Preparation and characteristics of high-amylose corn starch/pectin blend microparticles: A technical note

Desai, Kashappa Goud H.

doi:10.1208/pt060230

Cited by 38 publications

(17 citation statements)

References 19 publications

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“…The diclofenac sodium has shown highly intense sharp peaks at ∼ 2θ of 6.6° (Desai, 2005); however, peaks due to diclofenac sodium crystals are not shown in the drug-loaded microspheres, confirming that the drug is molecularly dispersed in the microspheres.…”

Section: Xrdmentioning

confidence: 91%

Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation

Ray¹,

Banerjee²,

Maiti³

et al. 2010

Drug Delivery

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Section: Xrdmentioning

confidence: 91%

Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation

Ray¹,

Banerjee²,

Maiti³

et al. 2010

Drug Delivery

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“…Encapsulation of drugs into polymeric matrix can be achieved by techniques, such as emulsion, coacervation, spray drying, [10] etc. Among the several microencapsulation methods, spray drying technique is widely used in the pharmaceutical industries because it involves one-stage continuous process, yields reproducible results and can be applied for large-scale production [3][4][5][6]. Tableting of polymeric microparticles would result in controlled release of the drug.…”

Section: Introduction Bmentioning

confidence: 99%

“…In this regard, a previous article [6] describes the encapsulation of DS in HACS-pectin blend microparticles and their properties (size, encapsulation efficiency, surface morphology, and drug release behavior). This article mainly focuses on the tableting of DS-loaded HACS-pectin blend microparticles thus prepared and the characteristics of tableted microparticles.…”

Section: Introduction Bmentioning

confidence: 99%

Properties of Tableted High-Amylose Corn Starch–Pectin Blend Microparticles Intended for Controlled Delivery of Diclofenac Sodium

Desai

2007

J Biomater Appl

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This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microencapsulation technique in the pharmaceutical industry. The mean particle size of various formulations of blend microparticles is in the range of 5.8-7.3 mm. Fourier transform infrared (FTIR) spectroscopy study reveals the absence of well-defined interaction between HACS-pectin and polymers-DS. The blend microparticles thus prepared were compressed into tablets using the directly compressible excipients. A cross-sectional view of the tablet reveals the presence of nearly spherical shaped particles in the tablet, suggesting that the system chosen is ideal for tableting. In vitro drug release study indicates that tableted microparticulate system is found to be suitable for the manipulation of release behavior for DS in the gastrointestinal tract. Release mechanism of the DS from tableted microparticles is by Fickian diffusion since the value of n approaches 0.5.

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“…For the Korsmeyer-Peppas model, the fraction of drug remaining at time t was determined for every time interval log (M t /M ∞ ) and plotted against the log of time t. The slope of the line was taken as the value of n. 22 …”

mentioning

confidence: 99%

Formulation and development of floating capsules of celecoxib: In vitro and in vivo evaluation

et al. 2007

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The objective of the present study was to develop a hydrodynamically balanced system for celecoxib as single-unit floating capsules. Various grades of low-density polymers were used for formulation of these capsules. The capsules were prepared by physical blending of celecoxib and the polymer in varying ratios. The formulation was optimized on the basis of in vitro buoyancy and in vitro release in citrate phosphate buffer pH 3.0 (with 1% sodium lauryl sulfate). Capsules prepared with polyethylene oxide 60K and Eudragit RL100 gave the best in vitro percentage release and were used as the optimized formulation. By fitting the data into zero-order, first-order, and Higuchi models, we concluded that the release followed zero-order kinetics, as the correlation coefficient (R value) was higher for zero-order release. For gamma scintigraphy studies, celecoxib was radiolabeled with technetium-99m by the stannous reduction method. To achieve the maximum labeling efficiency the process was optimized by studying the reaction at various pH conditions and stannous concentration levels. The radiolabeled complex was added to the optimized capsule, and dissolution studies were performed to ensure that there was no leaching of radioactivity from the capsules. Gamma imaging was performed in rabbits to assess the buoyancy of the optimized formulation. The optimized formulation remained buoyant during 5 hours of gamma scintigraphic studies in rabbits.

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Preparation and characteristics of high-amylose corn starch/pectin blend microparticles: A technical note

Cited by 38 publications

References 19 publications

Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation

Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation

Properties of Tableted High-Amylose Corn Starch–Pectin Blend Microparticles Intended for Controlled Delivery of Diclofenac Sodium

Formulation and development of floating capsules of celecoxib: In vitro and in vivo evaluation

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