Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation

Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application

“…Earlier, we have developed the poly(vinyl alcohol) based IPN system for oral controlled release application [10,11]. So as a part of our ongoing research work on the application of hydrophillic biopolymers, the present work describes the development and evaluation of IPN hydrogel microspheres composed of NaCMC and PVA to encapsulate diclofenac sodium (DS), a model drug with a shorter biological half-life of 1-2 h. The microspheres prepared have been characterized by different techniques to understand their various physicochemical behavior and in vitro drug release characteristics.…”

A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application

“…It can be drawn a conclusion that the formation of hydrogen bonds between two different macromolecules competes with the formation of hydrogen bonds between molecules of the same polymer (Sionkowska, 2003). Moreover, the characteristic peaks of MH (Figure 2b) disappeared in the MH/PVA/SA physical mixture and MH/ PVA/SA NFM, indicating the amorphous dispersion of MH into the SA/PVA matrix (Ray et al, 2010). And the melting temperatures of the polymers employed in MH-loaded nanofibers were not obviously influenced by the procedure (Figure 2a).…”

Designing hydrogel particles for controlled or targeted release of lipophilic bioactive agents in the gastrointestinal tract

“…For example, they may be designed to breakdown and release their cargo within the mouth, stomach, small intestine, or colon by careful selection of the biopolymer building blocks and the forces holding them together [10][11][12].…”