Preparation and Characterization of Electrospun Polylactic Acid (PLA) Fiber Loaded with Birch Bark Triterpene Extract for Wound Dressing

Fan, Tian-Yuan; Daniels, Rolf

doi:10.1208/s12249-021-02081-z

Cited by 33 publications

(25 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electrospinning of PLLA resulted, reproducibly, in the fabrication of fibers with average fiber diameters of 1045 ± 320 nm (Figure 1a). The obtained diameters of the PLA fibers are in fairly good agreement with the literature data [34]. As can be easily seen using the selected conditions (concentration, solvent system, applied voltage, feeding rate, collector rotating speed, etc.…”

Section: Morphological Analysissupporting

confidence: 89%

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

et al. 2021

View full text Add to dashboard Cite

Nowadays, diseases in plants are a worldwide problem. Fungi represent the largest number of plant pathogens and are responsible for a range of serious plant diseases. Esca is a grapevine disease caused mainly by fungal pathogens Phaeomoniella chlamydospora (P. chlamydospora) and Phaeoacremonium aleophilum (P. aleophilum). The currently proposed methods to fight esca are not curative. In this study, polymer composites based on biodegradable polymer containing chemical fungicides with antifungal activity were successfully prepared by electrospinning. The obtained materials were hydrophobic with good mechanical properties. In vitro studies demonstrated that the fungicide release was higher from PLLA/K5N8Q fibrous mats (ca. 72% for 50 h) compared to the released drug amount from PLLA/5-Cl8Q materials (ca. 52% for 50 h), which is due to the better water-solubility of the salt. The antifungal activity of the fibrous materials against P. chlamydospora and P. aleophilum was studied as well. The incorporation of the fungicide in the biodegradable fibers resulted in the inhibition of fungal growth. The obtained materials are perspective candidates for the protection of vines from the penetration and growth of fungal pathogens.

show abstract

Section: Morphological Analysissupporting

confidence: 89%

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The nanoparticle is one of the best ways to increase the solubility and therapeutic efficacy of low-soluble bioactive therapeutics. There are various polymers used for the development of nanoparticles, like chitosan (CS) [ 15 ], polylactic acid [ 16 ] poly(lactic-co-glycolic acid) [ 17 ] alginate [ 18 ], pectin [ 19 ], gelatin [ 20 ], and Eudragit ® [ 21 ] etc. Among them, chitosan (CS) is a natural bio-macromolecules polymer.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation

Zafar

Alruwaili

Imam

et al. 2022

Sensors

View full text Add to dashboard Cite

Breast cancer is the most common cancer in females and ranked second after skin cancer. The use of natural compounds is a good alternative for the treatment of breast cancer with less toxicity than synthetic drugs. The aim of the present study is to develop and characterize hybrid Apigenin (AN) Nanoparticles (NPs) for oral delivery (AN-NPs). The hybrid AN-NPs were prepared by the self-assembly method using lecithin, chitosan and TPGS. Further, the NPs were optimized by Box-Behnken design (3-factor, 3-level). The hybrid NPs were evaluated for particle size (PS), entrapment efficiency (EE), zeta potential (ZP), and drug release. The optimized hybrid NPs (ON2), were further evaluated for solid state characterization, permeation, antioxidant, cytotoxicity and antimicrobial study. The formulation (ON2) exhibited small PS of 192.6 ± 4.2 nm, high EE 69.35 ± 1.1%, zeta potential of +36.54 mV, and sustained drug release (61.5 ± 2.5% in 24 h), as well as significantly (p < 0.05) enhanced drug permeation and antioxidant activity. The IC50 of pure AN was found to be significantly (p < 0.05) lower than the formulation (ON2). It also showed significantly greater (p < 0.05) antibacterial activity than pure AN against Bacillus subtilis and Salmonella typhimurium. From these findings, it revealed that a hybrid AN polymeric nanoparticle is a good carrier for the treatment of breast cancer.

show abstract

“…Incorporation of PLA in BC does not influence the crystalline morphology of BC, although a higher CI of 83.3% ± 4.3% was derived from the XRD analysis of BC/PLA composites [ 79 ]. Electrospun nanofibers containing BC functionalized with antimicrobial agents have shown enhanced antibacterial performance compared to traditional dressings [ 80 ] and are nowadays regarded as a promising wound dressing material due to their antibacterial, antiviral, and anti-inflammatory activities, as well as their ability to maintain an appropriate environment for wound healing [ 81 ].…”

Section: Antimicrobial Activities Of Bc Compositesmentioning

confidence: 99%

Bacterial Cellulose: Production, Characterization, and Application as Antimicrobial Agent

Lahiri

Nag

Dutta

et al. 2021

IJMS

129

View full text Add to dashboard Cite

Bacterial cellulose (BC) is recognized as a multifaceted, versatile biomaterial with abundant applications. Groups of microorganisms such as bacteria are accountable for BC synthesis through static or agitated fermentation processes in the presence of competent media. In comparison to static cultivation, agitated cultivation provides the maximum yield of the BC. A pure cellulose BC can positively interact with hydrophilic or hydrophobic biopolymers while being used in the biomedical domain. From the last two decades, the reinforcement of biopolymer-based biocomposites and its applicability with BC have increased in the research field. The harmony of hydrophobic biopolymers can be reduced due to the high moisture content of BC in comparison to hydrophilic biopolymers. Mechanical properties are the important parameters not only in producing green composite but also in dealing with tissue engineering, medical implants, and biofilm. The wide requisition of BC in medical as well as industrial fields has warranted the scaling up of the production of BC with added economy. This review provides a detailed overview of the production and properties of BC and several parameters affecting the production of BC and its biocomposites, elucidating their antimicrobial and antibiofilm efficacy with an insight to highlight their therapeutic potential.

show abstract

Preparation and Characterization of Electrospun Polylactic Acid (PLA) Fiber Loaded with Birch Bark Triterpene Extract for Wound Dressing

Cited by 33 publications

References 57 publications

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation

Bacterial Cellulose: Production, Characterization, and Application as Antimicrobial Agent

Contact Info

Product

Resources

About