Preparation and characterization of a novel once‐daily formulation of diltiazem using arabinogalactan as a channeling agent

Abstract

The aim of the present study was to develop a once-daily, delayed controlled release formulation for diltiazem. Developed formulation consists of two coated tablets inserted into a capsule; the first tablet is intended to produce a fast release profile, while the second tablet with a unique controlling membrane containing arabinogalactan as a channeling agent was designed to achieve a delayed controlled release profile for diltiazem. The in vitro characteristic of formulation was determined in terms of the surface morphology of the coated tablet, and the impact of the different polysaccharide in coating on the dissolution and in vitro drug release. Arabinogalactan was found to be most appropriate channeling agent to control in vitro drug release. When tested in buffer (pH 6.8) the formulation produced a desired delayed controlled release dissolution profile for over 24 h. Surface morphology of the coating film clearly demonstrated channeling formation on contact with the media. V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 126: E196-E202, 2012

Polysaccharide-Based Coatings as Drug Delivery Systems

“…Once it is enzymatically broken down, the porosity generated by arabinogalactan is ideal for controlled drug release. Due to its high water solubility, biocompatibility, and biodegradability, arabinogalactan shows potential as a drug carrier [ 109 ].…”

“…The formulation produced a desired delayed controlled release dissolution profile for over 24 h in buffer (pH 6.8). The surface morphology of the coating film showed channeling formation upon contact with the media [ 109 ].…”

“…Pharmaceutics 2023, 15, x FOR PEER REVIEW 19 of 42 release. Due to its high water solubility, biocompatibility, and biodegradability, arabinogalactan shows potential as a drug carrier [109].…”

Chitosan functionalization with a series of sulfur‐containing α‐amino acids for the development of drug‐binding abilities

“…In view of the rapidly growing interest in the research of Chi, its chemical modification was done because, in its native form, its solubility in most of aqueous or other biocompatible media is negligible because of embedded functional groups. The functionalization of Chi with S atom containing molecules (thiolation) and the immersion of sulfate groups (sulfation) were chosen in several chemical modifications, such as quaternization, sulfation, thiolation, alkylation, acylation, oligomerization, carboxyalkylation, hydroxyalkylation, phosphorylation, graft copolymerization, and enzymatic and other reactions because of specific applications in anticholesterol, 12,13 anticoagulant, [14][15][16] antitumor, 17 cardiovascular disease 4,18,19 and drug delivery. [2][3][4] These studies have been reported in a most scattered and piecemeal manner, and nothing can be generalized about a common principle with respect to the methodology of functionalization and the strength of the covalent bonds formed on functionalization.…”

Polysaccharides

“…4 and the alginate-chitosan hydrogels shown in Ref. 5) or tissue engineering (as in the dextran hydrogel scaffolds shown in Ref.…”