Preparation and characterization of keratin-based biosheet from bovine horn waste as wound dressing material

Singaravelu, Sivakumar; Ramanathan, Giriprasath; Raja, M. D.; Barge, Sagar; Sivagnanam, Uma Tirichurapalli

doi:10.1016/j.matlet.2015.03.088

Cited by 37 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Sivagnanam et al, also using horn keratin, observed that the use of larger amounts of chitosan, from 50% to 75%, increased the tensile strength (from 7.40 to 21.14 MPa) and the tensile modulus (from 0.46 to 3.15 MPa), while decreasing the elongation at break (from 16.03% to 6.19%). They also observed the drug release effect of the blend, where in vitro release of the topical antibiotic Mupirocin indicated a burst release of 32% within the first hour, followed by sustained release at the end of 92 h (64%) [288].…”

Section: Chitosanmentioning

confidence: 95%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

View full text Add to dashboard Cite

Among the biopolymers from animal sources, keratin is one the most abundant, with a major contribution from side stream products from cattle, ovine and poultry industry, offering many opportunities to produce cost-effective and sustainable advanced materials. Although many reviews have discussed the application of keratin in polymer-based biomaterials, little attention has been paid to its potential in association with other polymer matrices. Thus, herein, we present an extensive literature review summarizing keratin’s compatibility with other synthetic, biosynthetic and natural polymers, and its effect on the materials’ final properties in a myriad of applications. First, we revise the historical context of keratin use, describe its structure, chemical toolset and methods of extraction, overview and differentiate keratins obtained from different sources, highlight the main areas where keratin associations have been applied, and describe the possibilities offered by its chemical toolset. Finally, we contextualize keratin’s potential for addressing current issues in materials sciences, focusing on the effect of keratin when associated to other polymers’ matrices from biomedical to engineering applications, and beyond.

show abstract

Section: Chitosanmentioning

confidence: 95%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

View full text Add to dashboard Cite

show abstract

“…Singaravelu et al () synthesized a dual layer of freeze dried manufactured horn KFG, loaded with mupirocin and electrospun PG loaded with curcumin (KFG:M‐PG:C) nanofibrous scaffold for full‐thickness wound healing. They showed that both KFG:PG and dual drug‐loaded KFG:M‐PG:C scaffolds demonstrated high cell viability at the end of Day 7, and that KFG:M‐PG:C repairs significantly faster relative to the other treated (KFG:M‐PG and KFG‐PG:C) and control groups, which could be due to the combination effect of curcumin and mupirocin antibiotic (Singaravelu, Ramanathan, Raja, Barge, & Sivagnanam, ). The KFG:M‐PG:C nanofibrous scaffold showed excellent inhibitory activity against both S. aureus and Escherichia coli bacteria, while the KFG‐PG nanofibrous scaffold did not show any inhibition zone.…”

Section: In Vivo Woundsmentioning

confidence: 99%

“…Burn injuries are common skin wounds, often resulting in death due to infection. Infection is one of the most common complications and a serious risk of acute trauma (Cho, Kim, & Kwon, 2016;Singaravelu et al, 2015). Mo et al (2017)…”

Section: Burn Woundsmentioning

confidence: 99%

Curcumin nanofibers for the purpose of wound healing

Fereydouni

Darroudi

Movaffagh

et al. 2018

Journal Cellular Physiology

113

View full text Add to dashboard Cite

Poor wound healing is a highly prevalent clinical problem with, as yet, no entirely satisfactory solution. A new technique, termed electrospinning, may provide a solution to improve wound healing. Due to their large surface area to volume ratio and porosity, the nanofibers created by electrospinning are able to deliver sustained drug release and oxygen to the wound. Using different types of polymers with varying properties helps strengthening nanofiber and exudates absorption. The nanofibers appear to have an ideal structure applicable for wound healing and, in combination with curcumin, can blend the anti-inflammatory and antioxidant properties of curcumin into a highly effective wound dressing. The use of suitable curcumin solvents and the slow release of curcumin from the nanofiber help in overcoming the known limitations of curcumin, specifically its low stability and limited bioavailability.Here, we review the studies which have been done on synthesized nanofibers containing curcumin, produced by the electrospinning technique, for the purpose of wound healing.

show abstract

“…Noncosmetic uses of Keratin include use as a biopolymer in nanomaterials and in biomedical applications such as wound dressings, drug delivery, tissue engineering, and trauma and medical devices. 10-13,36,37…”

Section: Noncosmeticmentioning

confidence: 99%

Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics

Burnett¹,

Bergfeld²,

Belsito³

et al. 2021

Int J Toxicol

View full text Add to dashboard Cite

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 keratin-derived ingredients, which function mainly as skin and hair conditioning agents in personal care products. The Panel reviewed relevant data provided in this safety assessment and concluded that the 8 keratin-derived ingredients are safe in the present practices of use and concentration described in this safety assessment.

show abstract

Preparation and characterization of keratin-based biosheet from bovine horn waste as wound dressing material

Cited by 37 publications

References 14 publications

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Curcumin nanofibers for the purpose of wound healing

Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics

Contact Info

Product

Resources

About