Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic

Wu, Chengtie; Chang, Jiang; Wang, Junying; Ni, Siyu; Zhai, Wentao

doi:10.1016/j.biomaterials.2004.09.019

Cited by 208 publications

(123 citation statements)

References 18 publications

Supporting

Mentioning

114

Contrasting

Order By: Relevance

“…27 Previously it has been showed that low Ca and Si ions concentrations released from bioactive akermanite (Ca 2 MgSi 2 O 7 ) and bredigite (Ca 7 MgSi 4 O 16 ) promoted osteoblast and fibroblast proliferation while their high ionic concentrations inhibited cell proliferation. 7,8 The newly developed CaTiSiO 5 possess a higher chemical stability and release less Ca and Si ionic products compared with CaSiO 3 ceramics. In agreement with previously published studies, 7,8 our results suggest that lower concentration of Ca and Si ionic products may play a significant role in stimulating HBDC proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The stimulatory effect of the Ca and Si containing ionic products released from materials on osteoblast proliferation, differentiation, gene expression, and mineralization have been documented. [4][5][6][7][8] CaSiO 3 is a typical CaÀ ÀSi based bioceramic, regarded as a potential bioactive material for bone tissue regeneration and implant coating due to their bioactivity. 9,10 However, a major drawback of the CaSiO 3 ceramics is their high dissolution rate leading to a high pH value in the surrounding environment, 11,12 which is detrimental to the cells.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incorporation of titanium into calcium silicate improved their chemical stability and biological properties

Ramaswamy

Soeparto

et al. 2007

J Biomedical Materials Res

Self Cite

108

View full text Add to dashboard Cite

Calcium silicate (CaSiO(3)) is regarded as a potential bioactive material. However, its poor chemical stability and cytocompatibility limits its biological applications. The aim of this study is to incorporate Titanium (Ti) into CaSiO(3) to produce a ceramic with improved chemical stability and biological properties. Sphene (CaTiSiO(5)) ceramics were prepared by sintering sol-gel-derived CaTiSiO(5) powder compacts and their chemical stability was assessed by measuring the ions released and weight loss after soaking CaTiSiO(5) in simulating body fluid for 1, 3, 7, and 14 days. Results indicated that CaTiSiO(5) has a significantly improved chemical stability, compared with CaSiO(3). The ability of CaTiSiO(5) ceramics to support human bone-derived cells (HBDC) attachment, proliferation, and differentiation was assessed using scanning electron microscopy, MTS, and alkaline phosphatase activity assays, respectively. CaTiSiO(5) ceramics supported HBDC attachment and significantly enhanced their proliferation and differentiation, compared with CaSiO(3) ceramics. Taken together, this study demonstrates that the newly developed CaTiSiO(5) ceramics possess excellent chemical stability and bioactivity, suggesting their potential use in skeletal tissue regeneration and as coating onto currently available orthopedic/dental implants.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporation of titanium into calcium silicate improved their chemical stability and biological properties

Ramaswamy

Soeparto

et al. 2007

J Biomedical Materials Res

Self Cite

108

View full text Add to dashboard Cite

show abstract

“…More importantly, it obviously stimulated more proliferation and osteogenic differentiation of osteoblasts, bone marrow stromal cells (BMSCs) and adipose-derived stem cells (ADSCs) as compared to β-TCP (Wu et al, 2005;Sun et al, 2006;Liu et al, 2008). All these preliminary studies indicated that akermanite bioceramic might serve as a suitable biomaterial for bone regeneration.…”

Section: Xia Et Al Proliferation and Osteogenic Differentiation Ofmentioning

confidence: 99%

Proliferation and osteogenic differentiation of human periodontal ligament cells on akermanite and β-TCP bioceramics

