A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

Yang, Manman; Yang, Ke; Gao, Bingling; Wang, Peng; Li, Tianjiao; Zheng, Yi; Pei, Yuxin; Pei, Zhichao; Lv, Yinghua

doi:10.1039/d2cc04238j

Cited by 10 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each role of the off-the-shelf building block in the displacement assays contributed to obtaining fingerprint-like response profiles for pattern recognition in real samples. Recently, the potential of chemosensors in practical sensing applications has been reported; [14,[120][121][122][123][124][125][126][127][128] however, their favorable sensing performance still relies on complicated molecular designs that require multiple steps of organic synthesis. In other words, the detectable analyte structures are limited by the structure of building blocks of chemosensors.…”

Section: Discussionmentioning

confidence: 99%

Methodologies for Spontaneous Preparation of Chemosensors and Their Arrays Using Off‐the‐Shelf Reagents

Sasaki,

Minami

2023

ChemNanoMat

View full text Add to dashboard Cite

Chemosensors are promising candidates to visualize molecular recognition information through colorimetric or fluorescence responses. In chemosensor designs, the following requirements should be considered; 1) molecular geometries with analytes, 2) mechanisms to cause optical changes upon analyte capture, and 3) solubility for sensing applications. On the other hand, the designs and realization of chemosensors covering the abovementioned requirements are still at the frontiers. In the conventional strategy, molecular geometries between receptors and analytes have been mainly considered. However, this approach confronts issues of synthetic efforts to obtain elaborate designs of chemosensors, which leads to a decrease in the water solubility of chemosensors derived from the complicated and aromatic molecular structures. Herein, this Review summarizes methodologies for self‐assembled chemosensors only using off‐the‐shelf reagents to easily obtain various chemosensors without organic synthesis. The concept of self‐assembled chemosensors comprising off‐the‐shelf reagents with water‐solubility realizes not only the easy tuning of optical sensing properties but also chemical sensing in real samples. Through the comprehensive sensing applications using the facile self‐assembled chemosensors and their arrays, the usability of off‐the‐shelf reagents in analytical chemistry will be clarified.

show abstract

Section: Discussionmentioning

confidence: 99%

Methodologies for Spontaneous Preparation of Chemosensors and Their Arrays Using Off‐the‐Shelf Reagents

Sasaki,

Minami

2023

ChemNanoMat

View full text Add to dashboard Cite

show abstract

“…Figure 2C illustrates that the red fluorescence was much lower in DOX-BSA/MnO 2 NP-treated cells contrasted with the free-DOX-treated cells, indicating the cell internalization of DOX-BSA/ MnO 2 NPs was significantly slower than free DOX, which may be because of the difference between DOX-BSA/MnO 2 NPs endocytosis along with DOX passive diffusion mechanism and different DOX release rate of DOX together DOX-BSA/MnO 2 NPs (Wallat et al, 2018;Zhang et al, 2021). DOX acts mainly by entering the nucleus and causing DNA damage (Yang et al, 2022). The DOX fluorescence was mainly accumulated in MCF-7 cell nuclei following incubation with free DOX along with DOX-BSA/ MnO 2 NPs.…”

Section: In Vitro Cellular Uptake Investigationmentioning

confidence: 94%

Hypoxia-ameliorated photothermal manganese dioxide nanoplatform for reversing doxorubicin resistance

et al. 2023

View full text Add to dashboard Cite

Drug resistance is a huge hurdle in tumor therapy. Tumor hypoxia contributes to chemotherapy resistance by inducing the hypoxia-inducible factor-1α (HIF-1α) pathway. To reduce tumor hypoxia, novel approaches have been devised, providing significant importance to reverse therapeutic resistance and improve the effectiveness of antitumor therapies. Herein, the nanosystem of bovine serum albumin (BSA)-templated manganese dioxide (MnO2) nanoparticles (BSA/MnO2 NPs) loaded with doxorubicin (DOX) (DOX-BSA/MnO2 NPs) developed in our previous report was further explored for their physicochemical properties and capacity to reverse DOX resistance because of their excellent photothermal and tumor microenvironment (TME) response effects. The DOX-BSA/MnO2 NPs showed good biocompatibility and hemocompatibility. Meanwhile, DOX-BSA/MnO2 NPs could greatly affect DOX pharmacokinetic properties, with prolonged circulation time and reduced cardiotoxicity, besides enhancing accumulation at tumor sites. DOX-BSA/MnO2 NPs can interact with H2O2 and H+ in TME to form oxygen and exhibit excellent photothermal effect to further alleviate hypoxia due to MnO2, reversing DOX resistance by down-regulating HIF-1α expression and significantly improving the antitumor efficiency in DOX-resistant human breast carcinoma cell line (MCF-7/ADR) tumor model. The hypoxia-ameliorated photothermal MnO2 platform is a promising strategy for revering DOX resistance.

show abstract

“…[1][2][3] Overexpressed drug efflux transporters, DNA damage repair, drug inactivation, target mutation, and apoptosis disorders lead to tumor resistance. [3][4][5] The latest research shows that ion channels contribute to chemoresistance in cancer. Hence, the inhibition of ion channels is expected to be a potential target for overcoming chemoresistance effectively.…”

mentioning

confidence: 99%

“…Pro-NFA and GP5 were synthesized respectively following the reported methods (Schemes S1, ESI †), 4 and their chemical structures were confirmed using 1 H NMR, 13 C NMR and HRMS (Fig. S1-S7, ESI †).…”

mentioning

confidence: 99%

Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy

Yang

et al. 2023

Chem. Commun.

Self Cite

View full text Add to dashboard Cite

show abstract

A supramolecular nano-delivery system based on AIE PARP inhibitor prodrug and glycosylated pillar[5]arene for drug-resistance therapy

Abstract: A supramolecular nano-delivery system GP5⊃Pro-ANI based on the host-guest complex of glycosylated pillar[5]arene (GP5) and an amide linked fluorescent PARP inhibitor (4-Amino-1,8-Naphthimide, ANI) was constructed. The PARP inhibitor ANI, capable...

Cited by 10 publications

References 18 publications

Methodologies for Spontaneous Preparation of Chemosensors and Their Arrays Using Off‐the‐Shelf Reagents

Methodologies for Spontaneous Preparation of Chemosensors and Their Arrays Using Off‐the‐Shelf Reagents

Hypoxia-ameliorated photothermal manganese dioxide nanoplatform for reversing doxorubicin resistance

Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy

Contact Info

Product

Resources

About