Preparation and characterization of chlorinated cross-linked chitosan/cotton knit for biomedical applications

Shin, Hyung Shik; Park, Mi‐Ra; Chung, Yong Sik; Kim, Hee Young; Jin, Fan‐Long; Choi, Hye-Jeong; Park, Soo‐Jin

doi:10.1007/s13233-013-1164-9

Cited by 25 publications

(7 citation statements)

References 24 publications

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“…In addition to the N -halamines that could be bonded to the fibrous substrates directly, many other substrates and N -halamines are not able to react with each other, a medium which serves as a bridge between N -halamines and fibrous materials is often required. Crosslinking agents, like 1,2,3,4-butanetetracarboxylic acid (BTCA) [ [91] , [92] , [93] , [94] , [95] , [96] , [97] ], dimethylol-5,5-dimethylhydantoin (DMDMH) [ 71 , 98 , 99 ], and citric acid [ 100 ], have been widely applied to react with N -halamines and fibers for the fabrication of NFMs due to their excellent chemical reactivity. For example, Li et al [ 101 ] attached N -halamine precursor compound, 2,2,6,6-tetramethyl piperidinol (TMP), onto cotton fabrics using BTCA as a crosslinker.…”

Section: Nfms Based On Surface Modificationmentioning

confidence: 99%

Antibacterial N-halamine fibrous materials

Wang

Huang

Zhang

et al. 2020

Composites Communications

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Section: Nfms Based On Surface Modificationmentioning

confidence: 99%

Antibacterial N-halamine fibrous materials

Wang

Huang

Zhang

et al. 2020

Composites Communications

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“…According to our knowledge, solely scarce information on the chitosan (CS) modified by a N -halamine can be found in a literature [ 38 , 39 , 40 , 41 , 42 , 43 ]. Each of mentioned works realizes different goals and concerns separate topics.…”

Section: Introductionmentioning

confidence: 99%

N-Halamine Hydantoin-Containing Chitosan: Synthesis, Characterization, Thermal and Photolytic Stability Studies

Chylińska

Kaczmarek

2020

Molecules

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Current demand for new protective materials ensuring sterility is systematically growing. The purpose of this work was the synthesis of the biocidal N-halamine hydantoin-containing chitosan (CS-CMH-Cl) and characterization of its properties. The functionalization of the chitosan by 5-hydantoinacetic acid substitution leads to obtaining the CS-CMH polymer, which was chlorinated in next step to transform N-H into N-Cl bonds. In this study, the possibility of forming two biocidal N-Cl bonds in hydantoin ring, grafted onto chitosan chains, was proved. The structure and stability of the prepared material was confirmed by spectroscopic (FTIR, NMR, colorimetric test) and microscopic analyses (SEM, AFM). Surface properties were investigated based on contact-angle measurements. In addition, the thermal and photochemical stability of the obtained samples were determined as functional features, determining the range of potential use. It was found that both modified chitosan polymers (CS-CMH and CS-CMH-Cl) were characterized by the smaller thermal stability and more hydrophilic and rougher surface than unmodified CS. Photooxidative degradation of the obtained materials was observed mainly on the sample surface. After irradiation, the surfaces became more hydrophilic—especially in the case of the CS-CMH-Cl—which is advantageous from the point of view of the antibacterial properties. Antibacterial tests against S. aureus and E. coli confirmed the antibacterial activities of received CS-CMH-Cl material.

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“…After Berliner revealed the success of N -halamines on water disinfection as early as in 1931, the development of antibacterial N -halamines has led to great advances. − It was proven that N -halamines could generate via a simple halogenation of the N–H bond-containing precursor (such as hydantoin, imidazolidinone, oxazolidinone, barbituric acid, chitosan, etc . ), which allow N -halamines to exhibit diversity in their molecular structure. − When the N-X bond is investigated, the halogen(s) in N -halamines can be chlorine, bromine, or iodine, with chlorine being the most popular. − Throughout the historical development of antibacterial N -halamines, most of the studies that related to antibacterial N -halamines concentrated mainly on N–Cl bond-containing N -halamines rather than N–Br (or N–I) bond-containing ones. Despite several reports pointed out the antibacterial effectiveness of N–Br bond-containing N -halamines, their antibacterial action against bacteria is not quite clear until now. − Accordingly, it is urgently need to uncover the mystic veil of the N–Cl bond-containing N -halamines.…”

Section: Introductionmentioning

confidence: 99%

Novel N–Br Bond-Containing N-Halamine Nanofibers with Antibacterial Activities

Bai

Kang

Simalou

et al. 2018

ACS Biomater. Sci. Eng.

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N-Halamine compounds have attracted great attention because they are recognized as promising antibacterial agents to control microbial contamination; however, most of the research interests were focused on N-halamines that contain N–Cl bond(s) rather than N–Br bond(s). In this contribution, we report the facile fabrication of N–Br bond-containing N-halamine nanofibers using the electrospinning method for antibacterial usages. The as-produced N–Br bond-containing N-halamine nanofibers (i.e., DBDMH/PAN nanofibers) comprise an antibacterial component of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and a support component of polyacrylonitrile (PAN). When systematic characterizations were carried out, the as-obtained DBDMH/PAN nanofibers were proven to exhibit well-defined fiber-like morphology and be highly efficient in the killing of the selected model bacteria (Escherichia coli). Their morphology and size could be well governed by tuning the concentration of electrospinning precursor and the mass ratio of PAN to DBDMH. The antibacterial mechanism of the DBDMH/PAN nanofibers and their stabilities under dry, wet, and bacterial conditions were confirmed as well. Facile synthesis and antibacterial activity allow the feasibility of the final N–Br bond-containing N-halamine nanofibers for antibacterial-related clinical applications in practice. Our work highlights the development of the N–Br bond-containing N-halamine nanofibers as promising antibacterial agents for biomedical applications.

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Preparation and characterization of chlorinated cross-linked chitosan/cotton knit for biomedical applications

Cited by 25 publications

References 24 publications

Antibacterial N-halamine fibrous materials

Antibacterial N-halamine fibrous materials

N-Halamine Hydantoin-Containing Chitosan: Synthesis, Characterization, Thermal and Photolytic Stability Studies

Novel N–Br Bond-Containing N-Halamine Nanofibers with Antibacterial Activities

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