Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers

Abstract

The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk broin, carrageenan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attaining the advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for theses polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers.Herein, recent advances, present challenges and future perspective for AgNPs incorporated nanocomposites (NCs) are discussed to realize ideal antibacterial activities by exploiting the abundant natural biopolymers.

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

“…The addition of solid organic or inorganic nanoparticles (NPs) to synthetic polymers or biopolymers can provide new properties in addition to antimicrobial activity [53][54][55][56]. Among these NPs, formulations composed of silica NPs (SiO2) and polymers have been shown to improve the mechanical and antimicrobial properties of catheters, prosthetic inserts, blood bags, and other medical devices [57].…”

Antisense RNA, the modified CRISPR-Cas9, and metal/metal oxide nanoparticles to inactivate pathogenic bacteria

“…Metal and metal oxide NPs encompassing silver, zinc oxide (ZnO), copper (Cu), and titanium dioxide (TiO2) have attained more attention to inactivate microorganisms specifically bacteria compared to other nanomaterials [25,26]. Metal ion release from these NPs and production of reactive oxygen species (ROS) are considered as main antibacterial mechanisms [27,28]. According to the above discussion, here, these three new strategies are presented to get a deep insight into future researches.…”

Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications

“…Silver as a metal has been used since ancient times due to its microbicidal and/or anti-inflammatory properties (Assis et al, 2020;Alavi and Varma, 2021;Salesa et al, 2021). As a result, it has become a key NP of easy obtention through green biosynthesis by endophytic microorganisms.…”