Darstellung von 1,3,5-Trimethyl-4,6-dioxo-1,3,5,2λ³-triazaphosphinanen; Einkristall-Röntgenstrukturanalyse eines Platin(II)-Komplexes/Preparation of 1,3,5-Trimethyl-4,6-dioxo-1,3,5,2λ³-triazaphosphinanes; Single Crystal X-Ray Diffraction Study of a Platinum(II)-Complex

Abstract

1,3,5-Trimethylbiuret, 1,3,5-Trimethyl-4,6-dioxo-1,3,5,2/.3-triazaphosphinane, X-Ray, Staudinger Reaction A new synthesis for 2-chloro-l,3,5-trim ethyl-4,6-dioxo-l,3,5,2A3-triazaphosphinane (1) is described. Chlorine-fluorine exchange in 1 by means o f sodium fluoride in acetonitrile in the presence of catalytic am ounts of a crown ether furnished 2-fluoro-l, 3,5-trimethyl-4,6-dioxol,3,5,2A3-triazaphosphinane (2). The synthesis of the bromine and iodine analogues, 3 and 4, by metathesis of 1 with the appropriate trimethylsilyl halides, M e3SiBr and Me3SiI, respective ly, is also described. The syntheses of an iron(0)tetracarbonyl complex (5) and of a dichloroplatinum(II) complex (6) Bei diesem N ebenprodukt handelt es sich um eine cyclische Phosphor-Biuret-Verbindung. Biuret-Verbindungen sind nahe Verwandte der H arn stoff-Verbindungen und unterscheiden sich von diesen formal lediglich durch eine zusätzliche RNCO-Gruppe.* Sonderdruckanforderungen an Prof. Dr. R. Schm utz ler.Verlag der Z eitschrift für N atu rfo rsch u n g , D-W -7400 T übingen 0 9 3 2 -0 7 7 6 /9 2 /0 4 0 0 -0517/$ 01.00/0 Unseres Wissens ist M eN[(0:)CNM e]2PCl (1) jedoch die bisher einzige cyclische z 3-P hosphorBiuret-Verbindung.

Synthesis and Antifungal Activity of Metal Complexes ContainingDichloro‐Tetramorpholino‐Cyclophosphazatriene

“…It is thus probable that these derivatives and the azole antifungal compounds, such as ketoconazole or itraconazole possess a similar mechanism of action at molecular level. 7,8 Materials and Methods Elemental analyses were done by combustion with a Carlo Erba Instrument or gravimetrically for the metal ions. Electronic spectra have been recorded at room temperature on a VSU-2G spectrophotometer Dichlorotetramorpholino-cyclophosphazatriene using MgO as standard material.…”

“…Synthesis of complexes of dichloro-tetramorpholino-cyclophosphazatriene (L) [1][2][3][4][5][6][7] All complexes have been synthesised according to the following general procedure: methanolic solutions containing the metal salts MX2.nH20 (M Co, Ni, Mn; X C1, AcO) and the ligand (L) were mixed with stirring in 1" 1, 2"1 and 3:2 molar ratios of M L. The resulting mixtures were refluxed for 60 min on a water bath. The complexes were separated by filtration, washed with diethylether and dried in a dessicator (on (13205)2).…”