Preparation and Characterization of Pt-Doped Bi2MoO6 Nanocomposites and Its High PDT Efficiency on HL60 Cells

Abstract

In this study, Pt-doped Bi2MoO6 nanocomposites were prepared by solvothermal and in situ reduction method. We used XRD, UV-Vis spectroscopy, TEM, EDS, and XPS to characterize its chemical properties. Results showed that the Pt-doped Bi2MoO6 nanocomposites had advantages of small size, good dispersion, and wide spectral response range. Then, we tested its biological toxicity and PDT efficiency on HL60 cells. Both pure Bi2MoO6 and Pt-doped Bi2MoO6 nanocomposites showed great biocompatibility after coincubated with leukemia cells for 12 h in the dark. As to PDT efficiency, Pt-doped Bi2MoO6 had a better-inactivated effect than pure Bi2MoO6. Furthermore, the PDT efficiency went up when atomic ratios and concentration increased. While the atomic ratio was 5% and the concentration was 1000 μg/mL, it reached the highest value at 85.2%. At last, we briefly analyzed the photocatalysis mechanism, which demonstrated that it was a potential photosensitizer with high efficiency for treating leukemia.

Effective Nanocomposite Based on Bi2MoO6/MoS2/AuNRs for NIR-II Light-Boosted Photodynamic/Chemodynamic Therapy

“…Figure a shows the main peaks of BMO at 10.8, 28.4, 32.6, 33.1, 35.8, 46.5, 47.1, 55.4, 56.4, and 58.4°, which are, respectively, corresponding to (020), (131), (200), (060), (151), (202), (062), (133), (191), and (262) planes indexed to the orthorhombic phase of BMO (JCPDS card no. 77-1246). , The XRD pattern of the BMO-MSA composite has two peaks at 38.5 and 44.2°, which are attributed to (111) and (200) planes of Au . The peaks at 13.7 and 46.5° are assigned to (002) and (105) planes of MoS 2 , respectively .…”

“…77-1246). 27,34 The XRD pattern of the BMO-MSA composite has two peaks at 38.5 and 44.2°, which are attributed to (111) and (200) planes of Au. 33 The peaks at 13.7 and 46.5°are assigned to (002) and (105) planes of MoS 2 , respectively.…”