Preparation and Biocompatibility of Poly Methyl Methacrylate (PMMA)-Mesoporous Bioactive Glass (MBG) Composite Scaffolds

Abstract

In recent years, the rising number of bone diseases which affect millions of people worldwide has led to an increased demand for materials with restoring and augmentation properties that can be used in therapies for bone pathologies. In this work, PMMA- MBG composite scaffolds containing ceria (0, 1, 3 mol%) were obtained by the phase separation method. The obtained composite scaffolds were characterized by X-ray diffraction, infrared spectroscopy, and scanning electron microscopy. UV–Vis measurement and EDX analysis confirmed the presence of cerium ions in the composite scaffolds. Evaluation of the in-vitro biocompatibility using MTT assay showed that composite scaffold containing 1 mol% of ceria presented higher viability than control cells (100%) for concentrations ranging between 5 and 50% after 96 h of incubation.

Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass

“…The developing of load-bearing scaffolds with high porosity is another of the major purposes of bone tissue engineering. However, the highly porous structure is obtained at the expense of mechanical strength (Ma and Choi 2001 ; Atkinson et al 2021 ). In this trade-off, the highly porous structure is preferred in tissue engineering applications.…”

Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

“…The obtained mixtures were transferred into removable molds and kept for 7 days at room temperature. Afterwards, the as-prepared scaffolds were removed from the molds and thermally treated at 600 • C, according to DTA results [25], with a heating rate of 1 • /min and 2h plateau at maximum temperature to remove the PMMA template, Pluronic P123, and the nitrates. Scaffolds with a diameter of 10 mm and a height of 5 mm were obtained.…”

“…As can be observed, the absorption bands of Ce 4+ and Ce 3+ are overlapped and the contribution of each of them requires them to be clearly separated in the absorption spectrum. In addition, the contribution of PMMA in the scaffolds and especially the PMMA particles dispersion within the scaffolds, which may lead to changes in the scaffolds morphology as the cerium composition increases, is considered [25]. In this context, for the structure of the absorption band of Ce 4+ and Ce 3+ , the absorption spectrum of each sample was deconvoluted into Gaussian functions in order to clearly separate the contribution of Ce 4+ from the one of Ce 3+ , Figure 1b,c.…”

Special Issue: Bioceramics, Bioglasses, and Gels for Tissue Engineering

“…This Special Issue collection of articles represents the keen and diverse research ensuing toward innovative functionalities and technologies in the biomedical sector. Atkinson I et al [29] fabricated composite scaffolds consisting of poly methyl methacrylate (PMMA) Ceriumdoped mesoporous bioactive glass (MBG), by means of the phase separation method. In addition, they studied the effect of ceria addition and thereby the property changes, particularly the crystallization behavior, of the SiO 2 -CaO-P 2 O 5 -CeO 2 system [30].…”