Preparation and characterization of RGD-immobilized chitosan scaffolds

Ho, Ming‐Hua; Wang, Da-Ming; Hsieh, Hsun-Ping; Liu, Hwa‐Chang; Hsien, Tzu-Yang; Lai, Juin‐Yih; Hou, Lein-Tuan

doi:10.1016/j.biomaterials.2004.08.032

Cited by 204 publications

(146 citation statements)

References 36 publications

(52 reference statements)

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“…The RGD sequence is known to induce cell adhesion by binding to integrin, which activates the Rho GTPase pathway (Hansson et al, 2012b;Johansson & Söderhäll, 1989). It was shown that RGD immobilization on chitosan 3-D scaffolds leads to an enhanced cell adhesion and biocompatibility (Ho et al, 2005). Bound to the chitosan backbone, RGD is recognized by the adhesion receptors on the cell surface.…”

Section: Chitosan and Chitosan Derivatives Coupled To Peptidesmentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

462

215

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Chitosan and Chitosan Derivatives Coupled To Peptidesmentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

462

215

View full text Add to dashboard Cite

show abstract

“…The degradation rate also affects the biocompatibility as fast degradation rate results in amino sugars accumulation that may lead to inflammatory response. Chitosan samples with low DD may induce an inflammatory response, whereas chitosan samples with high DD do not because of the low degradation rate (Hirano, Tsuchida, & Nagao, 1989;Kurita, Kaji, Mori, & Nishiyama, 2000;Sashiwa, Saimoto, Shigemata, Ogawa, & Tokura, 1991). The degradation rate of chitosan can be influenced by physical parameters such as porosity, fiber diameter, blending with other polymers, or the use of cross-linking agents.…”

Section: Chitosan Biodegradabilitymentioning

confidence: 99%

“…Recently, combination ofpeptide and cellsto enhance nerve regeneration has been used to bridge 10-mm gaplesionin rat sciatic nerve.Laminin-coated chitosan conduit in combination with BMSCs results in enhancement of nerve regrowth, muscle mass maintaining, and functional recovery. BMSCs inhibitedneuronalcelldeathandoverturntheinflammatoryresponseinduced by long-term chitosan implantation promoting nerve regeneration (Hsu et al, 2013). Chitosan 3-glycidoxypropylmethyldiethoxysilane-cross-linked membranes have been used for peripheral nerve reconstruction in the rat sciatic nerve model, either alone or in combination with N1E-115 NSCs.…”

Section: Chitosan Conduits Combined With Cells For Pns Repairmentioning

confidence: 99%

“…This property has been used to prepare a nonviral vector gene delivery system (Mumper, Wang, Claspell, & Rolland, 1995). Among the different tissue organs, many studies have investigated the use of chitosan for repair, not only because of its biocompatibility, biodegradability, low toxicity, and cost but also because of its excellent potential for supporting three-dimensional organization of regenerating tissues (Evans et al, 1999;Ho et al, 2005;Ma et al, 2003;Madihally & Matthew, 1999;Novikova, Novikov, & Kellerth, 2003;Vasconcelos & GayEscoda, 2000). Here, we review the main chitosan-based bioengineering strategies for peripheral nerve and spinal cord injury (SCI) repair.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System

Gnavi

Barwig²,

Freier³

et al. 2013

International Review of Neurobiology

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Various biomaterials have been proposed to build up scaffolds for promoting neural repair. Among them, chitosan, a derivative of chitin, has been raising more and more interestamongbasicandclinicalscientists.Anumberofstudieswithneuronalandglial cellcultures haveshownthat thisbiomaterial has biomimetic properties,which make it a good candidate for developing innovative devices for neural repair. Yet, in vivo experimental studies have shown that chitosan can be successfully used to create scaffolds that promote regeneration both in the central and in the peripheral nervous system. In this review, the relevant literature on the use of chitosan in the nervous tissue, either alone or in combination with other components, is overviewed. Altogether, the promising in vitro and in vivo experimental results make it possible to foresee that time for clinicaltrialswithchitosan-basednerveregenerationpromotingdevicesisapproaching quickly.

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“…Chitosan scaffolds are promising materials for the design of tissue engineered systems owing to their low immunogenic activity, controlled biodegradability and porous structure (Ho et al, 2005;Ma et al, 2003;Madihally & Howard 1999). The influence of DA on the structural and biological properties of chitosan scaffolds for cell culture and tissue engineering was studied by Tiğli & Gümüsderelioglu (Tiğli et al, 2007).…”

Section: Tissue Engineeringmentioning

confidence: 99%