Preparation and Characterization of Tadpole- and Sphere-Shaped Hemin Nanoparticles for Enhanced Solubility

Yang, Jie; Xiong, Liu; Li, Man; Xiao, Jun-Xia; Geng, Xin; Wang, Baowei; Sun, Qingjie

doi:10.1186/s11671-019-2880-7

Cited by 17 publications

(6 citation statements)

References 22 publications

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“…During the self-assembly of H@Gd-NCPs, Hemin was uniformly integrated into Gd-NCPs via its carboxyl groups and conjugated π bonds, effectively avoiding the self-stacking and maintaining catalytic activity. Actually, Hemin could be found in blood and meat products and is widely used as oral iron supplement 60 . With the help of H 2 O 2 , H@Gd-NCPs enhanced the peroxidase-like enzymatic activity of Hemin and exhibited better GSH depletion ability than free Hemin (Fig.…”

Section: Discussionmentioning

confidence: 99%

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

et al. 2021

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Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic immune responses are very rare and insufficient to meet clinical needs. Here, we demonstrate a synergetic strategy for boosting radiation-induced immunogenic cell death by constructing gadolinium-hemin based nanoscale coordination polymers to simultaneously perform X-ray deposition and glutathione depletion. Subsequently, immunogenic cell death is induced by sensitized radiation to potentiate checkpoint blockade immunotherapies against primary and metastatic tumors. In conclusion, nanoscale coordination polymers-sensitized radiation therapy exhibits biocompatibility and therapeutic efficacy in preclinical cancer models, and has the potential for further application in cancer radio-immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

et al. 2021

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“…50 The FT-IR spectra also demonstrate the high content of hemin in MMN(HT). As shown in Figure S4, the unique peaks representing hemin molecules were observed strongly in MMN(HT), [51][52][53] F I G U R E 2 C1s peaks of A, MMN(LT); B, MMN(RT); and C, MMN(HT); and N1s peaks of D, MMN(LT); E, MMN(RT); and F, MMN(HT), measured by XPS whereas those vaguely appeared in MMN(LT) and MMT (RT). Shortly, the hemin content in MMN(HT) is higher than that of MMN(LT) and MMN(RT), meaning the high-temperature environment induced the strong bond between hemin and PEI as the results of Figure 3A.…”

Section: Uv-vis Spectrummentioning

confidence: 93%

High temperature‐induced myoglobin‐mimic catalytic structure having high axial ligand content for one‐compartment hydrogen peroxide fuel cells

Jeon

et al. 2021

Intl J of Energy Research

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A facile and inexpensive method of fabricating a myoglobin-mimic nanostructure is introduced by evaluating the influence of temperature conditions on the axial coordination between the Fe core of hemin and amine of polyethyleneimine (PEI). Through the high-temperature (100 C) synthesis condition, more hemin molecules are strongly attached to the carbon nanotube and PEI composite owing to the amide bond formation, whereas the energy distribution of hemin is deformed, and the electrical connection is improved by the coordination of axial ligands when the catalyst is synthesized on a lower temperature (25 C). Benefiting from the high concentration of axial ligands, the onset potential is positively shifted by 0.258 V, and the highest current density (155.43 μA cm À2 ) is observed with 10 mM H 2 O 2 under physiological conditions. These phenomena occur because of the different hydrogen peroxide reduction reaction (HPRR) mechanisms and the overpotential stemming from the effect of the axial ligand, which induces the lowest catalytic and charge transfer resistance for HPRR at 51 and 820 Ω cm À2 , respectively. In the polarization curves measured using a 3D printed membraneless flow-type fuel cell, the maximum power density reaches 129.0 μW cm À2 with 0.340 V of opencircuit voltage, respectively, which offers the best performance among the reported studies for the membraneless hydrogen peroxide fuel cells driving under physiological conditions so far.

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“…However, the high hydrophobicity owing to the large macrocycle of tetrapyrrole and the low solubility in the neutral aqueous phase hinders the biomedical use of hemin. 166 Specifically, for bone tissue engineering, how to load hemin onto the scaffold with high biological activity and utilization rate is an urgent problem to solve. 167 Using PDLLA as a medium, Dang et al 12 successfully integrated hemin particles and DOX into 3D-printed bioglass scaffolds.…”

Section: Anti-tumor Therapy Of 3d Scaffoldsmentioning

confidence: 99%

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

Liu,

Qiang

et al. 2023

J Tissue Eng

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Osteosarcoma is the most prevalent bone malignant tumor in children and teenagers. The bone defect, recurrence, and metastasis after surgery severely affect the life quality of patients. Clinically, bone grafts are implanted. Primary bioceramic scaffolds show a monomodal osteogenesis function. With the advances in three-dimensional printing technology and materials science, while maintaining the osteogenesis ability, scaffolds become more patient-specific and obtain additional anti-tumor ability with functional agents being loaded. Anti-tumor therapies include photothermal, magnetothermal, old and novel chemo-, gas, and photodynamic therapy. These strategies kill tumors through novel mechanisms to treat refractory osteosarcoma due to drug resistance, and some have shown the potential to reverse drug resistance and inhibit metastasis. Therefore, multifunctional three-dimensional printed bioceramic scaffolds hold excellent promise for osteosarcoma treatments. To better understand, we review the background of osteosarcoma, primary 3D-printed bioceramic scaffolds, and different therapies and have a prospect for the future.

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Preparation and Characterization of Tadpole- and Sphere-Shaped Hemin Nanoparticles for Enhanced Solubility

Cited by 17 publications

References 22 publications

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

High temperature‐induced myoglobin‐mimic catalytic structure having high axial ligand content for one‐compartment hydrogen peroxide fuel cells

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

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