth (Pihlstrom et al, 2005;Pramod et al,2014;Tanner, 2015). Delivering drug to the gingival epithelium has been the major challenge for the formulation scientists due to the complexity of the anatomy of the route and the contours of the lesion which leads to the drug's poor penetration to the area (Schwach-Abdellaoui et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Many authors reported review articles about local drug delivery systems for the treatment of periodontal disease (Hau et al, 2014;Pragati et al, 2009;Puri and Puri, 2013;SchwachAbdellaoui et al, 2000), and few reviews have also discussed some applications of nanotechnology-based delivery systems in the treatment of the disease (Goyal et al, 2014;Zupancic et al,2015b). However, review articles that provide detail account on specific roles of various nanotechnology-based approaches for periodontal disease therapy are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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Section: In Drug Deliverymentioning

confidence: 99%

Section: In Drug Deliverymentioning

confidence: 99%

Section: In Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

Ahmed¹,

Mora-Huertas²,

Jaafar‐Maalej³

et al. 2013

Drug Delivery Strategies for Poorly Water‐Soluble Drugs

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Novel Triclosan-Bound Hybrid-Silica Nanoparticles and their Enhanced Antimicrobial Properties

Makarovsky¹,

Boguslavsky²,

Alesker³

et al. 2011

Adv. Funct. Mater.

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The design and synthesis of novel hybrid‐silica nanoparticles (NPs) containing the FDA‐approved antimicrobial triclosan (Irgasan) covalently linked within the inorganic matrix for its controlled, slow release upon interaction, is reported. The NPs are in the range of 130 ± 30 nm in diameter, with a smooth and spherical morphology. Characterization of the hybrid‐silica NPs containing triclosan, namely T‐SNPs, and their appropriate linkers is accomplished by microscopic and spectroscopic techniques. Preliminary antimicrobial activity is studied through bacterial‐growth experiments. The T‐SNPs are found to be superior in killing bacteria, as compared with the free biocide.

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Preparation and characterization of triclosan nanoparticles for periodontal treatment

Cited by 146 publications

References 29 publications

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

Novel Triclosan-Bound Hybrid-Silica Nanoparticles and their Enhanced Antimicrobial Properties

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