Xia

Zhang²,

Chen³

et al. 2011

eCM

View full text Add to dashboard Cite

The purpose of this study was to investigate the effects of akermanite as compared to β-TCP on attachment, proliferation, and osteogenic differentiation of human periodontal ligament cells (hPDLCs). Scanning electron microscopy (SEM) and actin filament labeling were used to reveal attachment and growth of hPDLCs seeded on β-TCP and akermanite ceramic. Cell proliferation was tested by lactic acid production and MTT analysis, while osteogenic differentiation was assayed by alkaline phosphatase (ALP) expression and real-time polymerase chain reaction (PCR) analysis on markers of osteopontin (OPN), dentin matrix acidic phosphoprotein-1 (DMP-1), and osteocalcin (OCN), and further detected by enzymelinked immunosorbent analysis (ELISA) analysis for OCN expression. Besides, the ions released from akermanite and their effect on hPDLCs was also measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES), MTT analysis, ALP expression and real-time PCR analysis. hPDLCs attached well on both ceramics, but showed better spreading on akermanite. hPDLCs proliferated more rapidly on akermanite than β-TCP. Importantly, osteogenic differentiation of hPDLCs was enhanced on akermanite compared to β-TCP. Besides, Ca, Mg and Si ions were released from akermanite, while only Ca ions were released from β-TCP. Moreover, more pronounced proliferation and higher osteogenic gene expression for hPDLCs cultured with akermanite extract were detected as compared to cells cultured on akermanite. Therefore, akermanite ceramic showed an enhanced effect on proliferation and osteogenic differentiation of hPDLCs, which might be attributed to the release of ions containing Ca, Mg and Si from the material. It is suggested that akermanite ceramics may serve as a potential material for periodontal bone regeneration.

show abstract

“…As reported recently, some single composition in CaO-MgO-SiO 2 system like akermanite (Ca 2 MgSi 2 O 7 ), bredigite (Ca 7 MgSi 4 O 16 ), merwinite [42] and monticellite [43,44] ceramic phases [42][43][44][45][46][47] do not only possess an improved mechanical strength when compared with hydroxyapatite and wollastonite ceramics, but also were degradable and revealed bone-like apatite formation ability in SBF. In addition, the ionic products from akermanite and bredigite could stimulate cell proliferation [46,47]. Based on our results, the composite phases in this system gave different forms of HA crystals including the best form of HA (Cauliflower).…”

Section: In-vitro Bioactivity Of the Batchesmentioning

confidence: 58%

Bioactivity Investigations with Calcia Magnesia Based Composites

Ewais¹,

Moustafa²,

Pardun³

et al. 2015

JMSE-A

View full text Add to dashboard Cite

Abstract:The bioactivity and physico-mechanical properties of calcia magnesia based composites developed in this study were investigated. Different composite mixtures containing calcia-magnesia have been processed with the addition of alumina, silica or zircon. These system powders were formed and fired at two different temperatures. The produced composites were characterized by means of X-ray diffraction, SEM (scanning electron microscope) equipped with EDS (energy dispersive X-ray spectrometry), density and apparent porosity measurements, mechanical testing and in-vitro evaluation in a SBF (simulated body fluid) solution. The compositions termed "I", "II" and "III" gave clear tendency towards the formation-ability of HA (hydroxyapatite). Composite "1" gave cubic and spindle HA crystallite, while composites "II" and "III" fired at 1,300 and 1,400 °C formed typically "cauliflower" morphology and their evaluated physico-mechanical properties are similar to the properties of human cortical bone. Thus, composites "II" and "III" might be a promising bone implant materials. Beside the bioactivitiy of composite "I", it also contains highly CA (cementing phase) and MA (bioinert) phases, therefore, it might be nominated as a promising bioceramic material especially for different purposes such as scaffold, bone replacement, bone repair and coating.

show abstract

Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic

Cited by 208 publications

References 18 publications

Incorporation of titanium into calcium silicate improved their chemical stability and biological properties

Incorporation of titanium into calcium silicate improved their chemical stability and biological properties

Proliferation and osteogenic differentiation of human periodontal ligament cells on akermanite and β-TCP bioceramics

Bioactivity Investigations with Calcia Magnesia Based Composites

Contact Info

Product

Resources

About