Preparation and characterization of porous membranes of glucomannan and silver decorated cellulose nanocrystals for application as biomaterial

Lopes, Laise Maia; Germiniani, Luiz G. L.; Neto, João Batista Maia Rocha; Andrade, Patrícia Fernanda; Silveira, G.A.T. da; Taketa, Thiago Bezerra; Gonçalves, Maria do Carmo; Beppu, Marisa Masumi

doi:10.1016/j.ijbiomac.2023.126236

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…Thanks to these properties, it has been approved by the US Food and Drug Administration as a safe polymer for biological experiments. Due to its physicochemical properties, such as high chemical and thermal resistance, solubility in water and other non-toxic organic solvents, it can be easily processed into the form of nanofibers using electrospinning technique [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Sierakowska-Byczek,

Radwan-Pragłowska,

Janus

et al. 2024

Polymers

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Tissue engineering constitutes the most promising method of severe peripheral nerve injuries treatment and is considered as an alternative to autografts. To provide appropriate conditions during recovery special biomaterials called nerve guide conduits are required. An ideal candidate for this purpose should not only be biocompatible and protect newly forming tissue but also promote the recovery process. In this article a novel, multilayered biomaterial based on polyvinylpyrrolidone, collagen and chitosan of gradient structure modified with conductive nanoparticles is presented. Products were obtained by the combination of electrospinning and electrospraying techniques. Nerve guide conduits were subjected to FT-IR analysis, morphology and elemental composition study using SEM/EDS as well as biodegradation. Furthermore, their effect on 1321N1 human cell line was investigated by long-term cell culture. Lack of cytotoxicity was confirmed by XTT assay and morphology study. Obtained results confirmed a high potential of newly developed biomaterials in the field of nerve tissue regeneration with a special focus on injured nerves recovery.

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Section: Introductionmentioning

confidence: 99%

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Sierakowska-Byczek,

Radwan-Pragłowska,

Janus

et al. 2024

Polymers

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“…Different substances are incorporated into cellulose and derivatives to contribute to the antimicrobial action of dressings, such as natural oils, − metal ions, − or a mixture with antimicrobial polymers. − Nanomaterials, particularly graphene oxide (GO) and its composites, have intrinsic properties that make them suitable for biomedical applications. These materials exhibit high specific surface area, biocompatibility, and hydrophilicity.…”

Section: Introductionmentioning

confidence: 99%

Bacteria-Derived Cellulose Membranes Modified with Graphene Oxide-Silver Nanoparticles for Accelerating Wound Healing

Luz,

da Silva,

Marques

et al. 2024

ACS Appl. Bio Mater.

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This study reports on the modification of bacterial cellulose (BC) membranes produced by static fermentation of Komagataeibacter xylinus bacterial strains with graphene oxide-silver nanoparticles (GO-Ag) to yield skin wound dressings with improved antibacterial properties. The GO-Ag sheets were synthesized through chemical reduction with sodium citrate and were utilized to functionalize the BC membranes (BC/GO-Ag). The BC/GO-Ag composites were characterized to determine their surface charge, morphology, exudate absorption, antimicrobial activity, and cytotoxicity by using fibroblast cells. The antimicrobial activity of the wound dressings was assessed against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The results indicate that the BC/GO-Ag dressings can inhibit ∼70% of E. coli cells. Our findings also revealed that the porous BC/GO-Ag antimicrobial dressings can efficiently retain 94% of exudate absorption after exposure to simulated body fluid (SBF) for 24 h. These results suggest that the dressings could absorb excess exudate from the wound during clinical application, maintaining adequate moisture, and promoting the proliferation of epithelial cells. The BC/GO-Ag hybrid materials exhibited excellent mechanical flexibility and low cytotoxicity to fibroblast cells, making excellent wound dressings able to control bacterial infectious processes and promote the fast healing of dermal lesions.

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Construction of self‐healing gallium (III)‐cross‐linked konjac glucomannan/polyacrylamide hydrogels for efficiently killing bacteria and accelerating wound healing

Xu,

Sun,

Zhang

et al. 2024

J of Applied Polymer Sci

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Gallium ions have a special action mechanism that interferes bacterial iron metabolism, thereby possessing great potential for the treatment of bacterial infections. In this work, gallium ions‐cross‐linked konjac glucomannan/polyacrylamide (KGM/PAM/Ga3+) hydrogels are successfully constructed with satisfactory swelling ability, appropriate mechanical properties and adjustable degradation performance. Ga ions as a kind of cross‐linking agent can enhance the stability, and more importantly, improve the bactericidal ability of hydrogel, thus forming novel functional KGM/PAM/Ga3+ hydrogels for treating wounds. After the evaluation of antibacterial activity and biocompatibility, KGM/PAM/Ga3+ hydrogels can effectively inhibit the proliferation of bacteria through the gradual and sustainable release of Ga ions from the hydrogel with negligible cytotoxicity and good blood compatibility. Furthermore, they possess exceptional self‐healing behavior, and can be readily adapted to varying degrees of bending, which matches skin wound dressing application. Finally, the results of wound healing performance and histological evaluation demonstrate that KGM/PAM/Ga3+ hydrogels can efficiently accelerate infected wound healing and facilitate the regeneration of skin tissues.

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Preparation and characterization of porous membranes of glucomannan and silver decorated cellulose nanocrystals for application as biomaterial

Cited by 5 publications

References 57 publications

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Environment-Friendly Preparation and Characterization of Multilayered Conductive PVP/Col/CS Composite Doped with Nanoparticles as Potential Nerve Guide Conduits

Bacteria-Derived Cellulose Membranes Modified with Graphene Oxide-Silver Nanoparticles for Accelerating Wound Healing

Construction of self‐healing gallium (III)‐cross‐linked konjac glucomannan/polyacrylamide hydrogels for efficiently killing bacteria and accelerating wound healing

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