Preparation and Characterization of Some Isoelectronic Boron-Nitrogen Analogs of Substituted Uracil [1]

Abstract

<jats:p>Several 1,3,5-triaza-2-boracyclohexa-4,6-diones, which are isoelectronic analogs of substituted uracil, have been prepared by condensation reactions of boranes with biurets. They include species containing a NH or BH unit as potentially reactive sites. The latter are extremely sensitive to hydrolysis but are readily handled as the 2-methylaminoethanol derivative containing fourcoordinate boron.</jats:p>

Synthesis and in vitro evaluation of boronated uridine and glucose derivatives for boron neutron capture therapy.

“…The resulting residue was purified by column chromatography (dichloromethane/methanol 7:1) and dried for 1 h at 100 °C under vacuum (0.5 mm). 9: yield 790 mg (87%) of white crystals; mp 145-147 °C; MS (FAB+, 3-NBA) 401 ( + H)+; -NMR (CDaOD) b 1.30-3.00 (br m, 10 , B-H), 3.70 (C^NABk,) C, , N, B.…”

“…Since the compound 7b was only a byproduct, no additional study was undertaken to confirm its structure or the characterization of its decomposition products. Compound 11 (Scheme III) was synthesized in 91% yield from l,2:5,6-di-0-isopropylidene-D-glucose (10) (Scheme III) by analogy with 7a and 7b.…”

Darstellung von 1,3,5-Trimethyl-4,6-dioxo-1,3,5,2λ3-triazaphosphinanen; Einkristall-Röntgenstrukturanalyse eines Platin(II)-Komplexes/Preparation of 1,3,5-Trimethyl-4,6-dioxo-1,3,5,2λ3-triazaphosphinanes; Single Crystal X-Ray Diffraction Study of a Platinum(II)-Complex

“…Es sind cyclische Biuret-Verbindungen von Bor [9][10][11][12], Silicium [10], Arsen [13] und Nickel [14] bekannt. Diese Verbindungen wurden nicht immer durch Umsetzungen von Biuret-Verbindungen, sondern auch aus Harnstoffen erhalten.…”