Preparation and characterization of novel tamarind gum-based hydrogels for antimicrobial drug delivery applications

Sharma, V.; Patnaik, P. S. R.; Senthilguru, K.; Nayak, Suraj Kumar; Syed, Irshaan; Singh, Vinay Kumar; Sarkar, Preetam; Thakur, Goutam; Pal, Kunal

doi:10.1007/s11696-018-0414-x

Cited by 14 publications

(11 citation statements)

References 42 publications

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“…TGP have 1735 kDa molecular weight [ 3 ]. It is a water-soluble, nonionic, branched polysaccharide with hydrophilic, gel-forming, and mucoadhesive characteristics [ 4 ]. TGP is also biodegradable, biocompatible, noncarcinogenic, and irritant-free.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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“…Due to its distinct advantageous properties, TG is used as the polymer in the fields of cosmetic and food industry [4,19,21,41] . Recent studies showed that TG forms an excellent hydrogel by physical crosslinking, which makes it suitable for topical drug delivery [42,43] .…”

Section: Chemistry and Properties Of Tamarind Gummentioning

confidence: 99%

“…TG hydrogels were thermostable in nature and formed spreadable hydrogels. The prepared hydrogels have capacity to retard drug release for longer time in its active form and showed good antimicrobial activity [42] . Further, TG has been used in combination with carboxymethylcellulose (CMC) for synthesis of citric acid crosslinked hydrogel dressings.…”

Section: Hydrogelsmentioning

confidence: 99%

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Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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“…This plant is native to India, Bangladesh, America and South Asian countries. TGP is used in food, textile industry and pharmaceutical applications as a drug carrier system 9 . It is hydrophilic, highly viscous, mucoadhesive, biocompatible, non‐carcinogenic and thermally stable.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

et al. 2022

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Purpose of this study was to prepare chitosan/tamarind crosslinked poly (methacrylic acid) hydrogels for pH responsive delivery of cytarabine by using aqueous free radical polymerization technique. Polymers were chemically cross-linked with monomer (methacrylic acid) using methylene bisacrylamide as cross-linking agent and ammonium per sulphate as a reaction initiator in aqueous medium. Developed hydrogels were characterized for morphology, physical existence, drug loading (%), compositional and structural analysis, thermal behavior and stability, drug release analysis (pH 1.2 and pH 7.4), and in vivo release kinetics. pH sensitive behavior was established by observing swelling and release behavior at different pH values (1.2 and 7.4). Biocompatibility of network was evaluated through acute oral toxicity studies in rabbits. Results revealed that cytarabine was efficiently loaded in prepared hydrogels with an entrapment efficiency of 54.67%-108.59%. Highest swelling ratio of 38.67 was noticed at pH 7.4. Maximum pH sensitive behavior was seen at pH 7.4 showing maximum drug release up to 94.51%. All developed formulations followed zero order release as confirmed from regression coefficient (R 2 = 0.9912-0.9991). In-vivo studies confirmed enhanced bioavailability of cytarabine. Histopathological examination and hemocompatibility studies proved that developed hydrogel system was safe, biocompatible, nonhemolytic in nature exhibiting no symptoms of dermal, ocular toxicities, and no changes in biochemical parameters of blood and histology of key organs. So, developed hydrogel system can be employed as an excellent drug delivery device where controlled drug delivery is desired.

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Preparation and characterization of novel tamarind gum-based hydrogels for antimicrobial drug delivery applications

Cited by 14 publications

References 42 publications

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

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