Preparation and characterisation of ibuprofen–poloxamer 188 granules obtained by melt granulation

Passerini, Nadia; Albertini, Beatrice; González-Rodrı́guez, Marı́a Luisa; Cavallari, Cristina; Rodriguez, Lorenzo

doi:10.1016/s0928-0987(01)00210-x

Cited by 171 publications

(135 citation statements)

References 11 publications

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“…Poor water solubility and slow dissolution are often the main reasons for the rejection of potentially active drugs [10,11]. Several approaches have been employed to overcome this problem, such as the preparation of solid dispersions of an active agent in a biologically inert matrix [12][13][14], drug dissolution in the presence of polymeric micelles in the dissolution medium [15], addition of surfactants [15][16][17][18], micronization-particle size reduction to nano-or microsize [19][20][21], melt granulation technique [22,23] and formation of eutectics [24,25], including drug-polymer component systems [26,27].…”

Section: Introductionmentioning

confidence: 99%

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Gòrniak

Wojakowska

Karolewicz

et al. 2010

J Therm Anal Calorim

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Enhancement of the dissolution rate of poorly soluble compounds through the formation of drug-drug eutectics was investigated using fenofibrate and acetylsalicylic acid. Solid-liquid equilibria in the system under study were investigated by differential scanning calorimetry (DSC). The phase diagram for the whole range of compositions was constructed. In addition, existence of a metastable polymorph of fenofibrate has been confirmed. The investigation has revealed that acetylsalicylic acid and fenofibrate form a simple eutectic mixture containing 0.958 mol fraction of fenofibrate at the eutectic point. Dissolution rate improvement of fenofibrate correlated with the phase diagram. The amount of fenofibrate released from the solid dispersions that contained fenofibrate as the eutectic mixture with acetylsalicylic acid was at least threefold higher compared to untreated fenofibrate.

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Section: Introductionmentioning

confidence: 99%

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Gòrniak

Wojakowska

Karolewicz

et al. 2010

J Therm Anal Calorim

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“…(7) where, K is the constant reflecting the design variables of the system. Q 0 1/3 -Qt 1/3 = K HC t … … ……………….. (8) where, Q t is the amount of drug released in time t, Q 0 is the initial amount of the drug in tablet and K HC is the rate constant for HixsonCrowell rate equation.…”

Section: Kinetic Analysis Of Drug Release Datamentioning

confidence: 99%

“…In formulating wax matrix systems, different processing methods, such as dry blending, wet granulation, melt granulation and extrusion spheronization, have been used [8][9]. Melt granulation method can be used for granulating water sensitive material and producing sustained release granulations.…”

Section: Introductionmentioning

confidence: 99%

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Nanjwade¹,

Mhase²,

Manvi³

2011

Trop. J. Pharm Res

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“…sustained release microspheres formulation of glipizide and metformin HCl that can overcome all the limitations of both the drugs and for that microspheres of those drugs is prepared by using various polymer by solvent evaporation technique not only avoid the contact between both of drugs but also increases the solubility profile as well as bioavailability. [5] Most importantly, because of prolonged duration of action, It will produce a strict control of blood pressure and consequently less hypertension complication. The combination of metformin HCl with glipizide is more effective than individual therapy because of the synergism.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Ethyl Cellulose, Eudragit Rspo and Eudragit Rlpo Loaded Microspheres With Metformin and Glipizide: In Vitro and in Vivo Studies

Dewan¹

2017

WJPR

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Objective:The aim of the current exploration is to formulate and evaluate the metformin and glipizide, both are type II anti-diabetic agents, loaded microspheres with an objective to sustained release as well as improve bioavailability. Materials and method: Microspheres were prepared by solvent evaporation method using different rate retardant polymers including eudragit RSPO, eudragit RLPO and ethyl cellulose. Prepared microspheres were characterized by percent drug loading and drug entrapment efficiency, FTIR, DSC and SEM. UVSpectrophotometric method was applied to assay the microspheres and in vitro dissolution studies according to USP paddle method were carried out in phosphate buffer (pH 6.8) for 8 hours. Results: The in vitro release kinetics was studied in different mathematical release models. The best data fitted with the highest correlation coefficient (R 2 ) for microspheres was obtained for Korsmeyer-Peppas model.

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Preparation and characterisation of ibuprofen–poloxamer 188 granules obtained by melt granulation

Cited by 171 publications

References 11 publications

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Formulation and Characterization of Ethyl Cellulose, Eudragit Rspo and Eudragit Rlpo Loaded Microspheres With Metformin and Glipizide: In Vitro and in Vivo Studies

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