Preparation and characterization of pH sensitive crosslinked Linseed polysaccharides-co-acrylic acid/methacrylic acid hydrogels for controlled delivery of ketoprofen

Shabir, Farya; Erum, Alia; Tulain, Ume Ruqia; Hussain, Muhammad Ajaz; Ahmad, Mahmood; Akhter, Faiza

doi:10.1080/15685551.2017.1368116

Cited by 46 publications

(34 citation statements)

References 30 publications

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“…Swelling Studies. The swelling ratio (dynamic swelling) of copolymers was performed up to 72 h, and equilibrium swelling of copolymers was continued for 2-3 weeks until a constant weight was achieved in 100 mL buffer solutions of different pH, respectively [25,26]. Dynamic and equilibrium swelling was calculated from the following formulas:…”

Section: Synthesis Of Artemisia Vulgaris-aammentioning

confidence: 99%

“…where W1 is the initial weight of dried disc of copolymer and W0 is the weight of the dried insoluble part of copolymer after extraction with water [24,26].…”

Section: Synthesis Of Artemisia Vulgaris-aammentioning

confidence: 99%

“…where F t shows the amount of Vildagliptin released at any time t and F load shows the quantity of a drug that was loaded in copolymer discs [26]. 2.17.…”

Section: Determination Of Surface Morphology By Scanningmentioning

confidence: 99%

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Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

Kausar

Erum

Tulain

et al. 2021

Advances in Polymer Technology

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This study investigated the use of Artemisia vulgaris L. seed mucilage as a new excipient for sustained delivery of Vildagliptin. Copolymeric carrier of A. vulgaris seed mucilage-co-AAm was devised by using acrylamide (AAm) as a monomer, methylene-bis-acrylamide (MBA) as a crosslinker, and potassium persulfate (KPS) as an initiator through free radical polymerization. Different formulations of A. vulgaris-co-AAm were devised by varying contents of polymer, monomer, crosslinking agent, initiator, and reaction temperature. Copolymeric structures were characterized through XRD analysis, Fourier transform infrared (FTIR) spectroscopy, TGA and DSC analysis, and scanning electron microscopy. Porosity, gel fraction, and Vildagliptin loading capacity of copolymers were also established. Swelling and in vitro drug release studies were conducted. XRD evaluation showed the alteration of the crystalline structure of Vildagliptin into an amorphous form. FTIR analysis confirmed the successful grafting of AAm to A. vulgaris seed mucilage backbone. Porosity was increased with increasing polymer concentration and reaction temperature while it was decreased with an increasing amount of AAm, MBA, and KPS. Gel content was decreased with increasing polymer concentration and reaction temperature while it was increased with an increasing amount of AAm, MBA, and KPS. Acute oral toxicity of copolymeric network was done in animal models to evaluate the safety. Copolymers showed the same swelling behavior at all pH 1.2, 4.5, 6.8, and 7.4. Vildagliptin release from copolymer showed a cumulative trend by increasing polymer content and reaction temperature, while a declining trend was observed with increasing contents of monomer, crosslinking agent, and initiator. Sustained release of Vildagliptin was observed from copolymers and release followed the Korsmeyer-Peppas model. From the acute oral toxicity studies, it is evident that newly synthesized copolymeric carriers are potentially safe for eyes, skin, and vital organs.

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Section: Synthesis Of Artemisia Vulgaris-aammentioning

confidence: 99%

“…where W1 is the initial weight of dried disc of copolymer and W0 is the weight of the dried insoluble part of copolymer after extraction with water [24,26].…”

Section: Synthesis Of Artemisia Vulgaris-aammentioning

confidence: 99%

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Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

Kausar

Erum

Tulain

et al. 2021

Advances in Polymer Technology

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“…Diffusion co-efficient represent the quantity of the solvent that diffuses through a unit area of the gel in unit time through concentration gradient [31]. Following parameters depends on the partial mobility of the solvent, that can be determined by the following equation 4:…”

Section: Diffusion Co-efficientmentioning

confidence: 99%

Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology

Akhlaq¹,

Ullah²,

Nawaz³

et al. 2020

Preprint

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The purpose of current research work was to formulate and typify gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel which would be highly pH-responsive and can able to accomplish targeted delivery of methotrexate in order to treat the colo-rectal pathologies. The primed gel/pva hydrogel discs were subjected to various physicochemical techniques i.e. swelling, diffusion co-efficient, sol-gel analysis and porosity using three altered sorts of pH (1.2, 6.8 & 7.4) phosphate buffer solutions for assessment/evaluation, and their characterization was done through Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA). Shape alteration and controlled methotrexate of release of Gel/PVA hydrogel have been done using three type of pH (1.2, 6.8 & 7.4) phosphate buffer mediums. Methotrexate was loaded through in-situ drug loading method due to hydrophobicity. Different kinetic models (first order & zero order kinetic), Higuchi model and Krosmere peppas model/Power law were applied to manipulate the drug release data. Physicochemical evaluation tests and drug release profile results were found insignificant (p< 0.05) in various pH mediums and dependent upon polymers concentration pH of medium and cross-linker amount. Kinetic model disclosed that release of methotrexate from Gel/PVA hydrogel follow non-Fickian diffusion method. It became concluded from this research work that release of methotrexate Gel/PVA hydrogel in targeted colon area can be achieved for treating colo-rectal disorders.

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“…The pH-dependent response of acrylic acid-based polymers were also investigated as controlled drug carrier systems. A polymeric matrix comprising Linseed (Linum usitatissimum), L. hydrogels (LSH) was prepared by free radical copolymerization rout between acrylic and methacrylic (MAA) acids using N, N -methylene bis-acrylamide (MBA) as a crosslinking agent, and investigated as drug carrier of ketoprofen by Shabir et al [32] It was found that swelling of the copolymer hydrogels was the greatest at pH 7.4. The extent of ketoprofen release was found to increase as the monomer content increased, and decreasewhen the MBA content decreased.…”

Section: Introductionmentioning

confidence: 99%

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

Alghamdi

Alsolami

Saeed

et al. 2018

Designed Monomers and Polymers

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A series of poly(acrylic acid)/poly(methyl vinyl ketone) (PAA/PMVK) blends with different compositions were prepared by the solvent casting method. The miscibility of this pair of polymers was investigated by differential scanning calorimetry(DSC), Fourier transform infra-red (FTIR) and X-Ray diffraction (XRD) techniques. An in-vitro cytotoxicity test of the drug-carrier system via MTT (3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed no significant cytotoxic effects at concentrations up to 100 µg· ml−1. The STX/PAA-50 drug carrier systems were also prepared by solvent casting of solutions containing the sulfamethoxazole (STX) used as drug model and PAA/PMVK blend in N.N-dimethylformamide then crosslinked with acidified ethylene glycol. The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated. According to the total gastrointestinal transit time estimated by Belzer, the estimate distribution of STX released in the different organs indicated that the performance is obtained with the drug – carrier-system containing equal ratios of polymer and 10 wt% of STX (STX-10/PAA-50).

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Preparation and characterization of pH sensitive crosslinked Linseed polysaccharides-co-acrylic acid/methacrylic acid hydrogels for controlled delivery of ketoprofen

Cited by 46 publications

References 30 publications

Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

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