Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug-loaded chitosan nanoparticles as a drug delivery system

Afshar, Mina; Dini, Ghasem; Vaezifar, Sedigheh; Mehdikhani, Mehdi; Movahedi, B.

doi:10.1016/j.jddst.2020.101530

Cited by 66 publications

(41 citation statements)

References 47 publications

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“…Current studies have shown a massive variation of applications and novel modifications of chitosan, thereby increasing its overall value. Drug encapsulation using chitosan with tripolyphosphate was first reported by Bodmeier et al [ 50 , 51 ] who used an inotropic gelation process, which results in the formation of chitosan nanoparticles. Chitosan (100–150 nm) nanoparticles were loaded with Rosuvastatin drug encapsulated in polyvinyl alcohol (PVA)/Sodium alginate (SA) core using an ionic gelation method.…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

“…The release behavior of the drug was observed within 24 h, and chitosan particles delivered significant results in the drug release process. This biocompatible and biodegradable drug delivery system was a suitable choice for replacing the various doses of the drug Rosuvastatin [ 51 ]. In 1998, Alonso et al synthesized the chitosan nanoparticle with the development of inter-and intra-molecular interaction between the chitosan amino group and tripolyphosphate (TPP).…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

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A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

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Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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“…ity [30], low toxicity [24,[31][32][33], good strength [34,35], and high water content [36][37][38]. Currently, the PVA-based materials are extensively utilized in the medical, industrial, and agricultural industries [39].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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“…They have wide applications in biomedical science including tissue engineering, drug delivery, 3D cell cultures, stem cell research, and in vitro diagnostics 3 . Currently, hydrogels are developed in various forms including discs, nanoparticles, 4 microparticles, 5 composites, 6 matrices, 7 coatings and films 8 based on desired utilization. Polymers like chitosan is a cationic polysaccharide having high molecular weight and composed of (1‐4)‐2‐amino‐2‐deoxy<beta>D‐glucan 9 .…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Rehman

Sarfraz

Mahmood

et al. 2021

Polymers for Advanced Techs

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This project was designed to develop pH responsive smart chitosan/agarose‐g‐poly (methacrylate) hydrogels using free radical polymerization for targeted delivery of Capecitabine (a prodrug of 5‐fluorouracil) for the treatment of colorectal cancer. Developed hydrogels were evaluated for drug loading efficiency, thermal stability, compatibility of components, morphology, swelling behavior, release kinetics and acute oral toxicity studies in rabbits. Moreover, pharmacokinetic parameters were also measured in healthy rabbits. Structural entanglement was confirmed via FTIR providing evidence of hydrogel formation. Loading of Capecitabine was in range from 60.35% to 62.57%. Hydrogels showed pH‐responsive behavior by providing maximum swelling of 93.84% at pH 7.4 identical to colon. Release of Capecitabine from hydrogels was in controlled pattern over a period of 36 h. Toxicity studies revealed no signs of ocular, dermal and oral toxicity providing safety evidence of hydrogels. In addition, pharmacokinetic evaluations of Capecitabine loaded hydrogels showed significant increase in plasma half‐life of 17 h and AUC of 57.65 μg.h/ml in comparison to pure Capecitabine solution. Therefore, these results strongly suggest that newly formed hydrogels are biocompatible, capable of providing sustained release at specific pH and can be employed as a cargo for colorectal delivery.

show abstract

Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug-loaded chitosan nanoparticles as a drug delivery system

Cited by 66 publications

References 47 publications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

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