Preparation and Characterization of Oral Nanosuspension Loaded With Curcumin

Hirlekar, Sneha Dekate Shreeram; Bhairy, Srinivas; Hirlekar, Rajashree

doi:10.22159/ijpps.2018v10i6.22027

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…The data obtained as output from the Zetasizer 7.12 series software (Malvern Panalytical, UK). Measurements were adapted from previous studies with slight modifications [18,24].…”

Section: Determination Of Particle Size Zeta Potential and Electropmentioning

confidence: 99%

Chitosan Nanoparticle as a Delivery System for Polyphenols From Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity

Pratiwi¹,

Martien

Murwanti

2019

Int J App Pharm

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Objective: This study aims to formulate meniran extract into polymeric nanoparticles. Better stability of active substances in formulas compared to unformulated extracts is expected to increase immunomodulatory activity. Methods: Nanoparticles were formulated using ionic gelation method with chitosan and tripolyphosphate polymers. Optimize the mixture of nanoparticles using simplex lattice design (SLD) with the help of Design-Expert (DX) software. Evaluation of particle size and potential zeta using dynamic light scattering (DLS). Interactions between components were analyzed using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR) and morphology of the lyophilization results observed using scanning electron microscopy (SEM). Immunomodulatory tests using the latex assay method. The parameters tested included phagocytosis index, phagocytic activity, and nitric oxide secretion. Results: The optimum mixture of the formulation process was obtained in the composition of chitosan 0.270 %, extract 0.626 %, and tripolyphosphate 0.074 % with desirability value of 0.841. Optimal response with particle size 434.7±3.90 d. nm, polydispersity index 0.285±0.03 and entrapment efficiency 62.98±0.65 %. The zeta potential value in the optimum formula is 11.9±0.1 mV with a positive charge. Phagocytosis index and phagocytic activity of nanoparticles differed significantly (p<0.05) compared with unformulated extracts. Conclusion: Meniran extract was successfully formulated into polymeric nanoparticles using chitosan-tripolyphosphate polymer. The developed nanoparticles have the immunomodulatory activity that is better than unformulated extract.

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“…The data obtained as output from the Zetasizer 7.12 series software (Malvern Panalytical, UK). Measurements were adapted from previous studies with slight modifications [18,24].…”

Section: Determination Of Particle Size Zeta Potential and Electropmentioning

confidence: 99%

Chitosan Nanoparticle as a Delivery System for Polyphenols From Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity

Pratiwi¹,

Martien

Murwanti

2019

Int J App Pharm

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“…The process of lyophilisation was employed to remove moisture content from samples matrix. Lyophilised samples were sputter coated with gold–palladium to make them electrically conductive (Athira & Jyothi, 2014; Chhouk et al ., 2018; Chatterjee et al ., 2022). SEM micrographs were taken at various magnifications to observe curcuma particle size and shape.…”

Section: Methodsmentioning

confidence: 99%

Curcuma particle size evolution by application of bead milling process and curcuminoids content determination

Lapčíková,

Valenta,

Lapčík

et al. 2023

Int J of Food Sci Tech

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SummaryThe aim of this research was to investigate the effect of curcuma dispersion bead milling on particle size evolution over time. The study of 10 wt.% and 20 wt.% curcuma dispersions revealed that dispersions’ polydispersity was decreasing up to 180 min which was found to be the optimum milling time with the volume mean diameter (d4,3) of (11.47 ± 0.85) μm. This diameter was the most effective with respect to the curcuma powder coagulation process attributed to the effect of curcuma oils after the milling time of 180 min. The mechanochemically atomized curcuma was used as a potential source of curcuminoids. By differential scanning calorimetry (DSC), two endothermic peaks were observed and related to curcuma melting effects. Curcumin powder exhibited one broad melting peak at 176 °C. Obtained data indicated that effective mechanochemical treatment makes curcuma powder a highly beneficial supplement applicable in food matrices of the human diet.

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“…The notable observation of particle size reduction from the micron to nanometer range signifies the success of the nanosuspension formulation in achieving a significant reduction in particle size. This reduction is crucial for enhancing the surface area and dissolution rate of the drug, potentially leading to improved bioavailability [31].…”

Section: Fig 5: Zeta Potential Of the Optimized Formulation Ns6mentioning

confidence: 99%

Development and Optimization of a Dolutegravir Nanosuspension Using Box Behnken Design

GOTTEMUKKULA,

PATHURI

2024

Int J App Pharm

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Objective: This study aimed to develop and optimize a nanosuspension of Dolutegravir, an integrase inhibitor with low aqueous solubility, using the sonoprecipitation technique. The objective was to enhance the drug's solubility and oral bioavailability by preparing nanosuspension. Methods: A box-behnken design was employed to systematically investigate the impact of stabilizer concentration, sonication amplitude, and time on the particle size and polydispersibility of the nanosuspension formulations. Various stabilizers, including Soluplus®, Poloxamer 188, Poly Vinyl Pyrrolidone (PVP) K90, Hydroxy Propyl Methyl Cellulose (HPMC), and Tween 80, were evaluated. Fourier transform infrared spectroscopy confirmed drug-polymer interactions, while differential scanning calorimetry and X-ray diffraction revealed partial amorphization. Scanning electron microscopy confirmed nanoscale particle size and morphology. Results: The optimized formulation (NS6) with 1% Soluplus®, 65 W amplitude, and 10 min sonication exhibited nanoparticles of 75.3 nm with low polydispersity. NS6 demonstrated enhanced drug release compared to the pure drug, attributed to particle size reduction and amorphization. In vitro tests indicated acceptable stability over time and temperature. Conclusion: The application of Box-Behnken design resulted in an optimized nanosuspension formulation capable of improving the oral bioavailability of poorly soluble Dolutegravir. The formulation exhibited favorable characteristics, including reduced particle size, amorphization, and enhanced drug release, highlighting its potential as an effective delivery system for Dolutegravir in Human Immuno Deficiency Virus (HIV) treatment.

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Preparation and Characterization of Oral Nanosuspension Loaded With Curcumin

Cited by 13 publications

References 10 publications

Chitosan Nanoparticle as a Delivery System for Polyphenols From Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity

Chitosan Nanoparticle as a Delivery System for Polyphenols From Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity

Curcuma particle size evolution by application of bead milling process and curcuminoids content determination

Development and Optimization of a Dolutegravir Nanosuspension Using Box Behnken Design

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