Preparation and characterization of hydroxypropyl chitosan modified with collagen peptide

Fan, Lihong; Zou, Shengqiong; Ge, Hongyu; Xiao, Yong; Wen, Huigao; Feng, Han; Li, Meng; Nie, Min

doi:10.1016/j.ijbiomac.2016.07.093

Cited by 38 publications

(17 citation statements)

References 35 publications

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“…In this study, 0-50 mg/mL MSCP exhibited no cytotoxicity. However, 100 mg/mL MSCP showed slightly cytotoxic effect, which could be due to changes in the osmolarity of the culture solution (Fan et al 2016;Zhu et al 2014). The cytotoxic effect of MSCP is significantly lower than those of commercial products (Zhu et al 2014).…”

Section: Discussionmentioning

confidence: 91%

“…The cytotoxic effect of MSCP is significantly lower than those of commercial products (Zhu et al 2014). Different polymers, including carboxymethyl cellulose, carboxymethyl chitosan, and hydroxypropyl chitosan, have been conjugated with collagen peptides for applications in pharmaceutical and food industries (Fan et al 2014(Fan et al , 2016Zhu et al 2014). Some modifications of polymers grafted with collagen peptides, including carboxymethyl cellulose, carboxymethyl carrageenan, and hydroxypropyl chitosan, can even promote cell proliferation and cell viability.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Chen

Liang

et al. 2018

J Food Sci Technol

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Milkfish (), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP. Measurement of DPPH· and ABTS· + radical scavenging activities and cellular reactive oxygen species revealed the high antioxidant activities of MSCP. MSCP demonstrated anti-inflammatory activities by reducing lipoxygenase activity and nitric oxide (NO·) radicals. Moreover, DNA electrophoresis assay indicated that MSCP treatment can directly protect against cyclobutane di-pyrimidine production and DNA single-strand breaks, which are harmful effects of UV radiation and HO. Given its antioxidant, anti-inflammatory, and DNA-protective activities, MSCP has potential applications in cosmeceuticals and supplementary health food.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Chen

Liang

et al. 2018

J Food Sci Technol

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“…A microbial transglutaminase (MTGase) biocatalyst was used to graft collagen peptide (CollP) to hydroxypropyl chitosan (HPCS) for wound dressing applications. The degree of substitution on the HPCS/CollP complex affected the moisture-absorption and retention ability, and a mass ratio of 0.34 MTGase:HPCS displayed the optimum moisture-retention ability and cell viability [93]. These two processing approaches displayed improved physical and mechanical properties along with fluctuating BMP performance.…”

Section: Polymer Coating Grafting Solvent Evaporation and Solvent mentioning

confidence: 99%

Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings

et al. 2020

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Chitosan can form interpolymer complexes (IPCs) with anionic polymers to form biomedical platforms (BMPs) for wound dressing/healing applications. This has resulted in its application in various BMPs such as gauze, nano/microparticles, hydrogels, scaffolds, and films. Notably, wound healing has been highlighted as a noteworthy application due to the remarkable physical, chemical, and mechanical properties enabled though the interaction of these polyelectrolytes. The interaction of chitosan and anionic polymers can improve the properties and performance of BMPs. To this end, the approaches employed in fabricating wound dressings was evaluated for their effect on the property–performance factors contributing to BMP suitability in wound dressing. The use of chitosan in wound dressing applications has had much attention due to its compatible biological properties. Recent advancement includes the control of the degree of crosslinking and incorporation of bioactives in an attempt to enhance the physicochemical and physicomechanical properties of wound dressing BMPs. A critical issue with polyelectrolyte-based BMPs is that their effective translation to wound dressing platforms has yet to be realised due to the unmet challenges faced when mimicking the complex and dynamic wound environment. Novel BMPs stemming from the IPCs of chitosan are discussed in this review to offer new insight into the tailoring of physical, chemical, and mechanical properties via fabrication approaches to develop effective wound dressing candidates. These BMPs may pave the way to new therapeutic developments for improved patient outcomes.

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“…81 Rajendran et al 82 established a chitosan nanofiber scaffold via an electrospinning technique combined with a coculture system that consisted of hepatocytes and fibroblasts, and thus developed a new 3D liver model for the maintenance of long-term liver functions. To obtain better biocompatibility, chitosan can be further modified with other macromolecules, such as collagen, 83 gelatin, 78 alginate, 84 and heparin. 85 For example, Fan et al 86 proved that chitosan/galactosylated hyaluronic acid scaffolds were suitable for improving hepatocytes adhesion and maintaining liver function in a previous work.…”

Section: Natural Macromoleculesmentioning

confidence: 99%

Regulated differentiation of stem cells into an artificial 3D liver as a transplantable source

Chen

Xiao

2020

Clin Mol Hepatol

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End-stage liver disease is one of the leading causes of death around the world. Since insufficient sources of transplantable liver and possible immune rejection severely hinder the wide application of conventional liver transplantation therapy, artificial three-dimensional (3D) liver culture and assembly from stem cells have become a new hope for patients with end-stage liver diseases, such as cirrhosis and liver cancer. However, the induced differentiation of single-layer or 3D-structured hepatocytes from stem cells cannot physiologically support essential liver functions due to the lack of formation of blood vessels, immune regulation, storage of vitamins, and other vital hepatic activities. Thus, there is emerging evidence showing that 3D organogenesis of artificial vascularized liver tissue from combined hepatic cell types derived from differentiated stem cells is practical for the treatment of end-stage liver diseases. The optimization of novel biomaterials, such as decellularized matrices and natural macromolecules, also strongly supports the organogenesis of 3D tissue with the desired complex structure. This review summarizes new research updates on novel differentiation protocols of stem cell-derived major hepatic cell types and the application of new supportive biomaterials. Future biological and clinical challenges of this concept are also discussed.

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Preparation and characterization of hydroxypropyl chitosan modified with collagen peptide

Cited by 38 publications

References 35 publications

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings

Regulated differentiation of stem cells into an artificial 3D liver as a transplantable source

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