Preparation and Characterization of Nanoliposomes Entrapping Medium-Chain Fatty Acids and Vitamin C by Lyophilization

Yang, Shiyou; Liu, Chengmei; Liu, Wei; Yu, Haipeng; Zheng, Huijuan; Zhou, Wei; Hu, Yaqin

doi:10.3390/ijms141019763

Cited by 62 publications

(25 citation statements)

References 43 publications

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“…As presented, the liposomes exhibited some significant differences (p50.05) in the increment of average diameter over eight weeks of storage at 4 C, from 193.33 ± 0.12 to 222.40 ± 8.80 nm, which is equivalent to a 15.1% increase. It is considered relatively stable compared to liposomes loaded with medium-chain fatty acids and vitamin C, which recorded a size increment of 33.0% over 60 days storage at the same condition (4 C), as reported by Yang et al (2013). The zeta potential of our liposomes has also increased over the study period, giving a value of À58.40 ± 0.32 mV at week 8 (Table 3).…”

Section: Storage Stability Study (8 Weeks)supporting

confidence: 49%

Preparation and characterisation of nanoliposomes containing winged bean seeds bioactive peptides

Chay

Tan

Saari

2015

Journal of Microencapsulation

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The aim of this study was to produce and characterise nanosize liposomes containing bioactive peptides with antioxidative and ACE-inhibitory properties, derived from winged bean seeds (WBS) protein. WBS powder was papain-proteolysed, at 70 °C and pH 6.5 for six hours, followed by encapsulation via a solvent-free heating method. The results showed that the WBS proteolysate was successfully incorporated into spherical, unilamellar liposomal particles, with particle diameter, polydispersity index, zeta potential and encapsulation efficiency of 193.3 ± 0.12 nm, 0.4 ± 0.02 (unit less), -70.5 ± 0.30 mV and 27.6 ± 1.17%, respectively. It also demonstrated good storage stability over eight weeks at 4 °C, indicated by slight increment (15.1%) in particle size and a zeta potential only weaker by 17.2% at the end of the study period. These results suggested the feasibility of entrapping water soluble peptides in hydrophobic liposomal system that, upon optimisation, has the potential to act as bioactive food ingredient.

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Section: Storage Stability Study (8 Weeks)supporting

confidence: 49%

Preparation and characterisation of nanoliposomes containing winged bean seeds bioactive peptides

Chay

Tan

Saari

2015

Journal of Microencapsulation

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“…However, preparation of nanoliposome-based delivery systems is challenging using traditional methods because of difficulties in generating small particle sizes and ensuring high entrapment efficiency. 24 Several factors impact the physicochemical performance of liposomes, including the nature of the phospholipids used to fabricate them. For example, soybean lecithin contains high amounts of C18:2 and C18:3, and is susceptible to hydrolysis of the ester bonds and peroxidation of the unsaturated acyl chains, 22 producing off-flavors and oxidation of the bioactive encapsulated within the liposomes.…”

Section: Introductionmentioning

confidence: 99%

Design, Fabrication, Characterization, and In Vitro Digestion of Alkaloid-, Catechin-, and Cocoa Extract-Loaded Liposomes

Toro-Uribe

Ibáñez

Decker³

et al. 2018

J. Agric. Food Chem.

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Liposomes containing theobromine, caffeine, catechin, epicatechin, and a cocoa extract were fabricated using microfluidization and sonication. A high encapsulation efficiency and good physicochemical stability were obtained by sonication (75% amplitude, 7 min). Liposomes produced at pH 5.0 had mean particle diameter ranging from 73.9 to 84.3 nm. The structural and physicochemical properties of the liposomes were characterized by transmission electron microscopy, confocal fluorescence microscopy and antioxidant activity assays. The release profile was measured by Ultra-High Performance Liquid Chromatography coupled to diode array detection. The bioaccessibility of the bioactive compounds encapsulated in liposomes was determined after exposure to a simulated in vitro digestion model. Higher bioaccessibilities were measured for all catechins-loaded liposome formulations compared to non-encapsulated counterparts. These results demonstrated that liposomes are capable of increasing the bioaccessibility of flavan-3-ols, which may be important for the development of nutraceuticalenriched functional foods.

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“…296 In addition, vitamin C nanoliposomes had enhanced stability and higher antioxidant activity compared to ordinary liposomes after 60 days of storage. 297 In another study, a vitamin C and gold-loaded nanofiber mask were prepared for the effective delivery of vitamins to the face. The liposomal preparation delivery of vitamins through mask enhanced facial beauty.…”

Section: Nanovitamin Cmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

122

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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Preparation and Characterization of Nanoliposomes Entrapping Medium-Chain Fatty Acids and Vitamin C by Lyophilization

Cited by 62 publications

References 43 publications

Preparation and characterisation of nanoliposomes containing winged bean seeds bioactive peptides

Preparation and characterisation of nanoliposomes containing winged bean seeds bioactive peptides

Design, Fabrication, Characterization, and In Vitro Digestion of Alkaloid-, Catechin-, and Cocoa Extract-Loaded Liposomes

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

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