Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Chen, Yu-Pei; Liang, Chia-Hua; Wu, Hongtan; Pang, Haiyue; Chen, Chuan; Wang, Guey‐Horng; Chan, Leong‐Perng

doi:10.1007/s13197-018-3148-4

Cited by 51 publications

(41 citation statements)

References 34 publications

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“…Previous studies also reported that collagen subunits contain multiple host defense peptides [ 47 ]. What is more, some collagen-derived peptides have antioxidant and anti-inflammatory capacities [ 48 ], and even can suppress allergic responses [ 49 ]. In this present study, multiple collagen subunits aroused our attention since their mapping ratios are much higher compared with other proteins.…”

Section: Discussionmentioning

confidence: 99%

High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets

Zhang

et al. 2018

Marine Drugs

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Antihypertensive peptides (AHTPs) are a group of small peptides with the main role to block key enzymes or receptors in the angiotensin genesis pathway. A great number of AHTPs have been isolated or digested from natural food resources; however, comprehensive studies on comparisons of AHTPs in various species from the perspective of big data are rare. Here, we established a simplified local AHTP database, and performed in situ mapping for high throughput identification of AHTPs with high antihypertensive activity from high-quality whole proteome datasets of 18 fish species. In the 35 identified AHTPs with reported high activity, we observed that Gly-Leu-Pro, Leu-Pro-Gly, and Val-Ser-Val are the major components of fish proteins, and AHTP hit numbers in various species demonstrated a similar distributing pattern. Interestingly, Atlantic salmon (Salmo salar) is in possession of far more abundant AHTPs compared with other fish species. In addition, collagen subunit protein is the largest group with more matching AHTPs. Further exploration of two collagen subunits (col4a5 and col8a1) in more fish species suggested that the hit pattern of these conserved proteins among teleost is almost the same, and their phylogeny is consistent with the evolution of these fish species. In summary, our present study provides basic information for the relationship of AHTPs with fish proteins, which sheds light on rapid discovery of marine drugs or food additives from fish protein hydrolysates to alleviate hypertension.

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Section: Discussionmentioning

confidence: 99%

High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets

Zhang

et al. 2018

Marine Drugs

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“…() and Chen et al . (). They obtained higher anti‐oxidation active peptides firstly and found that the substance also possessed anti‐inflammatory ability.…”

Section: Resultsmentioning

confidence: 97%

Osteoarthritis‐alleviating effects in papain‐induced model rats of chicken cartilage hydrolysate and its peptide fractions

Yang

Sun‐Waterhouse

Xiao

et al. 2019

Int J of Food Sci Tech

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This study aims to discover natural bioactive substances as alternative therapies to current medical and surgical treatments for osteoarthritis (OA). Chicken cartilage hydrolysate (CCH) was produced using trypsin and separated via ultrafiltration into CCH-I (molecular weight (MW) > 10 kDa) and CCH-II (MW <10 kDa). Results showed that CCH and its fractions (CCH-I and CCH-II) could relieve OA with different extents, and the outcome using these treatments depended on their especial composition. CCH-II (a fraction rich in low MW peptides with no chondroitin sulphate (CS) and low in sugar) exhibited desired OA-alleviating effect in papain-induced rat and highest in vitro antioxidant activities. CCH-I (a fraction rich in CS and in high MW peptides) might have an adverse effect on renal function. Therefore, it is industrially feasible to produce anti-inflammatory and antioxidative CCH, especially CCH-II, with the therapeutic potential for alleviating or treating OA. Further separation of CS from CCH-I may lead to a commercial pure CS product for treating OA.

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“…Oxidative stress and inflammation are intimately connected. Reactive oxygen species and reactive nitrogen species (RNS) are ubiquitous in the body and regulate cellular function when at healthy levels [ 14 , 70 ]. However, oxidative stress plays a central role in chronic inflammation when dysregulated [ 80 ].…”

Section: Fish and Shellfish-derived Anti-inflammatory Protein Products: Properties And Mechanismsmentioning

confidence: 99%

“…A large portion of harvested marine resources currently go to waste [ 12 ]. Around 60–70% of initial fish and shellfish weight is considered byproduct, and is utilized in low-value applications or discarded outright [ 13 , 14 , 15 ]. SPB consists of heads, frames, skin, shells, and viscera, much of which contain high-quality nutrients, including lipids, minerals, and protein [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms

Kemp

Kwon

2021

Molecules

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The interest in utilizing food-derived compounds therapeutically has been rising. With the growing prevalence of systematic chronic inflammation (SCI), efforts to find treatments that do not result in the side effects of current anti-inflammatory drugs are underway. Bioactive peptides (BAPs) are a particularly promising class of compounds for the treatment of SCI, and the abundance of high-quality seafood processing byproducts (SPB) makes it a favorable material to derive anti-inflammatory BAPs. Recent research into the structural properties of anti-inflammatory BAPs has found a few key tendencies including they tend to be short and of low molecular weight (LMW), have an overall positive charge, contain hydrophobic amino acids (AAs), and be rich in radical scavenging AAs. SPB-derived anti-inflammatory BAPs have been observed to work via inhibition of the NF-κB and MAPK pathways by disrupting the phosphorylation of IκBα and one or more kinases (ERK, JNK, and p38), respectively. Radical scavenging capacity has also been shown to play a significant role in the efficacy of SPB-derived anti-inflammatory BAPs. To determine if SPB-derived BAPs can serve as an effective treatment for SCI it will be important to understand their properties and mechanisms of action, and this review highlights such findings in recent research.

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Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Cited by 51 publications

References 34 publications

High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets

High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets

Osteoarthritis‐alleviating effects in papain‐induced model rats of chicken cartilage hydrolysate and its peptide fractions

Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms

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