Preparation and characterization of carbon nanofibrous/hydroxyapatite sheets for bone tissue engineering

El-Aziz, Asmaa M. Abd; Backly, Rania M. El; Taha, Nahla A.; El‐Maghraby, Azza; Kandil, Sherif

doi:10.1016/j.msec.2017.02.053

Cited by 36 publications

(24 citation statements)

References 23 publications

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“…HA is nontoxic and biodegradable and easily adsorbs onto surfaces of bioactive molecules. These characteristics make it useful for both tissue engineering (TE) and drug delivery applications [2, 7]. However due to the inherent brittle nature of hydroxyapatite nanoparticles, they are usually incorporated into polymeric nanocomposites to ensure easy processing [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Eggshell Based Nano-Engineered Hydroxyapatite and Poly(lactic) Acid Electrospun Fibers as Potential Tissue Scaffold

Apalangya

Rangari

Tiimob

et al. 2019

International Journal of Biomaterials

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Nanocomposite electrospun fibers were fabricated from poly(lactic) acid (PLA) and needle-like hydroxyapatite nanoparticles made from eggshells. The X-ray diffraction spectrum and the scanning electron micrograph showed that the hydroxyapatite particles are highly crystalline and are needle-liked in shape with diameters between 10 and 20 nm and lengths ranging from 100 to 200 nm. The microstructural, thermal, and mechanical properties of the electrospun fibers were characterized using scanning electron microscope (SEM), thermogravimetric analysis (TGA), dynamic scanning calorimetry (DSC), and tensile testing techniques. The SEM study showed that both pristine and PLA/EnHA fibers surfaces exhibited numerous pores and rough edges suitable for cell attachment. The presence of the rod-liked EnHA particles was found to increase thermal and mechanical properties of PLA fibers relative to pristine PLA fibers. The confocal optical images showed that osteoblast cells were found to attach on dense pristine PLA and PLA/HA-10 wt% fibers after 48 hours of incubation. The stained confocal optical images indicated the secretion of cytoplasmic extension linking adjoining nuclei after 96 hours of incubation. These findings showed that eggshell based nanohydroxyapatite and poly(lactic acid) fibers could be potential scaffold for tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Eggshell Based Nano-Engineered Hydroxyapatite and Poly(lactic) Acid Electrospun Fibers as Potential Tissue Scaffold

Apalangya

Rangari

Tiimob

et al. 2019

International Journal of Biomaterials

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“…However, the polymeric carbon-based material has the unique property of the tunable electrical conductivity [55]. The other advantage is that carbon is considered biocompatible with human body tissues [56]. Such advantages may allow the composite material as made in this work to have some potential applications in biomedical field.…”

Section: Hyperthermiamentioning

confidence: 99%

Electrohydrodynamic Casting Bismuth Telluride Microparticle-Loaded Carbon Nanofiber Composite Material With Multiple Sensing Functions

Gan

Chen

Gan

et al. 2017

Journal of Micro and Nano-Manufacturing

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In this work, an electrohydrodynamic casting approach was used to manufacture a carbon nanofiber (CNF) composite material containing bismuth telluride (Bi2Te3) particles. A 10% polyacrylonitrile (PAN) polymer solution was taken as the precursor to generate nanofibers. Bismuth telluride microparticles were added into the polymer solution. The particle-containing solution was electrohydrodynamically cast onto a substrate to form a PAN-based nanofiber composite mat. High temperature heat treatment on the polymeric matrix composite mat in hydrogen atmosphere resulted in the formation of a microparticle-loaded CNF composite material. Scanning electron microscopic (SEM) analysis was conducted to observe the morphology and reveal the composition of the composite material. Energy conversion functions in view of converting heat into electricity, electromagnetic wave energy into heat, and photon energy into electricity were shown. Strong Seebeck effect, hyperthermia, and photovoltaics of the composite mat were found. In addition, the potential applications as sensors were discussed.

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“…In vivo studies revealed soft fibrous tissue growth with no significant inflammatory response. Similarly, Abd El‐Aziz et al fabricated CNFs bioactive scaffolds functionalized by HAP and bovine serum albumin 83 . The scaffolds showed considerable biocompatibility with a minor inflammatory response.…”

Section: Biomedical Applications Of Cnfsmentioning

confidence: 99%

“…The majority of toxicity studies were devoted to assessing inhalation toxicity 121 . Remarkably, tissue engineering results suggest the relatively low toxicity of CNFs 83 . It is worth mentioning that there is difficulty in investigating the health effect of CNMs.…”

Section: Cnfs Challenges and Obstaclesmentioning

confidence: 99%

A comprehensive review summarizing the recent biomedical applications of functionalized carbon nanofibers

et al. 2021

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Since the discovery and fabrication of carbon nanofibers (CNFs) over a decade ago, scientists foster to discover novel myriad potential applications for this material in both biomedicine and industry. The unique economic viability, mechanical, electrical, optical, thermal, and structural properties of CNFs led to their rapid emergence. CNFs become an artificial intelligence platform for different uses, including a wide range of biomedical applications. Furthermore, CNFs have exceptionally large surface areas that make them flexible for tailoring and functionalization on demand. This review highlights the recent progress and achievements of CNFs in a wide range of biomedical fields, including cancer therapy, biosensing, tissue engineering, and wound dressing. Besides the synthetic techniques of CNFs, their potential toxicity and limitations, as biomaterials in real clinical settings, will be presented. This review discusses CNF's future investigations in other biomedical fields, including gene delivery and bioimaging and CNFs risk assessment.

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Preparation and characterization of carbon nanofibrous/hydroxyapatite sheets for bone tissue engineering

Cited by 36 publications

References 23 publications

Eggshell Based Nano-Engineered Hydroxyapatite and Poly(lactic) Acid Electrospun Fibers as Potential Tissue Scaffold

Eggshell Based Nano-Engineered Hydroxyapatite and Poly(lactic) Acid Electrospun Fibers as Potential Tissue Scaffold

Electrohydrodynamic Casting Bismuth Telluride Microparticle-Loaded Carbon Nanofiber Composite Material With Multiple Sensing Functions

A comprehensive review summarizing the recent biomedical applications of functionalized carbon nanofibers

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