Preparation and characterization of a three-dimensional printed scaffold based on a functionalized polyester for bone tissue engineering applications

Seyednejad, Hajar; Gawlitta, Debby; Dhert, Wouter J.A.; Nostrum, Cornelus F. van; Vermonden, Tina; Hennink, Wim E.

doi:10.1016/j.actbio.2011.01.018

Cited by 121 publications

(82 citation statements)

References 36 publications

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“…30,31 Compared to PCL, pHMGCL showed increased degradation rates, improved cell adhesion and was shown to be 3D-printed with good shape fidelity. 32 Importantly, methacrylate groups can be introduced to allow covalent grafting of a hydrogel and thermoplastic after photopolymerization. 33 A synergistic effect on the mechanical properties of these hydrogel-thermoplastic constructs was found as a result of covalent grafting at the interface between the hydrogel and thermoplastic, which resulted in a remarkable stabilization and increased mechanical resistance against shear forces.…”

Section: Introductionmentioning

confidence: 99%

Biofabrication of reinforced 3D-scaffolds using two-component hydrogels

et al. 2015

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Biofabrication of reinforced 3D-scaff olds using two-component hydrogels Two strategies were developed to 3D print two-component hydrogels by exploiting polymers with thermogelling and chemoselective crosslinking properties. Pre-crosslinking by oxo-ester mediated native chemical ligation of the two components results in well-defi ned 3D printed constructs. Alternatively, mechanical reinforcement of these hydrogels through covalent cross-linking with a functionalized thermoplastic polymer can be achieved by the same chemoselective chemistry. Good cell compatibility was observed for hyaluronic acid containing scaff olds indicating their potential as new materials for biofabrication applications. precursors proceeded after extrusion to form mechanically stable hydrogels that exhibited a storage modulus of 9 kPa after 3 hours. Flow and elastic properties of the polymer solutions and hydrogels were analyzed under similar conditions to those used during the 3D-printing process. These experiments showed the ability to extrude the hydrogels, as well as their rapid recovery after applied shear forces. Hydrogels were printed in grid-like structures, hollow cones and a model representing a femoral condyle, with a porosity of 48 AE 2%. Furthermore, an N-hydroxysuccinimide functionalized thermoplastic poly-e-caprolactone (PCL) derivative was successfully synthesized and 3D-printed. We demonstrated that covalent grafting of the developed hydrogel to the thermoplastic reinforced network resulted in improved mechanical properties and yielded high construct integrity. Reinforced constructs also containing hyaluronic acid showed high cell viability of chondrocytes, underlining their potential for further use in regenerative medicine applications.

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Section: Introductionmentioning

confidence: 99%

Biofabrication of reinforced 3D-scaffolds using two-component hydrogels

et al. 2015

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“…Hajar Seyednejad et al [36] synthesized a novel copolyester, poly (hydroxyl methyl glycolide-co-e-caprolactone) (pHMGCL), for tissue engineering. It was shown that the cells filled the pores of the pHMGCL scaffold within seven days and displayed increased metabolic activity when compared with cells cultured in PCL scaffolds.…”

Section: Polyester Copolymersmentioning

confidence: 99%

“…1 readily prepared without protection and deprotection steps 2 excellent cell adhesion and growth 3 versatile and efficient surface modification 4 nontoxic and biocompatible cell and tissue scaffolds [35] PHMG-PCL 1 high metabolic activity of the cells 2 a compressive modulus in the range of the elastic modulus of bone 3 more than 70% porosity in the form of interconnected pores tissue engineering (bone regeneration) [36] poly(CL-co-DLLA) 1 adjustable degradation rate by the segment composition 2 the temperature dependency of degradation rate tissue engineering and drug delivery systems [37] PHBV-PLGA 1 high mechanical properties 2 good biodegradability and porosity 3 highly aligned, organized micro-architecture of each construct component nerve conduit for regeneration [38] PLGA-TPP 1 enhances the proliferation of cells seeded on it. [45] reported the synthesis of a novel block copolymers based on poly (N-Isopropylacrylamide) (PNIPAAm) block and a degradable poly (L-Lactide) (PLA) one with the purpose to assemble core-shell smart nanoparticles for narcotic antagonists' drug-delivery purpose.…”

Section: Polyester Copolymersmentioning

confidence: 99%

Emerging Perspectives in the Synthesis of Novel Degradable Biomedical Copolymers

Zhao¹,

Wang²,

Gao³

et al. 2015

Polymer-Plastics Technology and Engineering

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Biodegradable polymer is playing an increasingly significant role in the development of biomedical materials due to its good biocompatibility and biodegradability, and is undoubtedly the focus in the biomedical fields, such as controlled drug delivery, tissue engineering, and regenerative medicine. In this review, some new degradable biomedical copolymers reported over the past 5 years are introduced and discussed in combination with some our research results. The molecular design, chemical structures and related properties of these novel biodegradable copolymers are reported. In summarizing the review, the development, potential applications and future directions of the degradable biomedical copolymers are discussed.

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“…Whilst these could be manufactured using, for example, laser cutting methods common for stent production, a technology for the future is additive manufacturing (AM). Production and modification of metallic stents via AM has already been demonstrated and printable polymeric biomaterials for drug release and implants are becoming more widely available [60][61][62][63][64][65][66][67]. The workflow presented here has potential benefit not only for the personalised treatment of CVD; the scalability and freedom of design based AM offers a benefit for other intravascular applications.…”

Section: Med-15-1278mentioning

confidence: 99%