Preparation and characterization of carboxymethyl chitosan sulfate/oxidized konjac glucomannan hydrogels

Recent Advances in Artificially Sulfated Polysaccharides for Applications in Cell Growth and Differentiation, Drug Delivery, and Tissue Engineering

“…Chitosan has some beneficial properties, such as excellent biocompatibility, antimicrobial activity, and nontoxicity, that promote its applications in many biomedical and pharmaceutical fields . After the sulfation of chitosan by using various sulfating agents, the total DSs of CHS and the distribution of the sulfate groups can be determined by combining elemental analysis and NMR spectroscopy . The total DSs of CHS can generally be determined by means of elemental analysis, whereas other quantification methods can be developed, such as the use of FT Raman spectroscopy .…”

“…CHS with diverse DS S and compositions can also be prepared through sulfating reactions under diverse conditions (Table ) . CHS is proven to be anticoagulant, antiviral, antimicrobial, and antioxidant .…”

“…CHS with diverse DS S and compositions can also be prepared through sulfating reactions under diverse conditions (Table ) . CHS is proven to be anticoagulant, antiviral, antimicrobial, and antioxidant . Therefore, it has attracted increasing interest in these fields, with the potential to replace native heparin and heparan sulfate .…”

“…[67][68][69][70] After the sulfation of chitosan by using various sulfating agents, the total DSs of CHS and the distribution of the sulfate groupsc an be determined by combininge lemental analysisa nd NMR spectroscopy. [71][72][73][74][75][76][77][78][79] The total DSs of CHS can generally be determinedb ym eans of elemental analysis, whereas other quantification methods can be developed, such as the use of FT Ramanspectroscopy. [71,77,79,80] GPC can be used to determine the molecular weights of CHS.…”

“…[70] The synthetic methods to control the distribution of sulfate groups wasreviewed in detail by Bedini et al [81] CHS with diverseD S S and compositions can also be prepared through sulfating reactions under diversec onditions (Table 3). [71][72][73][74][75][76][77][78][79][82][83][84][85] CHS is provent ob ea nticoagulant, antiviral, antimicrobial, and antioxidant. [69][70][71][72][73][74][75][76] Therefore, it has attracted increasing interest in these fields, with the potentialt or eplace native heparin and heparan sulfate.…”