Preparation and characterization of quaternary ammonium chitosan hydrogel with significant antibacterial activity

Design, synthesis of novel starch derivative bearing 1,2,3-triazolium and pyridinium and evaluation of its antifungal activity

“…Once this electrostatic contact was accomplished by the hydrophilic region, the hydrophobic region proceeded to penetrate the hydrophobic bilayer to cause cell leakage and lysis (Anthierens, Billiet, Devlieghere, & Du Prez, 2012;Sajomsang, Gonil, & Tantayanon, 2009). This cascade could lead to the release of K + and cytoplasmic components, and finally caused the death of the cells (Fan et al, 2015). And the adhesion between biomolecular targets and pharmaceutical molecules generated by electrostatic and hydrophobic interactions might be much stronger than that produced by hydrogen bond interaction, which caused the higher inhibitory indices of starch derivative bearing 1,2,3-triazolium and pyridinium (III) compared with starch derivative bearing 1,2,3-triazole and pyridine (II).…”

Novel 1,2,3-triazolium-functionalized starch derivatives: Synthesis, characterization, and evaluation of antifungal property

“…The powerful disruptive effect of 1,2,3-triazolium-functionalized starch on the microorganism was probably based on electrostatic interaction of positively charged moieties of the cationic molecules and negatively charged components on microbial cell membrane (Hassan, 2015;Jia, Duan, Fang, Wang, & Huang, 2016;Khan, Ullah, & Oh, 2016;Ng et al, 2014). This electrostatic interaction could facilitate changes of permeation property of the membrane wall to provoke internal osmotic imbalances and also cause hydrolysis of the peptidoglycans in the microbial cell wall to the leakage of intracellular electrolytes and nutrients (Cai et al, 2015;Fan et al, 2015;Tawfik, Zaky, Mohammad, & Attia, 2015). Besides, the greater effect on microbial of this electrostatic interaction than hydrogen bond interaction could cause the higher inhibitory indices of 1,2,3-triazolium-functionalized starch derivatives compared with starch derivatives bearing 1,2,3-triazole.…”

N,N,N-Trimethyl Chitosan and Its Potential Bactericidal Activity: Current Aspects and Technological Applications

“…TMC fibers regarding chitosan fibers could significantly enhance the contraction and wound re-epithelialization toward the mouse embryo fibroblast cells, leading to the wound dressing potential [12]. TMC-materials showed higher water absorbance capacity and stronger bactericidal effect, suppressing excessive would maceration i.e., the eschar formation and chronic clinical events at only 12 days [12,14]. So, TMC fiber has potential to be used as components for wound healing performance.…”

“…These are designed for orthopedic application [19], formulation of dental resin [11], repair engineering and wound healing/cell growth [12,14] and food industry [1,8], among others.…”

“…TMC basedmaterials (thin films, beads, thermosensitive hydrogels, polyeletrolyte complexes, nanoparticles, etc.,) may be designed as drug delivery matrices [13], as building devices coated with bactericidal and cell growth potentials [12,14] and developing biodegradable membranes [15,16] with bactericidal action for use in food industry, among others. This paper highlights the latest issues concerning TMC antimicrobial potential, as well as, some TMC-based technological applications.…”