Preparation and application of chitosan biomaterials in dentistry

Zhang, Chenxi; Hui, Didi; Du, Colin; Sun, Huan; Wei, Peng; Pu, Xiaobing; Li, Zhengyong; Sun, Jing; Zhou, Changchun

doi:10.1016/j.ijbiomac.2020.11.073

Cited by 67 publications

(36 citation statements)

References 86 publications

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“…A more detailed description of the preparation methods applied in the manufacturing of novel chitosan-based delivery systems for dental use is offered by Zhang and co-authors [357].…”

Section: Buccal Treatmentmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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“…A more detailed description of the preparation methods applied in the manufacturing of novel chitosan-based delivery systems for dental use is offered by Zhang and co-authors [357].…”

Section: Buccal Treatmentmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…Providing longer mucosal residence time is essential for treating local inflammatory conditions in the oral cavity when a prolonged therapeutic effect at the site of application is desired. Conventional antimicrobial formulations for the mouth, such as toothpaste and mouthwash, have short duration of action and very low penetration into the periodontal pocket due to the rapid clearance of the administered biomolecules [ 24 ]. An ideal local delivery system should be able to deliver antimicrobial drugs in a controlled manner with good retention at the application site.…”

Section: Natural Polysaccharide Drug Carriers In Dentistrymentioning

confidence: 99%

“…Moreover, most polysaccharides have good adhesion to mucous membranes and enamel surfaces, which is a prerequisite for longer retention at the site of application and prolonged delivery of drugs in the oral cavity [22,23]. There are many examples in the literature reporting the successful use of polysaccharides as micro-and nano drug carriers and outlining their promising application in dentistry [6,9,[24][25][26]. However, the available information so far has not been summarized, which determines the urge for performing a thorough review on that issue.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

et al. 2021

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The intensive development of micro- and nanotechnologies in recent years has offered a wide horizon of new possibilities for drug delivery in dentistry. The use of polymeric drug carriers turned out to be a very successful technique for formulating micro- and nanoparticles with controlled or targeted drug release in the oral cavity. Such innovative strategies have the potential to provide an improved therapeutic approach to prevention and treatment of various oral diseases not only for adults, but also in the pediatric dental practice. Due to their biocompatibility, biotolerance and biodegradability, naturally occurring polysaccharides like chitosan, alginate, pectin, dextran, starch, etc., are among the most preferred materials for preparation of micro- and nano-devices for drug delivery, offering simple particle-forming characteristics and easily tunable properties of the formulated structures. Their low immunogenicity and low toxicity provide an advantage over most synthetic polymers for the development of pediatric formulations. This review is focused on micro- and nanoscale polysaccharide biomaterials as dental drug carriers, with an emphasis on their potential application in pediatric dentistry.

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“…Chitosan loaded with hDPSCs (human dental pulp stem cells) is implanted in rabbit models, and the findings demonstrated the osseointegration and healing of bone in comparison with xenografts in the animal models. Also, chitosan loaded with hDPSCs displayed its potential in the regeneration of bone formation surrounding dental implants and ameliorate osseointegration [44]. Evidence-Based Complementary and Alternative Medicine 8.5.…”

Section: Chitosanmentioning

confidence: 99%

The Role of Biomaterials and Biocompatible Materials in Implant-Supported Dental Prosthesis

Ashtiani

Alam

Tavakolizadeh

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The dental implant is one of the appropriate instances of the different dental materials and their application, which is the combined procedure of technology and science in physics, biomechanics, and surface chemistry from macroscale to nanoscale surface engineering and manufactured technologies. In recent decades, biomaterials in implant therapy promote bone response and biomechanical ability, which is long-term from surgical equipment to final prosthetic restoration. Biomaterials have a crucial role in rehabilitating the damaged structure of the tooth and supplying acceptable outcomes correlated with clinical performance. There are some challenges in implantation such as bleeding, mobility, peri-implant infections, and the solution associated with modern strategies which are regarded to biomaterials. Various materials have been known as promising candidates for coatings of dental implants which contain polyhydroxyalkanoates, calcium phosphate, carbon, bisphosphonates, hydroxyapatite, bone stimulating factors, bioactive glass, bioactive ceramics, collagen, chitosan, metal and their alloys, fluoride, and titanium/titanium nitride. It is pivotal that biomaterials should be biodegradable; for example, polyhydroxyalkanoates are biodegradable; also, they do not have bad effects on tissues and cells. Despite this, biomaterials have important roles in prosthetic conditions such as dental pulp regeneration, the healing process, and antibacterial and anti-inflammatory effects. In this review study, the role of biocompatible materials in dental implants is investigated in in vitro and in vivo studies.

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Preparation and application of chitosan biomaterials in dentistry

Cited by 67 publications

References 86 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

The Role of Biomaterials and Biocompatible Materials in Implant-Supported Dental Prosthesis

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