Preparation and Characterization of a Novel Natural Quercetin Self-Stabilizing Pickering Emulsion

Abstract

In contrast to their well-known physiological properties, phytochemicals, such as flavonoids, have been less frequently examined for their physiochemical properties (e.g., surface activity). A natural quercetin self-stabilizing Pickering emulsion was fabricated and characterized in the present study. The antisolvent precipitation method was used to modify quercetin (in dihydrate form), and the obtained particles were characterized by light microscope, atom force microscope, XRD, and contact angle. The antisolvent treatment was found to reduce the particle size, crystallinity, and surface hydrophobicity of quercetin. We then examined the effects of the antisolvent ratio, particle concentration, and oil fraction on the properties of the quercetin particle-stabilized emulsions. In addition, increasing the antisolvent ratio (1:1~1:10) effectively improved the emulsification performance of the quercetin particles. The emulsion showed good storage stability, and the particle size of the emulsion decreased with the rising particle concentration and increased with the rising oil phase ratio. The findings indicate that natural quercetin treated with antisolvent method has a good ability to stabilize Pickering emulsion, and this emulsion may have good prospective application potential for the development of novel and functional emulsion foods.

Intranasal Delivery of Carvedilol- and Quercetin-Encapsulated Cationic Nanoliposomes for Cardiovascular Targeting: Formulation and In Vitro and Ex Vivo Studies

“…Pure QC displayed prominent sharp crystalline peaks at 2θ angles of 6.19°, 9.4°, 10.84°, 12.5°, 13.72°, 14.26°, 15.82°, 16.84°, 17.92°, 20.92°, 23.88°, 24.4°, 26.6°, 27.34°, 28.42°, 30.52°, 31.82°, and 38.68°, which are similar to the XRD pattern of QC reported by Sun et al and Lu et al. at 2θ values of 10.9°, 13.58°, 16.52°, 18.04°, 21.8°, 26.08°, and 27.74° and 6.3–7.3°, 10.8°, 12.5°, 13.6–14.3°, 15.7–18.0°, 24.4°, and 27.3°. , These intense peaks indicate the crystalline structure in pure QC. P90H showed a broad XRD peak at a 2θ angle of 21.27° which is in accordance with the peak (21–22°) reported by Mangrulkar et al, revealing the amorphous nature of the lipid P90H.…”

“…Contact Angle Measurement. The wettability of a particle or the contact angle between the solid particle with the fluid (simulated nasal media) was determined following the technique reported by Liu et al 49 and Lu et al 50 with some modifications using the contact angle meter OCAH230 (Dataphysics, Germany) using the shape image analysis method. All the test formulations (CVD-NLPs, QC-NLPs, CVD/QC-NLPs, and blank NLPs) were air-dried forming a layer on the glass slide.…”

Progress of Drug Nanocrystal Self-Stabilized Pickering Emulsions: Construction, Characteristics In Vitro, and Fate In Vivo

“…When silybin nanocrystals reached 300 mg, the oil droplets were covered entirely by the nanocrystals, leading to a reduction in the emulsion droplet size and an enhancement in the stability of the DNSPE. The droplet size of a quercetin DNSPE also decreased as the nanocrystal concentration increased [ 40 ].…”

“…For example, the contact angle of native quercetin in air-water (120.65 • ) was significantly greater than that of quercetin nanocrystals. Specifically, the contact angle of nanocrystals ranging in size from 130 to 600 nm was reduced from 84.85 • to 65.15 • [40]. Considering that freeze drying may alter the surface properties of nanocrystals, some researchers recently produced a drug film about 100 µm thick by casting a nanosuspension directly into a Petri dish and drying it at room temperature.…”