Preparation and characterization of PEG-modified polyurethane pressure-sensitive adhesives for transdermal drug delivery

Abstract

These experimental results indicated that PEG-PU-PSAs have good potential for applications in TDDS.

Antifouling polyurethanes to fight device-related staphylococcal infections: synthesis, characterization, and antibiofilm efficacy

“…Other than polysaccharides, hydrophilic synthetic polymers, particularly PEG (Park et al, 1998;Orban et al, 1999; Chen et al, 2009;Rana et al, 2010), were also investigated as antifouling coatings for polyurethane-based medical devices. Although PEG possesses unique properties of nontoxicity and biocompatibility, the main limitation associated with its grafting to the polymer surface is the poor resistance to hydrolysis (Shen et al, 2002), a possible cause of coating detachment.…”

“…Notwithstanding the presence of soft domains that are hydrophilic and flexible, polyurethanes, if not properly functionalized, are not able to effectively counteract bacterial adhesion. Their coating or grafting with hydrophilic polymers is the most common strategy to improve their surface wettability (Orban et al, 1999;Sagnella & Mai-Ngam, 2005;Perrino et al, 2008;Chen et al, 2009;Rana et al, 2010) and thus their antiadhesive properties vs. bacteria (Park et al, 1998;Morra & Cassinelli, 1999). Overall, very few data are available on the ability of these functionalized polyurethanes to control microbial adhesion on and surface colonization of medical devices.…”

Polyurethane for biomedical applications: A review of recent developments

“…Besides the regular polyurethane materials, many environmental sensitive polyurethanes were also developed as drug controlled release carriers, such as temperature sensitive polyurethane Sun et al, 2011), pH sensitive polyurethane and pressure sensitive polyurethane (Chen et al, 2009), and so on. Apart from the controlled release of a specifi c drug from a polyurethane matrix, simultaneous drug release at different rates from biodegradable polyurethane foams were also reported (Sivak et al, 2009); the anti-cancer compounds DB-67 and doxorubicin were covalently incorporated into polyurethane foams and their release behaviors demonstrated that differential release of covalently bound drugs is possible from simple single-phase, degradable polyurethane foams.…”

New Waterborne Polyurethane-Urea Synthesized with Ether-Carbonate Copolymer and Amino-Alcohol Chain Extenders with Tailored Pressure-Sensitive Adhesion Properties

“…On the other hand, waterborne polyurethane PSAs without crosslinker have been synthesized with PPGs of different molecular weights and hydroxyl-terminated polybutadienes [12], and an increase of the storage modulus was found when the molecular weight of the PPG increased, and an increase in tack resulted when the amount of polybutadiene increased. In recent research, Akram et al [13,14] have studied the influence of the isocyanate and the polyol on the adhesion properties of waterborne polyurethane PSAs made with HTPB and 1,4-butanediol chain extender.In a different approach, Chen et al [15] have synthesized waterborne polyurethane PSAs intended for transdermal drug delivery by using the prepolymer method. Polyethylene glycol (PEG)-modified…”