Preparation and Characterization of a Novel Hybrid Hydrogel Composed of <i>Bombyx mori</i> Fibroin and Poly(<i>N</i>‐isopropylacrylamide)

Wang, Ting; Zhang, Linglei; He, Xiaojia

doi:10.1155/2013/832710

Cited by 4 publications

(4 citation statements)

References 48 publications

(52 reference statements)

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“… 20 SF solution after dialysis is metastable (predominance of silk I) and it can easily convert to a more stable form, by a conformational transition to silk II, forming stable hydrogels. SF gelation from aqueous solution is a kinetic process and depends on factors such as SF concentration, temperature, pH 21 and presence of other materials, such as poly( N -isopropylacrylamide) 22 and poly(ethylene oxide) polymers 23 . SF gelation process is also influenced by dialysis parameters, since the rate of salt removal will directly influence the conformational transition of SF.…”

Section: Introductionmentioning

confidence: 99%

The role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels

et al. 2014

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Silk fibroin has been widely explored for many biomedical applications, due to its biocompatibility and biodegradability. The aim of this work was to study the role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels. Hydrogels were prepared after 3 and 7 days of dialysis and the effect of freezing was analyzed. For that purpose, a part of the fibroin hydrogels underwent freezing at -20 °C for 24 h, followed by lyophilization and the rest of the hydrogels were kept at 8 °C for 24 h, with further lyophilization. The fibroin hydrogels were characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). Measurements by XRD and FTIR indicated that silk I and silk II structures were present in the fibroin hydrogels and that the secondary structure of fibroin is transformed mostly to β-sheet during the gelation process. Thermal analysis indicated that fibroin hydrogels are thermally stable with the degradation peak at around 330–340 °C. SEM micrographs showed porous structures and the fibroin hydrogels subjected to freezing presented a much larger pore size. Results indicate that the dialysis time and freezing did not alter the material crystallinity, conformation or thermal behavior; however, hydrogel microstructure was strongly affected by dialysis time and freezing, showing controlled pores size. This study provides fundamental knowledge on silk fibroin hydrogels preparation and properties and the studied hydrogels are promising to be used in the biomaterial field.

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Section: Introductionmentioning

confidence: 99%

The role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels

et al. 2014

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“…8–10 Among the most studied “intelligent” hydrogels, poly( N -isopropylacrylamide) (PNIPAAm) hydrogel had attracted considerable attentions due to its well-defined lower critical solution temperature (LCST) around 32–34℃, which was close to the human body temperature. 11,12 PNIPAAm is a typical thermoresponsive polymer, which undergoes rapid volume phase transition because of the repeated swelling–deswelling. 13,14 The inherent ability of PNIPAAm hydrogel to display dramatic changes in response to external stimuli renders it favorable for some biomedical applications such as drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment

Yuan

Shen

et al. 2013

J Biomater Appl

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In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.

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“…Many researchers have prepared copolymers containing PEG and PNIPAM as forms including grafting, diblock, triblock, multiblock, and star. [299][300][301][302] Solutions of PEG-PNIPAM copolymers exhibit adequate injection viscosities, high hydrogel strengths, and rapid gelation kinetics. PEG-PNIPAM copolymers form liquid solutions at ambient temperature and become relatively strong elastic hydrogels at body temperature that display unique micelle aggregation behavior in aqueous solutions.…”

Section: Peg and Poly(n-isopropylacrylamide)mentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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Preparation and Characterization of a Novel Hybrid Hydrogel Composed of Bombyx mori Fibroin and Poly(N‐isopropylacrylamide)

Cited by 4 publications

References 48 publications

The role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels

The role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels

Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

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