Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications

Chen, Rui; Huang, Chen; Ke, Qinfei; He, Chang; Wang, Hongsheng; Mo, Xiumei

doi:10.1016/j.colsurfb.2010.03.043

Cited by 186 publications

(109 citation statements)

References 35 publications

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“…13a−c This sheath could improve the long time stability and mechanical strength of the biocompatible sheath, which was an unsettled problem of our previous study. 11 Conventionally the cross-linking process was carried out after electrospinning by GTA vapor or solution exposing, 12c, 16 and it would make the nanofibers thicker and melt into each other, resulting in a decrease of porosity and surface area (as seen in Figure 2B). In our study, the coaxial electrospinning with an in situ cross-linking process was carried out.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

Guan

2013

Anal. Chem.

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In vivo analysis poses higher requirements about the biocompatibility, selectivity and speed of analytical method. In this study, an in vivo fast equilibrium microextraction method was developed with a biocompatible core− sheath electrospun nanofiber membrane sandwiched within a microfluidic unit. The polystyrene/collagen core−sheath nanofiber membrane was coaxially electrospun and strengthened with in situ glutaraldehyde cross-linking. This membrane not only kept high mass transfer rate, large extraction capacity and biomatrix resistance as our previously proposed membrane (Anal. Chem. 2013, 85 (12), 5924−5932), but also got much better mechanical strength and stability in water. The microfluidic device was designed to sandwich the membrane, and the blood in vivo can be introduced into it and get contact with the membrane repetitively. With this membrane and device, a 2-min equilibrium in vivo extraction method was established, validated in a simulated blood circulation system, and was used to monitor the pharmacokinetic profiles of desipramine in rabbits. The free and total concentration of desipramine in vivo was monitored with 10-min interval almost without rabbit blood consumed. The results met well with those of in vitro extraction, and a correlation factor of 0.99 was obtained.

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Section: ■ Results and Discussionmentioning

confidence: 99%

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

Guan

2013

Anal. Chem.

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“…For example, it was difficult for most of the natural polymers to be electrospun; however, addition of a synthetic polymer could improve the Electrospun Polyurethane Nanofibers http://dx.doi.org/10.5772/intechopen.69937processability of these polymers [82]. PUs are easy to electrospin and they can be mixed either with a natural polymer or with a synthetic polymer [83,84,87] for special applications such as collagen [88], dextran [43], and hydroxypropyl cellulose (HPC) [41].…”

Section: Electrospinning Of Pu/blends and Pu Nanocomposite Nanofibersmentioning

confidence: 99%

“…Chen et al [88] produced collagen functionalized-TPU nanofibers (TPU/collagen) by coaxial electrospinning technique (Figure 9) with a goal to develop biomedical scaffold. 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) was used as solvent for collagen and TPU.…”

Section: Electrospinning Of Pu/blends and Pu Nanocomposite Nanofibersmentioning

confidence: 99%

Electrospun Polyurethane Nanofibers

Akduman¹,

Kumbasar²

2017

Aspects of Polyurethanes

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The electrospinning process is highlighted with the ability of fabricating fibers with diameters on the nanometer scale, small inter-fibrous pore size and high porosity, vast possibilities for functionalization with high surface area to volume or mass ratio, ease of use and instrument setup, and adaptability. It attracted a great deal of attention due to its unique properties. More than 100 different polymers have been successfully electrospun into ultrafine fibers using this technique including synthetic polymers such as polyurethane (PU). Electrospun PU nanofiber mats exhibiting good mechanical properties may have a wide variety of potential applications in high-performance air filters, protective textiles, wound dressing materials, sensors, drug delivery, etc. This chapter deals with the electrospinning of polyurethane nanofibers and their potential applications.

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“…Therefore, the PBS buffer/ethanol solvent system seems to be an alternative for electrospinning collagen with the application in tissue engineering. Fibers of blended collagen and other components, such as PEO [142], PCL [143], chitosan [144], polyurethane [145], and polydioxanone (PDO) [146], have also been prepared by electrospinning. Synthesized by the liver, fibrinogen is an important protein to the coagulation of blood [135].…”

Section: Protein Nanofibersmentioning

confidence: 99%

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

Han

Cheung

2011

Polymers

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Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants.

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Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications

Cited by 186 publications

References 35 publications

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

Electrospun Polyurethane Nanofibers

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

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