Preparation and characterization of polyvinyl alcohol/β‐cyclodextrin/GO‐Ag nanocomposite with improved antibacterial and strength properties

Abstract

In this work, new hydrogel films based on polyvinyl alcohol (PVA) and β-cyclodextrin (β-CD) were prepared with the aim of studying their ability as an antibacterial and drug carrier system. Gallic acid (GA) was used as an antibacterial drug which was encapsulated into the β-CD cavity, and finally, β-CD inclusion complex (GA/βCD-IC) was prepared. On the other hand, silver nanoparticles (AgNPs) were synthesized on the graphene oxide (GO) surface (GO-Ag), and the obtained GO-Ag was used to enhance the antibacterial properties and mechanical strength of their films. FT-IR and DSC analysis approved the formation of cross-linking with glutaraldehyde between the PVA and β-CD. Hydrogel films were characterized using XRD and SEM. The disc diffusion method showed the antibacterial activity for the films containing GO-Ag and GA. Due to the good strength, elasticity, WVP, and swelling ability, PVA/GA/βCD-IC/GO-Ag can be proposed as a potential antibacterial drug delivery system.

Nanocomposite Furcellaran Films—the Influence of Nanofillers on Functional Properties of Furcellaran Films and Effect on Linseed Oil Preservation

“…Graphene oxide (GO) is a single-layer nanomaterial with the high surface area, prepared from natural graphite and it has high oxygen content. It has many rich oxygen-containing functional groups (e.g., hydroxyl, epoxide, and carboxyl) in its structure that can interact with the biopolymer matrix [21,22]. The addition of GO increases the mechanical strength and the moisture barrier of the film [23,24].…”

Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers

“…formulation was obtained by incorporation and loading of these materials in β-CD and GO, separately. Hydrogel lm comprising PVA/GA@βCD/Ag-GO demonstrated improved tensile strength (>126.2 MPa), sustained and slower GA release over 2 h and higher antibacterial activity towards E. coli and S. aureus compared to PVA/GA@βCD and PVA/βCD (Pooresmaeil and Namazi 2019). Hydroxypropyl-βCD (HP-βCD) with solubility of 45% (w/v), as another derivative of β-CD, has been used as a delivery system to increase the solubility of therapeutic agents in aqueous media of biological conditions (Wei et al 2017); 1 wt% AgNPs in NFs of AgNPs-HP-βCD showed 11.6 and 10.7 mm for S. aureus and E. coli, respectively.…”

Design and fabrication of photoactive imidazole-based poly(ether-imide)s and a polyimide/HBP-modified SiO2 composite: toward high heat-resistance, antimicrobial activity and removal of heavy metal ions

“…Nowadays, polymer nanocomposites (PNCs) have received extensive attention in the eld of science and technology, owing to the combination of properties of inorganic nanomaterials and polymeric matrices. [1][2][3] Nano-silica (SiO 2 ) has been widely applied in polymer composites as an amplier thanks to enjoying several desirable properties including environmental compatibility, affordability, non-toxicity, excellent thermal stability, and capability of enhancing the mechanical properties of the polymeric matrix; hence PNCs based on SiO 2 nanollers have sparked huge interest in recent years. [4][5][6] Nonetheless, monotonous distribution and dispersion of nanollers all over the polymer matrix and adequate interaction between the two corresponding phases (matrix and ller) is one of the main requirements when preparing polymeric nanocomposites.…”