Preparation and biodistribution of [111In]-rHuEpo for erythropoietin receptor imaging

Sadeghpour, Hossein; Jalilian, Amir Reza; Akhlaghi, Mehdi; Kamali-Dehghan, Mohsen; Mirzaii, M.; Shafiee, A.

doi:10.1007/s10967-007-7212-1

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Production and Quality Control Of 111 In-incl 3 Solution2

Introduction2

Diagnostic Radiopharmaceuticals Single Photon Emission Compu1

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2023

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Cited by 15 publications

(19 citation statements)

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“…[5] Indium-111 chloride was prepared by 22 MeV proton bombardment of the enriched cadmium-112 target at a 30 MeV cyclotron, with a current of 100 µA for 48 min (80 µAh). After the dissolution of the irradiated target by conc.…”

Section: Production and Quality Control Of 111 In-incl 3 Solutionmentioning

confidence: 99%

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials

et al. 2014

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Section: Production and Quality Control Of 111 In-incl 3 Solutionmentioning

confidence: 99%

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials

et al. 2014

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“…Tc-UBI Production. Ubiquicidin (UBI) [29][30][31][32][33][34][35][36][37][38][39][40][41] (TGRAKRRMQYNRR, 1693 Da) is a synthetic cationic chemotactic peptide that preferentially binds to bacterial cell membrane at the site of infection with high sensitivity and specificity. The radioactive peptide was totally synthesized and formulated by the investigators in the country.…”

Section: Diagnostic Radiopharmaceuticals Single Photon Emission Compumentioning

confidence: 99%

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

Jalilian

Beiki

Hassanzadeh-Rad

et al. 2016

Seminars in Nuclear Medicine

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“…Cadmium electroplating over a copper surface was performed according to previously reported method [18]. 111 In-indium chloride was prepared by 20 MeV proton bombardment of the natural Cd target [13].…”

Section: Production and Quality Control Of 111 In-incl 3 Solutionmentioning

confidence: 99%

Preparation, Quality Control and Biodistribution Studies of two [111In]-Rituximab Immunoconjugates

Jalilian¹

2008

Sci Pharm

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In order to use Auger-electron therapeutic effects in CD20 antigen targeting in lymphomas, Mabthera™ (rituximab) N-succinimidyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA-NHS) and ccDTPA separately. Conjugated-Rituximab was obtained by the addition of 1 ml of a rituximab pharmaceutical solution (5 mg/ml, in phosphate buffer, pH=7.8) to a glass tube pre-coated with freshly prepared DOTA-NHS or ccDTPA (0.01-0.1 mg) at 25°C. Radiolabeling was performed at 37°C in 3hand room temperature for one hour for DOTA-conjugate and DTPA-conjugate respectively. HPLC showed an overall radiochemical purity of 97.5 and 95% for DOTA and DTPA-conjugates respectively (Specific activity =2800-5600 GBq/mM). The final isotonic 111In-rituximab complexes were checked by gel electrophoresis for radiolysis. Preliminary biodistribution studies in normal rat model performed to determine radioimmunoconjugates distribution of up to 48h.

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Preparation and biodistribution of [111In]-rHuEpo for erythropoietin receptor imaging

Cited by 15 publications

References 23 publications

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

Preparation, Quality Control and Biodistribution Studies of two [111In]-Rituximab Immunoconjugates

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Preparation and biodistribution of [111In]-rHuEpo for erythropoietin receptor imaging

Cited by 15 publications

References 23 publications

Preclinical evaluation of [ 111 In]-DOTA-trastuzumab for clinical trials

Preclinical evaluation of [ 111 In]-DOTA-trastuzumab for clinical trials

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

Preparation, Quality Control and Biodistribution Studies of two [111In]-Rituximab Immunoconjugates

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Product

Resources

About

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials

Preclinical evaluation of [ ¹¹¹ In]-DOTA-trastuzumab for clinical trials