Preparation and Biological Evaluation of Novel Pyrimidines from Novel Chalcones

Jyothi, M.; Venkatesh, P.

doi:10.13005/ojc/280346

Cited by 6 publications

(3 citation statements)

References 2 publications

(3 reference statements)

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“…Jyothi M V et al 37 synthesized pyrazolines (2j) and studied for their anti-inflammatory activity. Compounds possess some degree of antiinflammatory activity and were free from toxicity Khalil et al 38 inferred the compound (2k) of 3, 5-Diaryl-2-Pyrazoline Derivatives as most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.…”

Section: P Vaidya Et Almentioning

confidence: 99%

Untitled

2015

IJPSR

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Section: P Vaidya Et Almentioning

confidence: 99%

Untitled

2015

IJPSR

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“…[98,99] Besides, various conditions have been employed during the synthesis of pyrimidine (i.e., microwave, [100][101][102] ultrasonic-MW, [103] ultrasonic irradiations. [104][105][106] conventional way via reflux, [107][108][109] phase transfer, [110] stirring. [111] in basic/acidic media (i.e., conc.…”

Section: Introductionmentioning

confidence: 99%

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

Farooq

Ngaini

2021

Journal of Heterocyclic Chem

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Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.

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“…A reação então foi colocada em banho de gelo e acidificada com HCl, 1M. O sólido obtido foi coletado e purificado via recristalização em diclorometano à temperatura reduzida (geladeira) 57.…”

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Síntese, caracterização e estudo fotofísico de chalconas fluorescentes

Melo¹

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The search for compounds having luminescent activity (fluorescence) have extreme importance because high sensitivity detection of these in analytical techniques. However, the technique of molecular fluorescence spectroscopy is not widely used due to the limited number of chemical systems which operate with considerable luminescent activity. In this perspective were synthesized and evaluated eleven chalcones structures, starting from the 4-(dimethylamino)benzaldehyde and 3,4,5-trimethoxybenzaldehyde, as well discussed in the literature to be a chromophore and for the biological activity, respectively. The compounds were characterized and have their structures determined by X-ray diffraction, when possible. Their photophysical properties and solvatochromic behaviors were investigated. Noted the broad spectrum of compounds class performance were also evaluated molecular docking studies and in vitro tests were conducted to Chagas disease, by WHO recognized as neglected. Searching for better possibility in technological application were produced microfibers with the polyvinylpyrrolidone polymer and these were characterized for SEM analysis.

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Preparation and Biological Evaluation of Novel Pyrimidines from Novel Chalcones

Cited by 6 publications

References 2 publications

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One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

Síntese, caracterização e estudo fotofísico de chalconas fluorescentes

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