Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents

Abstract

Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation. In the present study, naproxen sodium nanoparticles were prepared by desolvation technique using various desolvating agents (butanol and combinations of acetonitrile and butanol), and two methods (continuous addition method and intermittent addition method) were adapted to decide the best desolvating agent. Obtained formulations were characterized and evaluated. The combination of acetonitrile and butanol as desolvating agent was giving good and promising results with good stability -40.7 mV and least mean particle diameter of 437.7 nm. From the results it was concluded that intermittent addition was the better method than continuous addition method for preparing naproxen sodium nanoparticles. The drug release was sustained till 12 h with 96.92% for nanoparticles prepared by intermittent addition method following zero order release with non-fickian diffusion mechanism.

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

“… 68 Based on the literature study ( Table 2 ), six studies discussed optimization by varying the ratio of drug: BSA. According to Abd Ellah et al 69 Jenita, Wilson, and Chocalingam, 70 Spada et al 71 Jenita, 72 and Syed and Sailaja 73 the particle size and polydispersity index value increase with the amount of BSA used. This is in accordance with previous studies also stating that the higher the concentration of BSA, the larger the particle size and the greater the polydispersity index.…”