Preparation and application of pH-responsive drug delivery systems

Ding, Haitao; Tan, Ping; Fu, Shiqin; Tian, Xiaohe; Zhang, Hu; Ma, Xuelei; Gu, Zhongwei; Luo, Kui

doi:10.1016/j.jconrel.2022.05.056

Cited by 158 publications

(89 citation statements)

References 339 publications

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“…2(d)). Besides, the bright cyan fluorescence of GP5*Pro-ANI in the solid state further demonstrated its AIE properties, which corresponded to Scheme 1 A schematic overview of the construction of a supramolecular nano-delivery system based on the PARP inhibitor prodrug and pillar [5]arene and the application for drug-resistance therapy. the emission state of GP5*Pro-ANI in its aggregation state in water (Fig.…”

mentioning

confidence: 75%

“…To sum up, we successfully constructed a novel supramolecular nano-delivery system (GP5*Pro-ANI) based on the host-guest interaction between glycosylated pillar [5]arene (GP5) and AIE PARP inhibitor prodrug (Pro-ANI). The obtained system could self-assemble into nanovesicles with a high DOX loading rate.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

mentioning

confidence: 99%

“…1 Prodrugs modified by peculiar chemical bonding with enhanced water solubility, target ability, and stimuli-responsive ability have been provided to solve these problems. 4,5 However, the traditional single-drug prodrugs are characterized by poor biocompatibility, low accumulation, and difficult synthesis. 6 A supramolecular nano-delivery system constructed by selfassembling a supramolecular nanoprodrug through non-covalently binding host-guest complexation could effectively improve the drug delivery efficiency and avoid multi-step synthesis, leading to stronger cell permeability and EPR effect, and could also be used to overcome drug resistance by the co-medication strategy.…”

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confidence: 99%

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A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

Yang

Gao

et al. 2022

Chem. Commun.

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confidence: 75%

Section: Conflicts Of Interestmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

Yang

Gao

et al. 2022

Chem. Commun.

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“…The shrinkage of cationic hydrogel occurs when pH is higher than pKa [ 113 ]. In order to achieve a precise medication release, the hydrogel’s swelling behavior may thus be modified by the pH of the tumor microenvironment [ 114 ]. Covalent bonds that are sensitive to pH, such as ketals and hydra-zone bonds, are present in another pH-responsive hydrogel [ 115 , 116 , 117 ].…”

Section: The Common Types Of Smart Hydrogelsmentioning

confidence: 99%

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Zhao

Ran

Xie

et al. 2022

Gels

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At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow suppression, malfunction of the liver and kidneys, and neurotoxicity. As a new local drug delivery system, the smart drug delivery system based on hydrogel can control drug release in time and space, and effectively alleviate or avoid these problems. Environmentally responsive hydrogels for smart drug delivery could be triggered by temperature, photoelectricity, enzyme, and pH. An overview of the most recent research on smart hydrogels and their controlled-release drug delivery systems for the treatment of oral cancer is given in this review. It is anticipated that the local drug release method and environment-responsive benefits of smart hydrogels will offer a novel technique for the low-toxicity and highly effective treatment of oral malignancy.

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Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

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Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

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Preparation and application of pH-responsive drug delivery systems

Cited by 158 publications

References 339 publications

A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

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